ENSMUSG00000037664


Mus musculus

Features
Gene ID: ENSMUSG00000037664
  
Biological name :Cdkn1c
  
Synonyms : Cdkn1c / Mus musculus cyclin-dependent kinase inhibitor 1C (P57) (Cdkn1c), mRNA. / P49919
  
Possible biological names infered from orthology : cyclin dependent kinase inhibitor 1C / P49918
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: F5
Gene start: 143458339
Gene end: 143461050
  
Corresponding Affymetrix probe sets: 10569429 (MoGene1.0st)   1417649_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000147142
Ensembl peptide - ENSMUSP00000037302
Ensembl peptide - ENSMUSP00000128828
Ensembl peptide - ENSMUSP00000147116
NCBI entrez gene - 12577     See in Manteia.
MGI - MGI:104564
RefSeq - XM_006508471
RefSeq - NM_001161624
RefSeq - NM_001354981
RefSeq - NM_009876
RefSeq - XM_006508467
RefSeq - XM_006508468
RefSeq - XM_006508469
RefSeq - XM_006508470
RefSeq Peptide - NP_001155096
RefSeq Peptide - NP_001341910
RefSeq Peptide - NP_034006
swissprot - A0A140LJA8
swissprot - A0A140LJ83
swissprot - P49919
swissprot - Q791X1
Ensembl - ENSMUSG00000037664
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cdkn1caENSDARG00000010878Danio rerio
 cdkn1cbENSDARG00000104903Danio rerio
 CDKN1CENSG00000129757Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cdkn1b / P46414 / Cyclin-dependent kinase inhibitor 1B / P46527*ENSMUSG0000000303112
Cdkn1a / P39689 / Cyclin-dependent kinase inhibitor 1 / P38936* / cyclin dependent kinase inhibitor 1A*ENSMUSG0000002306711


Protein motifs (from Interpro)
Interpro ID Name
 IPR003175  Cyclin-dependent kinase inhibitor
 IPR029842  Cyclin-dependent kinase inhibitor 1C


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IGI
 biological_processGO:0001501 skeletal system development IMP
 biological_processGO:0001822 kidney development IMP
 biological_processGO:0001890 placenta development IMP
 biological_processGO:0006469 negative regulation of protein kinase activity IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007050 cell cycle arrest IEA
 biological_processGO:0007096 regulation of exit from mitosis IGI
 biological_processGO:0007346 regulation of mitotic cell cycle IEA
 biological_processGO:0007568 aging IMP
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0030099 myeloid cell differentiation IGI
 biological_processGO:0030325 adrenal gland development IMP
 biological_processGO:0035264 multicellular organism growth IMP
 biological_processGO:0042326 negative regulation of phosphorylation IDA
 biological_processGO:0042551 neuron maturation IMP
 biological_processGO:0043010 camera-type eye development IMP
 biological_processGO:0055123 digestive system development IMP
 biological_processGO:0060065 uterus development IMP
 biological_processGO:0060669 embryonic placenta morphogenesis IMP
 biological_processGO:0071514 genetic imprinting IMP
 biological_processGO:0071901 negative regulation of protein serine/threonine kinase activity IEA
 biological_processGO:1902746 regulation of lens fiber cell differentiation IGI
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0004860 protein kinase inhibitor activity IEA
 molecular_functionGO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016301 kinase activity IEA


Pathways (from Reactome)
Pathway description
Cyclin D associated events in G1


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000060 delayed bone ossification "late onset of the formation of bone" [J:40203]
Show

Allelic Composition: Cdkn1ctm1Kat/Cdkn1c+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0000111 cleft palate "congenital fissure of the tissues normally uniting to form the palate" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
Show

Allelic Composition: Cdkn1btm1Mlf/Cdkn1btm1Mlf
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

Allelic Composition: Cdkn1ctm1Bbd/Cdkn1c+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Cdkn1atm1Led/Cdkn1atm1Led,Cdkn1ctm1Sje/Cdkn1c+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Cdkn1ctm1Kat/Cdkn1c+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0000131 abnormal long bone epiphysis morphology "the head of a developing long bone that is separated from the shaft by the epiphyseal plate" [J:61509]
Show

