ENSMUSG00000033739


Mus musculus

Features
Gene ID: ENSMUSG00000033739
  
Biological name :Fkbpl
  
Synonyms : FK506-binding protein-like / Fkbpl / O35450
  
Possible biological names infered from orthology : Q9UIM3
  
Species: Mus musculus
  
Chr. number: 17
Strand: 1
Band: B1
Gene start: 34644764
Gene end: 34646324
  
Corresponding Affymetrix probe sets: 10444436 (MoGene1.0st)   1422787_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000037273
Ensembl peptide - ENSMUSP00000133960
NCBI entrez gene - 56299     See in Manteia.
MGI - MGI:1932127
RefSeq - XM_006524662
RefSeq - NM_019873
RefSeq - XM_006524661
RefSeq Peptide - NP_063926
swissprot - O35450
swissprot - G3UY63
Ensembl - ENSMUSG00000033739
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fkbplENSDARG00000095322Danio rerio
 FKBPLENSG00000204315Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001440  Tetratricopeptide repeat 1
 IPR011990  Tetratricopeptide-like helical domain superfamily
 IPR013026  Tetratricopeptide repeat-containing domain
 IPR019734  Tetratricopeptide repeat
 IPR023566  Peptidyl-prolyl cis-trans isomerase, FKBP-type


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0045765 regulation of angiogenesis ISO
 biological_processGO:1905553 regulation of blood vessel branching IMP
 cellular_componentGO:0005576 extracellular region IEA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
The role of GTSE1 in G2/M progression after G2 checkpoint


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000249 abnormal blood vessel physiology "anomalous function of any of the tubes that convey blood: arteries, arterioles, capallaries, venules, veins" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: E2f1tm1Njd/E2f1tm1Njd,Klhl40tm1.1Itl/Klhl40tm1.1Itl
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6N

 MP:0003227 abnormal vascular branching morphogenesis "increase, decrease or anomaly in the process by which new vessels sprout off pre-existing vessels" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93157]
Show

Allelic Composition: E2f1tm1Njd/E2f1tm1Njd,Klhl40tm1.1Itl/Klhl40tm1.1Itl
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6N

Allelic Composition: Fkbpltm1.1(KOMP)Wtsi/Fkbpl+
Genetic Background: involves: C57BL/6N * C57BL/6NTac

 MP:0003721 increased tumor growth/size "greater than expected development of tumorous growth when compared to controls" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: E2f1tm1Njd/E2f1tm1Njd,Klhl40tm1.1Itl/Klhl40tm1.1Itl
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6N

Allelic Composition: Fkbpltm1.1(KOMP)Wtsi/Fkbpl+
Genetic Background: involves: C57BL/6N * C57BL/6NTac

 MP:0005601 increased angiogenesis "enhanced process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [RGD:Rat Genome Database submission]
Show

Allelic Composition: E2f1tm1Njd/E2f1tm1Njd,Klhl40tm1.1Itl/Klhl40tm1.1Itl
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6N

Allelic Composition: Fkbpltm1.1(KOMP)Wtsi/Fkbpl+
Genetic Background: involves: C57BL/6N * C57BL/6NTac

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: E2f1tm1Njd/E2f1tm1Njd,Klhl40tm1.1Itl/Klhl40tm1.1Itl
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6N

Allelic Composition: Fkbpltm1.1(KOMP)Wtsi/Fkbpl+
Genetic Background: involves: C57BL/6N * C57BL/6NTac

 MP:0010144 abnormal tumor vascularization "aberrant process of blood vessel formation and the subsequent remodeling process within and/or around tumors" [MGI:mnk "Michelle Knowlton, Mouse Genome Informatics Curator"]
Show

Allelic Composition: E2f1tm1Njd/E2f1tm1Njd,Klhl40tm1.1Itl/Klhl40tm1.1Itl
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6N

Allelic Composition: Fkbpltm1.1(KOMP)Wtsi/Fkbpl+
Genetic Background: involves: C57BL/6N * C57BL/6NTac

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: E2f1tm1Njd/E2f1tm1Njd,Klhl40tm1.1Itl/Klhl40tm1.1Itl
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6N

Allelic Composition: Fkbpltm1.1(KOMP)Wtsi/Fkbpltm1.1(KOMP)Wtsi
Genetic Background: involves: C57BL/6N * C57BL/6NTac

 MP:0012253 abnormal intersomitic vessel morphology "any structural anomaly of the primary blood vessel sprouts that originate from the dorsal aorta and posterior cardinal vein and align dorsoventrally at the myotomal boundaries between somites" [MGI:anna]
Show

Allelic Composition: E2f1tm1Njd/E2f1tm1Njd,Klhl40tm1.1Itl/Klhl40tm1.1Itl
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000023944 P11499 / Hsp90ab1 / Heat shock protein HSP 90-beta / P08238* / heat shock protein 90 alpha family class B member 1*  / reaction / complex
 ENSMUSG00000023067 Cdkn1a / P39689 / Cyclin-dependent kinase inhibitor 1 / P38936* / cyclin dependent kinase inhibitor 1A*  / complex / reaction
 ENSMUSG00000021270 P07901 / Hsp90aa1 / Heat shock protein HSP 90-alpha / P07900* / heat shock protein 90 alpha family class A member 1*  / complex / reaction
 ENSMUSG00000022385 Gtse1 / Q8R080 / G2 and S phase-expressed protein 1 / Q9NYZ3* / G2 and S-phase expressed 1*  / reaction / complex






 

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