ENSMUSG00000062248


Mus musculus

Features
Gene ID: ENSMUSG00000062248
  
Biological name :Cks2
  
Synonyms : Cks2 / Cyclin-dependent kinases regulatory subunit 2 / P56390
  
Possible biological names infered from orthology : CDC28 protein kinase regulatory subunit 2 / P33552
  
Species: Mus musculus
  
Chr. number: 13
Strand: 1
Band: A5
Gene start: 51645232
Gene end: 51650660
  
Corresponding Affymetrix probe sets: 10353004 (MoGene1.0st)   10405185 (MoGene1.0st)   10424779 (MoGene1.0st)   1417457_at (Mouse Genome 430 2.0 Array)   1417458_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000075250
NCBI entrez gene - 66197     See in Manteia.
MGI - MGI:1913447
RefSeq - NM_025415
RefSeq Peptide - NP_079691
swissprot - P56390
swissprot - Q545R9
Ensembl - ENSMUSG00000062248
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CKS2ENSDARG00000117089Danio rerio
 CKS2ENSGALG00000038817Gallus gallus
 CKS2ENSG00000123975Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cks1b / P61025 / Cyclin-dependent kinases regulatory subunit 1 ENSMUSG0000002804478
Cks1brt / CDC28 protein kinase 1b, retrogene / CKS1B* / P61024* / CDC28 protein kinase regulatory subunit 1B*ENSMUSG0000006268776


Protein motifs (from Interpro)
Interpro ID Name
 IPR000789  Cyclin-dependent kinase, regulatory subunit
 IPR036858  Cyclin-dependent kinase, regulatory subunit superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IGI
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007127 meiosis I IMP
 biological_processGO:0007346 regulation of mitotic cell cycle IBA
 biological_processGO:0008283 cell proliferation IGI
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0044772 mitotic cell cycle phase transition IGI
 biological_processGO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity IBA
 biological_processGO:0045859 regulation of protein kinase activity IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IBA
 biological_processGO:0051301 cell division IEA
 cellular_componentGO:0000307 cyclin-dependent protein kinase holoenzyme complex IBA
 cellular_componentGO:0019005 SCF ubiquitin ligase complex IBA
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity IEA
 molecular_functionGO:0019901 protein kinase binding IBA
 molecular_functionGO:0042393 histone binding IBA
 molecular_functionGO:0043130 ubiquitin binding IBA
 molecular_functionGO:0061575 cyclin-dependent protein serine/threonine kinase activator activity IBA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Dlx2tm1Jlr/Dlx2tm1Jlr
Genetic Background: involves: 129X1/SvJ

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
Show

Allelic Composition: Dlx2tm1Jlr/Dlx2tm1Jlr
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Cks2TgTn(sb-cHS4,Tyr)2525F-2Ove/Cks2TgTn(sb-cHS4,Tyr)2525F-2Ove
Genetic Background: FVB/N-Cks2TgTn(sb-cHS4,Tyr)2525F-2Ove

 MP:0003205 testicular atrophy "wasting of the male reproductive glands resulting in reduced size" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Dlx2tm1Jlr/Dlx2tm1Jlr
Genetic Background: involves: 129X1/SvJ

 MP:0005159 azoospermia "absence of living spermatozoa " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Dlx2tm1Jlr/Dlx2tm1Jlr
Genetic Background: involves: 129X1/SvJ

 MP:0005168 abnormal female meiosis "malfunction in the process of nuclear division that results in ova with one half the normal chromosome number of the original cell" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Dlx2tm1Jlr/Dlx2tm1Jlr
Genetic Background: involves: 129X1/SvJ

 MP:0008261 arrest of male meiosis "cessation of the progression of the process of nuclear division that results in sperm with one half the normal chromosome number of the original cell" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Dlx2tm1Jlr/Dlx2tm1Jlr
Genetic Background: involves: 129X1/SvJ

 MP:0020550 multinucleated giant male germ cells "presence of large cells containing multiple nuclei formed abnormal opening of the cytoplasmic bridges that are part of normal germ cell division" [PMID:16272280, url:https://ntp.niehs.nih.gov/nnl/male_reproductive/testis/setubmgcel/index.htm]
Show

Allelic Composition: Dlx2tm1Jlr/Dlx2tm1Jlr
Genetic Background: involves: 129X1/SvJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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