Allelic Composition: Cdkn1btm1Mlf/Cdkn1btm1Mlf
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

Allelic Composition: Cdkn1ctm1Sje/Cdkn1ctm1Sje
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Cdkn1atm1Led/Cdkn1atm1Led,Cdkn1ctm1Sje/Cdkn1c+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0000137 abnormal vertebrae morphology "malformed bony segment of the spinal column" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Cdkn1ctm1Kat/Cdkn1c+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0000150 abnormal rib morphology "malformed bones forming the bony wall of the chest" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:50311]
Show

Allelic Composition: Cdkn1atm1Led/Cdkn1atm1Led,Cdkn1ctm1Sje/Cdkn1c+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Cdkn1ctm1Kat/Cdkn1c+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0000153 rib bifurcation "forking or division of ribs, may be a result of partial rib fusions" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Cdkn1atm1Led/Cdkn1atm1Led,Cdkn1ctm1Sje/Cdkn1c+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0000157 abnormal sternum morphology "malformed long flat bone of the chest; articulates with clavicle and first seven rib pairs" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:19212]
Show

Allelic Composition: Cdkn1atm1Led/Cdkn1atm1Led,Cdkn1ctm1Sje/Cdkn1c+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0000462 abnormal digestive system morphology "anomalous structure of the system dedicated to the mechanical, chemical, and enzymatic processing of food" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Cdkn1btm1Mlf/Cdkn1btm1Mlf
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

 MP:0000477 abnormal intestine morphology "malformation of the digestive tube passing from the stomach to the anus" [J:48968]
Show

Allelic Composition: Cdkn1btm1Mlf/Cdkn1btm1Mlf
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

Allelic Composition: Cdkn1ctm1Kat/Cdkn1ctm1Kat
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cdkn1ctm1Bbd/Cdkn1c+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Cdkn1ctm1Kat/Cdkn1c+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cdkn1ctm1Kat/Cdkn1c+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0000498 absent jejunum "missing portion of the small intestine; extends from the duodenum to the ileum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40142]
Show

Allelic Composition: Cdkn1btm1Mlf/Cdkn1btm1Mlf
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

 MP:0000523 cortical glomerulopathies "any disease of the capillary plexus in the kidney cortex" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:63229]
Show

Allelic Composition: Cdkn1ctm1Kat/Cdkn1ctm1Kat
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Cdkn1ctm1Kat/Cdkn1c+
Genetic Background: involves: 129P2/OlaHsd

 MP:0000526 small inner medullary pyramid "reduced size of pyramidal masses; contain part of the secreting tubules and collecting tubules" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203]
Show

Allelic Composition: Cdkn1ctm1Sje/Cdkn1ctm1Sje
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Cdkn1atm1Led/Cdkn1atm1Led,Cdkn1ctm1Sje/Cdkn1c+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0000547 short limbs "reduced average length of the extremities" [MGI:CLS, J:61509]
Show

Allelic Composition: Cdkn1btm1Mlf/Cdkn1btm1Mlf
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

Allelic Composition: Cdkn1ctm1Bbd/Cdkn1c+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000642 enlarged adrenal glands "increased size of the endocrine gland" [J:40203]
Show

Allelic Composition: Gcktm2Mgn/Gcktm2Mgn
Genetic Background: 129S6/SvEvTac-Gcktm2Mgn

Allelic Composition: Cdkn1ctm1.1(Cdkn1b*)Kei/Cdkn1c+
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Cdkn1ctm1Kat/Cdkn1c+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0000757 herniated abdominal wall "protrusions through and/or into the abdominal wall often resulting in the extrusion of viscera" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203]
Show

Allelic Composition: Cdkn1ctm1Kat/Cdkn1ctm1Kat
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cdkn1atm1Led/Cdkn1atm1Led,Cdkn1ctm1Sje/Cdkn1c+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0000759 abnormal skeletal muscle morphology "anomalous structure of any of the striated muscle fibers connected at either or both extremeties with the bony framework of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Cdkn1ctm1Sje/Cdkn1ctm1Sje
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0000761 thin diaphragm muscle "reduced thickness of the diaphragm muscle" [MGI:CLS, J:60159]
Show

Allelic Composition: Cdkn1atm1Led/Cdkn1atm1Led,Cdkn1ctm1Sje/Cdkn1c+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0000897 abnormal midbrain "malformation or malfunction associated with the middle of the three cerebral vesicles of the embryo; this region controls sensory and motor functions, including eye movement and coordination of auditory and visual reflexes" [J:23882, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Cdkn1btm1Mlf/Cdkn1btm1Mlf
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

 MP:0001119 abnormal female reproductive anatomy "anomalous structure of the organs associated with producing offspring in the gender that bears the offspring" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Cdkn1ctm1Kat/Cdkn1ctm1Kat
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001144 fused vaginal opening "condition in which the external vaginal opening is closed by the adherence of the epithelium of the vagina" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cdkn1ctm1Kat/Cdkn1ctm1Kat
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001145 abnormal male reproductive anatomy "anomalous structure of the organs associated with producing offspring in the gender that produces spermatozoa" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Cdkn1ctm1Kat/Cdkn1ctm1Kat
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Cdkn1ctm1Kat/Cdkn1ctm1Kat
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Cdkn1ctm1Bbd/Cdkn1ctm1Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

 MP:0001304 cataracts "complete or partial opacity of the lens" [J:65031]
Show

Allelic Composition: Cdkn1ctm1Kat/Cdkn1c+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001325 abnormal retina morphology "structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cdkn1ctm1Sje/Cdkn1c+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001436 abnormal suckling behavior "reduced ability or inability to exert suction by the mouth, or atypical suckling pattern" [J:16461]
Show

Allelic Composition: Cdkn1btm1Mlf/Cdkn1btm1Mlf
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

Allelic Composition: Cdkn1ctm1Bbd/Cdkn1c+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
Show

Allelic Composition: Cdkn1ctm1Kat/Cdkn1ctm1Kat
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cdkn1ctm1Kat/Cdkn1c+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001711 abnormal placenta 
Show

Allelic Composition: Cdkn1ctm1.1(Cdkn1b*)Kei/Cdkn1c+
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Cdkn1ctm1Kat/Cdkn1c+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001716 abnormal placental labyrinth "malformed structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [J:23171]
Show

Allelic Composition: Cdkn1ctm1Kat/Cdkn1ctm1Kat
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cdkn1ctm1Kat/Cdkn1c+
Genetic Background: involves: 129P2/OlaHsd

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Cdkn1ctm1Kat/Cdkn1c+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001780 decreased brown fat amount "reduced quantity of this thermogenic form of adipose tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Acvr1tm2.1Vlcg/Acvr1+,Gt(ROSA)26Sortm3.1(cre/ERT2)Vlcg/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6NTac

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
Show

Allelic Composition: Cdkn1ctm1Kat/Cdkn1ctm1Kat
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001938 delayed sexual maturation "immaturity of the sexual organs at a given age" [J:61190]
Show

Allelic Composition: Cdkn1ctm1Kat/Cdkn1ctm1Kat
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001954 respiratory distress "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
Show

Allelic Composition: Cdkn1ctm1Kat/Cdkn1ctm1Kat
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cdkn1ctm1Sje/Cdkn1ctm1Sje
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Cdkn1ctm1Kat/Cdkn1c+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cdkn1atm1Led/Cdkn1atm1Led,Cdkn1ctm1Sje/Cdkn1c+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0002082 postnatal lethality "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cdkn1atm1Led/Cdkn1atm1Led,Cdkn1ctm1Sje/Cdkn1c+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0002113 abnormal skeleton development "anomalous differentiation or remodeling of bone tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cdkn1btm1Mlf/Cdkn1btm1Mlf
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

 MP:0002114 abnormal axial skeleton morphology "abnormal development of vertebral, spinal or sternal bones resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cdkn1atm1Led/Cdkn1atm1Led,Cdkn1ctm1Sje/Cdkn1c+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0002115 abnormal skeleton extremities morphology "abnormal development of limb, foot or tail bones resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cdkn1btm1Mlf/Cdkn1btm1Mlf
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

Allelic Composition: Cdkn1atm1Led/Cdkn1atm1Led,Cdkn1ctm1Sje/Cdkn1c+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0002116 abnormal craniofacial bone morphology "abnormal development of cranial or facial bones resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cdkn1btm1Mlf/Cdkn1btm1Mlf
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

 MP:0002135 abnormal kidney morphology "abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Capns1tm2.1Pag/Capns1tm2.1Pag
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0002161 abnormal fertility/fecundity "reduced ability or inability to produce live offspring" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cdkn1ctm1Bbd/Cdkn1ctm1Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

 MP:0002163 abnormal gland morphology "abnormal development of any glandular tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cdkn1ctm1Bbd/Cdkn1ctm1Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cd8atm1.1(cre)Koni/Cd8atm1.1(cre)Koni
Genetic Background: involves: C57BL/6J * C57BL/6NHsd * SJL

 MP:0002264 abnormal bronchus morphology "any structural anomaly of of the upper conducting airways of the lung; these airways arise from the terminus of the trachea " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology , 2nd edition:ISBN 0-397-51047-0, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Cdkn1atm1Led/Cdkn1atm1Led,Cdkn1ctm1Sje/Cdkn1c+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0002267 abnormal bronchiole morphology "any structural anomaly of the conducting airway of the lungs found terminal to the bronchi. These structures contain neither cartilage nor mucous-secreting glands; the epithelium of the bronchioles becomes thinner with each branching. " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology , 2nd edition:ISBN 0-397-51047-0]
Show

Allelic Composition: Cdkn1atm1Led/Cdkn1atm1Led,Cdkn1ctm1Sje/Cdkn1c+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0002270 abnormal alveoli morphology "any structural anomaly of the outpouching of the respiratory system where gas exchange occurs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cdkn1atm1Led/Cdkn1atm1Led,Cdkn1ctm1Sje/Cdkn1c+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0002294 short gestation period "decrease in the average duration of a pregnancy " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cdkn1ctm1Kat/Cdkn1c+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002357 abnormal spleen white pulp morphology "anomalous structure or formation of the splenic area consisting of lymph nodules and diffuse lymphatic tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Cdkn1ctm1Kat/Cdkn1ctm1Kat
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002581 abnormal ileum morphology "malformation of the portion of the small intestine that extends from the jejunum to the colon" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:70183]
Show

Allelic Composition: Cdkn1btm1Mlf/Cdkn1btm1Mlf
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

Allelic Composition: Cdkn1ctm1Sje/Cdkn1ctm1Sje
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Cdkn1atm1Led/Cdkn1atm1Led,Cdkn1ctm1Sje/Cdkn1c+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0002703 abnormal renal tubules "anomalous structure or development of the loops of Henle and collecting ducts in the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cdkn1ctm1Kat/Cdkn1ctm1Kat
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Cdkn1ctm1Kat/Cdkn1c+
Genetic Background: involves: 129P2/OlaHsd

 MP:0002777 absent ovarian follicles "lack of the sac-like structures in the ovaries that surround the ova" [J:42612, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cdkn1ctm1Kat/Cdkn1ctm1Kat
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002842 increased blood pressure "increased tension of the blood within the systemic arteries" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cdkn1ctm1Kat/Cdkn1c+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002962 increased protein excretion "greater than the normal amount of serum proteins voided by the kidneys" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Cdkn1ctm1Kat/Cdkn1c+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cdkn1ctm1Kat/Cdkn1ctm1Kat
Genetic Background: involves: 129P2/OlaHsd

 MP:0002971 abnormal brown fat morphology "defect in the thermogenic form of adipose tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Acvr1tm2.1Vlcg/Acvr1+,Gt(ROSA)26Sortm3.1(cre/ERT2)Vlcg/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6NTac

 MP:0003052 omphalocele "protrusion of abdominal viscera at the base of the umbilical cord, with a covering membranous sac of peritoneum-amnion" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003, ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Cdkn1ctm1Sje/Cdkn1ctm1Sje
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Cdkn1atm1Led/Cdkn1atm1Led,Cdkn1ctm1Sje/Cdkn1c+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Cdkn1ctm1.1(Cdkn1b*)Kei/Cdkn1c+
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Cdkn1ctm1Kat/Cdkn1c+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0003055 abnormal epiphyseal plate morphology "malformed or absent cartilagenous center of ossification on the long bones permitting growth of the bone in both directions during development" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Cdkn1ctm1Kat/Cdkn1c+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0003119 abnormal digestive system development "dysmorphology of the organ system that converts ingested food to nutrients and energy" [smb:Susan M. Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Cdkn1btm1Mlf/Cdkn1btm1Mlf
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

 MP:0003123 paternal imprinting "specific loci are inactivated during spermatogenesis and are not expressed in offspring " [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator, llw2:Linda Washburn, Mouse Genome Informatics Curator]
Show

Allelic Composition: Cdkn1ctm1Bbd/Cdkn1c+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Cdkn1ctm1Kat/Cdkn1c+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cdkn1ctm1Sje/Cdkn1c+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Cdkn1ctm1.1(Cdkn1b*)Kei/Cdkn1c+
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Cdkn1ctm1Kat/Cdkn1c+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0003154 abnormal soft palate "abnormality in the musculomembranous fold that partly separates the mouth and pharynx, located behind the hard palate" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Cdkn1btm1Mlf/Cdkn1btm1Mlf
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

 MP:0003158 dysphagia "difficulty in swallowing food or liquid" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Cdkn1ctm1Kat/Cdkn1ctm1Kat
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cdkn1ctm1Kat/Cdkn1c+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003179 decreased platelet count "fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052]
Show

Allelic Composition: Cdkn1ctm1Kat/Cdkn1c+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cdkn1ctm1Kat/Cdkn1ctm1Kat
Genetic Background: involves: 129P2/OlaHsd

 MP:0003237 abnormal lens epithelium morphology "malformation in the one or more of the layers of epithelial cells in the lens" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93301]
Show

Allelic Composition: Cdkn1ctm1Sje/Cdkn1c+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Cdkn1atm1Led/Cdkn1atm1Led,Cdkn1ctm1Sje/Cdkn1c+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0003257 abnormal abdominal wall "malformation in the margins that enclose the abdominal cavity; the major part is muscular but also includes skin, subcutaneous fat, fascia and the parietal peritoneum" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Cdkn1ctm1.1(Cdkn1b*)Kei/Cdkn1c+
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Cdkn1ctm1Kat/Cdkn1c+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0003271 abnormal duodenum morphology "malformation in the first division of the small intestine that extends from the pyloris to the junction with the jejunum " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Cdkn1btm1Mlf/Cdkn1btm1Mlf
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

 MP:0003419 delayed endochondral bone ossification "late onset of bone formation in bones that form from cartilage" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:94631]
Show

Allelic Composition: Cdkn1btm1Mlf/Cdkn1btm1Mlf
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

 MP:0003568 uterine atresia "congeital absence of the normal opening or lumen of the uterus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Cdkn1ctm1.1(Cdkn1b*)Kei/Cdkn1c+
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Cdkn1ctm1Kat/Cdkn1c+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0003572 abnormal uterus development "abnormal morphogenesis of the female muscular organ of gestation" [ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Cdkn1ctm1Kat/Cdkn1ctm1Kat
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003613 abnormal kidney medulla development 
Show

Allelic Composition: Cdkn1ctm1Sje/Cdkn1ctm1Sje
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Cdkn1atm1Led/Cdkn1atm1Led,Cdkn1ctm1Sje/Cdkn1c+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0003723 abnormal long bone morphology "malformation of any of the several elongated bones of the extremities " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Cdkn1ctm1Sje/Cdkn1ctm1Sje
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0003756 abnormal hard palate "abnormality in the anterior part of the palate that is supported by and includes the palatal extensions of the maxillary and palatine bones " [ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Cdkn1btm1Mlf/Cdkn1btm1Mlf
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

 MP:0003787 abnormal imprinting "defect in the normal inactivation of specific loci during gametogenesis" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cdkn1ctm1Sje/Cdkn1c+
Genetic Background: involves: 129 * C57BL/6

 MP:0003830 abnormal testis development "abnormal morphogenesis of the male reproductive gland containing the germ cells" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:100020]
Show

Allelic Composition: Cdkn1ctm1Kat/Cdkn1ctm1Kat
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cdkn1ctm1Kat/Cdkn1c+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0004002 abnormal jejunum morphology "malformation of the portion of the small intestine that extends from the duodenum to the ileum" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Cdkn1ctm1Sje/Cdkn1ctm1Sje
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Cdkn1atm1Led/Cdkn1atm1Led,Cdkn1ctm1Sje/Cdkn1c+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0004174 abnormal spine curvature "deviation from the typical S-shape of the spine" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Cdkn1atm1Led/Cdkn1atm1Led,Cdkn1ctm1Sje/Cdkn1c+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0004193 abnormal kidney papilla morphology "any structural anomaly of the apex of the renal pyramid that projects into a calyx" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cdkn1ctm1.1(Cdkn1b*)Kei/Cdkn1c+
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Cdkn1ctm1Kat/Cdkn1c+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0004200 reduced fetal size "smaller proportions of a fetus compared to littermates (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cdkn1ctm1Sje/Cdkn1ctm1Sje
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Cdkn1atm1Led/Cdkn1atm1Led,Cdkn1ctm1Sje/Cdkn1c+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0004255 abnormal spongiotrophoblast layer morphology "anomaly in the structure of the outer structural layer of the rodent placenta" [PMID:11433360]
Show

Allelic Composition: Cdkn1ctm1Kat/Cdkn1ctm1Kat
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004260 enlarged placenta "increased size of the size or shape of the organ of metabolic interchange between fetus and mother" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cdkn1ctm1Kat/Cdkn1ctm1Kat
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004320 split sternum "the appearance of an abnormal division in the long flat bone of the chest which articulates with clavicle and first seven rib pairs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cdkn1ctm1Sje/Cdkn1ctm1Sje
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Cdkn1atm1Led/Cdkn1atm1Led,Cdkn1ctm1Sje/Cdkn1c+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0004321 short sternum "reduced length of the long flat bone of the chest which articulates with clavicle and first seven rib pairs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cdkn1atm1Led/Cdkn1atm1Led,Cdkn1ctm1Sje/Cdkn1c+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0004686 decreased length of long bones "reduced end-to-end length of the several elongated bones of the extremities" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cdkn1ctm1Sje/Cdkn1ctm1Sje
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Cdkn1ctm1Kat/Cdkn1c+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0004810 decreased hematopoietic stem cell number "reduced cell count of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd8atm1.1(cre)Koni/Cd8atm1.1(cre)Koni
Genetic Background: involves: C57BL/6J * C57BL/6NHsd * SJL

 MP:0004819 decreased skeletal muscle mass "reduction in the physical bulk, or total amount of matter contained within skeletal muscle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cdkn1atm1Led/Cdkn1atm1Led,Cdkn1ctm1Sje/Cdkn1c+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0004894 uterus atrophy "wasting of the uterus due to injury or disease resulting in reduced size" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cdkn1ctm1.1(Cdkn1b*)Kei/Cdkn1c+
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Cdkn1ctm1Kat/Cdkn1c+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0004920 increased placenta weight "increase in the weight of the organ of metabolic interchange between fetus and mother" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cdkn1ctm1Kat/Cdkn1ctm1Kat
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cdkn1ctm1Kat/Cdkn1c+
Genetic Background: involves: 129P2/OlaHsd

 MP:0005033 abnormal trophoblast cells "anomaly of the cells covering the blastocyst that erode the uterine mucosa and contribute to the formation of the placenta " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator, J:57761]
Show

Allelic Composition: Cdkn1ctm1Kat/Cdkn1ctm1Kat
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cdkn1ctm1Kat/Cdkn1c+
Genetic Background: involves: 129P2/OlaHsd

 MP:0005296 abnormal humerus morphology "malformation of the bone of the forelimb that articulates with the scapula above and the radius and ulna below" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Cdkn1ctm1Kat/Cdkn1ctm1Kat
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005325 abnormal glomerulus "anomalous structure of the capillary loops of the kidney that normally function as a filtration unit" [J:57971, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cdkn1ctm1Kat/Cdkn1c+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cdkn1ctm1Kat/Cdkn1ctm1Kat
Genetic Background: involves: 129P2/OlaHsd

 MP:0005545 abnormal lens development "aberrant formation of the transparent structure of the eye responsible for focusing light rays" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cdkn1atm1Led/Cdkn1atm1Led,Cdkn1ctm1Sje/Cdkn1c+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Cdkn1ctm1Kat/Cdkn1c+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0006144 increased systolic blood pressure "abnormal increase in the pressure in the arteries as the heart contracts and pumps blood into the arteries" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Cdkn1ctm1Kat/Cdkn1ctm1Kat
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Cdkn1ctm1Kat/Cdkn1c+
Genetic Background: involves: 129P2/OlaHsd

 MP:0006320 abnormal interscapular fat pad "any structural anomaly of the encapsulated adipose tissue located between the scapulae" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Acvr1tm2.1Vlcg/Acvr1+,Gt(ROSA)26Sortm3.1(cre/ERT2)Vlcg/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6NTac

 MP:0008148 abnormal rib-sternum attachment "any anomaly in the in the normal joining of the ribs to the sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cdkn1atm1Led/Cdkn1atm1Led,Cdkn1ctm1Sje/Cdkn1c+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0008151 increased diameter of long bones "increased width of the cross-sectional distance that extends from one lateral edge of a long bone, through its center and to the opposite lateral edge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cdkn1ctm1Sje/Cdkn1ctm1Sje
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0008271 abnormal bone ossification "any anomaly in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [GO:0001503]
Show

Allelic Composition: Cdkn1btm1Mlf/Cdkn1btm1Mlf
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

 MP:0008272 abnormal endochondral bone ossification "anomaly in the process of the formation of bone by the replacement of cartilage tissue with mineralized bone" [GO:0001958]
Show

Allelic Composition: Cdkn1ctm1Kat/Cdkn1ctm1Kat
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008273 abnormal intramembranous bone ossification "anomaly in the process of the formation of bone in which osteoblasts secrete a collage-proteoglycan matrix that binds calcium salts and becomes calcified; intramembranous ossification is the way flat bones are formed" [GO:0001957]
Show

Allelic Composition: Cdkn1ctm1Kat/Cdkn1ctm1Kat
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008794 increased lens epithelium apopotosis "increase in the number of lens epithelial cells undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cdkn1ctm1Sje/Cdkn1ctm1Sje
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0009247 meteorism "swelling of the abdomen resulting from gas in the intestinal or peritoneal cavity" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cdkn1btm1Mlf/Cdkn1btm1Mlf
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

Allelic Composition: Cdkn1ctm1Kat/Cdkn1ctm1Kat
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cdkn1ctm1Sje/Cdkn1ctm1Sje
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0009399 increased skeletal muscle fiber size "increase in the size of the large multinucleated cells that make up the skeletal muscles" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cdkn1atm1Led/Cdkn1atm1Led,Cdkn1ctm1Sje/Cdkn1c+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0009546 absent gastric milk in neonates "failure of nursing offspring to ingest milk as indicated by stomach content" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cdkn1btm1Mlf/Cdkn1btm1Mlf
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

Allelic Composition: Cdkn1ctm1Kat/Cdkn1ctm1Kat
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cdkn1ctm1Bbd/Cdkn1c+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009709 hydrometra "an accumulation in the uterine lumen of normal secretions that ordinarily drain from the body but are retained when the cervix or vagina is significantly or completely closed" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cdkn1ctm1Kat/Cdkn1ctm1Kat
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009735 abnormal prostate gland development "anomaly in the formation or pattering of the of the prostate gland" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cdkn1ctm1Kat/Cdkn1ctm1Kat
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009888 palatal shelves fail to meet at midline "polarized growth towards the midline following palatal shelf elevation does not occur" [PMID:16942766]
Show

Allelic Composition: Cdkn1btm1Mlf/Cdkn1btm1Mlf
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

Allelic Composition: Cdkn1ctm1Sje/Cdkn1ctm1Sje
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0009890 cleft secondary palate "congenital fissure of the tissues normally uniting to form the secondary palate" [PMID:16680722]
Show

Allelic Composition: Cdkn1ctm1Kat/Cdkn1ctm1Kat
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cdkn1ctm1Kat/Cdkn1c+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010763 abnormal hematopoietic stem cell physiology "any functional anomaly or number of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; HSCs give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd8atm1.1(cre)Koni/Cd8atm1.1(cre)Koni
Genetic Background: involves: C57BL/6J * C57BL/6NHsd * SJL

Allelic Composition: Cdkn1atm1Led/Cdkn1atm1Led,Cdkn1ctm2.1Kei/Cdkn1c+,Tg(Mx1-cre)1Cgn/0
Genetic Background: B6.Cg-Cdkn1ctm2.1Kei Cdkn1atm1Led Tg(Mx1-cre)1Cgn

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Cdkn1ctm1Sje/Cdkn1ctm1Sje
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Cdkn1ctm1Sje/Cdkn1c+
Genetic Background: involves: 129 * C57BL/6

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Cdkn1ctm1Kat/Cdkn1ctm1Kat
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cdkn1ctm1Sje/Cdkn1c+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Acvr1tm2.1Vlcg/Acvr1+,Gt(ROSA)26Sortm3.1(cre/ERT2)Vlcg/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6NTac

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Cdkn1btm1Mlf/Cdkn1btm1Mlf
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

Allelic Composition: Cdkn1ctm1Bbd/Cdkn1ctm1Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

Allelic Composition: Cdkn1ctm1Kat/Cdkn1ctm1Kat
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cdkn1ctm1Bbd/Cdkn1c+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Cdkn1ctm1Kat/Cdkn1c+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cdkn1ctm1Kat/Cdkn1c+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
Show

Allelic Composition: Cdkn1atm1Led/Cdkn1atm1Led,Cdkn1ctm1Sje/Cdkn1c+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Cdkn1atm1.1(KOMP)Vlcg/Cdkn1atm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Cdkn1atm1.1(KOMP)Vlcg/Ucd

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Cdkn1btm1Mlf/Cdkn1btm1Mlf
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

Allelic Composition: Cdkn1ctm1Bbd/Cdkn1ctm1Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

Allelic Composition: Cdkn1ctm1Kat/Cdkn1ctm1Kat
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cdkn1ctm1Sje/Cdkn1ctm1Sje
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Cdkn1ctm1Bbd/Cdkn1c+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Cdkn1ctm1Kat/Cdkn1c+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cdkn1ctm1Sje/Cdkn1c+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Cdkn1atm1Led/Cdkn1atm1Led,Cdkn1ctm1Sje/Cdkn1c+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0011304 kidney papillary atrophy "acquired diminution of the size of the apex (tip) of a renal pyramid associated with wasting as from death and reabsorbtion of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes" [MGI:anna]
Show

Allelic Composition: Cd8atm1.1(cre)Koni/Cd8atm1.1(cre)Koni
Genetic Background: involves: C57BL/6J * C57BL/6NHsd * SJL

 MP:0011697 vacuolated lens "fluid filled cavities are present in the cytoplasm of the transparent structure of the eye responsible for focusing light" [MGI:llw2]
Show

Allelic Composition: Cdkn1ctm1Sje/Cdkn1ctm1Sje
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0012503 increased midbrain apoptosis "increase in the number of cells of the midbrain undergoing programmed cell death" [MGI:anna]
Show

Allelic Composition: Cdkn1btm1Mlf/Cdkn1btm1Mlf
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

 MP:0013317 abnormal seminal vesicle development "aberrant or incomplete differentiation of either of the paired sac-like glandular structures situated posterolateral to the urinary bladder in the male and functioning as part of the reproductive system; seminal vesicles develop from the segments of the Wolffian ducts immediately adjacent to the urogenital sinus" [MGI:Anna]
Show

Allelic Composition: Cdkn1ctm1Kat/Cdkn1ctm1Kat
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr