ENSMUSG00000073802


Mus musculus

Features
Gene ID: ENSMUSG00000073802
  
Biological name :Cdkn2b
  
Synonyms : Cdkn2b / Cyclin-dependent kinase 4 inhibitor B / P55271
  
Possible biological names infered from orthology : cyclin dependent kinase inhibitor 2B / P42772
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: C4
Gene start: 89306289
Gene end: 89311032
  
Corresponding Affymetrix probe sets: 10514347 (MoGene1.0st)   1449152_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000095595
NCBI entrez gene - 12579     See in Manteia.
MGI - MGI:104737
RefSeq - NM_007670
RefSeq Peptide - NP_031696
swissprot - P55271
swissprot - Q549R4
Ensembl - ENSMUSG00000073802
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cdkn2a/bENSDARG00000037262Danio rerio
 CDKN2BENSGALG00000026137Gallus gallus
 CDKN2BENSG00000147883Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cdkn2d / Q60773 / Cyclin-dependent kinase 4 inhibitor D / P55273* / cyclin dependent kinase inhibitor 2D*ENSMUSG0000009647248
Cdkn2c / Q60772 / Cyclin-dependent kinase 4 inhibitor C / P42773* / cyclin dependent kinase inhibitor 2C*ENSMUSG0000002855140


Protein motifs (from Interpro)
Interpro ID Name
 IPR002110  Ankyrin repeat
 IPR020683  Ankyrin repeat-containing domain
 IPR036770  Ankyrin repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity IEA
 biological_processGO:0000086 G2/M transition of mitotic cell cycle IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007050 cell cycle arrest IEA
 biological_processGO:0007093 mitotic cell cycle checkpoint IEA
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0030219 megakaryocyte differentiation IEA
 biological_processGO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway IEA
 biological_processGO:0031668 cellular response to extracellular stimulus IEA
 biological_processGO:0031670 cellular response to nutrient IEA
 biological_processGO:0042326 negative regulation of phosphorylation IEA
 biological_processGO:0048536 spleen development IGI
 biological_processGO:0050680 negative regulation of epithelial cell proliferation IEA
 biological_processGO:0071901 negative regulation of protein serine/threonine kinase activity IEA
 biological_processGO:2000134 negative regulation of G1/S transition of mitotic cell cycle IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0019901 protein kinase binding IEA


Pathways (from Reactome)
Pathway description
Oxidative Stress Induced Senescence
Senescence-Associated Secretory Phenotype (SASP)
Oncogene Induced Senescence
Cyclin D associated events in G1


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000220 increased monocyte count "greater than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Trip13Gt(CH0621)Wtsi/Trip13Gt(CH0621)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000240 extramedullary hematopoiesis "formation and development of blood cells outside the bone marrow, e.g., in the spleen, liver, or lymph nodes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Cdkn2atm1Rdp/Cdkn2atm1Rdp
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

Allelic Composition: Cdkn2btm1Bbd/Cdkn2btm1Bbd,Cdkn2ctm1Bbd/Cdkn2ctm1Bbd
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0000627 abnormal mammary gland morphology "malformation of the milk-secreting gland that lies within the breast; usually rudimentary in males" [J:70183]
Show

Allelic Composition: Cdk5r1tm1Lht/Cdk5r1tm1Lht,Cdk5r2tm1Lht/Cdk5r2tm1Lht
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000688 lymphoid hyperplasia "increased cell number in lymphatic tissues" [J:62478]
Show

Allelic Composition: Cdkn2atm1Rdp/Cdkn2atm1Rdp
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

Allelic Composition: Cdkn2btm1Bbd/Cdkn2btm1Bbd,Cdkn2ctm1Bbd/Cdkn2ctm1Bbd
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0000689 abnormal spleen morphology "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]
Show

Allelic Composition: Cdkn2atm1Rdp/Cdkn2atm1Rdp
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

Allelic Composition: Cdkn2btm1Bbd/Cdkn2btm1Bbd,Pbx1tm1Koss/Pbx1tm1Koss,Nkx2-5tm2(cre)Rph/Nkx2-5+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cdkn2btm1Bbd/Cdkn2btm1Bbd,Cdkn2ctm1Bbd/Cdkn2ctm1Bbd
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0000693 spleen hyperplasia "increased cell number in the spleen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33401]
Show

Allelic Composition: Cdkn2atm1Rdp/Cdkn2atm1Rdp
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

 MP:0001146 abnormal testis morphology "anomalous structure of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Cdk5r1tm1Lht/Cdk5r1tm1Lht,Cdk5r2tm1Lht/Cdk5r2tm1Lht
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001148 enlarged testes "increased size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:63229]
Show

Allelic Composition: Cdkn2btm1Bbd/Cdkn2btm1Bbd,Cdkn2ctm1Bbd/Cdkn2ctm1Bbd
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001154 seminiferous tubule degeneration "a retrogressive impairment of function or destruction of the tubules in the testes where spermatogenesis occurs" [J:50844]
Show

Allelic Composition: Cdkn2btm1Bbd/Cdkn2btm1Bbd,Cdkn2ctm1Bbd/Cdkn2ctm1Bbd
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002020 increased tumor incidence "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]
Show

Allelic Composition: Cdkn2atm1Rdp/Cdkn2atm1Rdp
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

Allelic Composition: Cdkn2btm1Bbd/Cdkn2btm1Bbd,Cdkn2ctm1Bbd/Cdkn2ctm1Bbd
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002032 sarcoma "connective tissue neoplasm associated with the proliferation of mesodermal cells" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:58877]
Show

Allelic Composition: Cdkn2atm1Rdp/Cdkn2atm1Rdp
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

Allelic Composition: Cdkn2btm1Bbd/Cdkn2btm1Bbd,Cdkn2ctm1Bbd/Cdkn2ctm1Bbd
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002041 pituitary adenoma "appearance of benign neoplasms of the pituitary" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33042]
Show

Allelic Composition: Cdkn2btm1Bbd/Cdkn2btm1Bbd,Cdkn2ctm1Bbd/Cdkn2ctm1Bbd
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cdkn2atm1Rdp/Cdkn2atm1Rdp
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

 MP:0002346 abnormal lymph node secondary follicle "anomaly in the immunologically active area of the lymph node cortex " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology:ISBN 0-397-51047-0]
Show

Allelic Composition: Cdkn2atm1Rdp/Cdkn2atm1Rdp
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

 MP:0002362 abnormal spleen marginal zone morphology "anomalous structure of the area surrounding the marginal sinus and containing lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Cdkn2atm1Rdp/Cdkn2atm1Rdp
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

 MP:0002413 abnormal megakaryoblast morphology/development "anomalous structure or development of the progenitor cells of the thrombocytic (platelet) line of cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Trip13Gt(CH0621)Wtsi/Trip13Gt(CH0621)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002619 abnormal lymphocyte morphology/development "anomalous structure, differentiation, or number of the white blood cells formed in the body s lymphoid tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Cdkn2atm1Rdp/Cdkn2atm1Rdp
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

Allelic Composition: Cdkn2btm1Bbd/Cdkn2btm1Bbd,Cdkn2ctm1Bbd/Cdkn2ctm1Bbd
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0003336 pancreatic cysts "the appearance of fluid-filled sacs within the pancreas" [ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Cdkn2btm1Bbd/Cdkn2btm1Bbd,Cdkn2ctm1Bbd/Cdkn2ctm1Bbd
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0003675 kidney cysts "abnormal membranous sacs in any portion of the pair of organs responsible for urine secretion" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Cdkn2btm1Bbd/Cdkn2btm1Bbd,Cdkn2ctm1Bbd/Cdkn2ctm1Bbd
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0004499 increased incidence of chemically-induced tumors "higher than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cdkn2atm1.1Brn/Cdkn2atm1.1Brn,Cdkn2btm2Brn/Cdkn2btm2Brn
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cdkn2atm1Rdp/Cdkn2atm1Rdp
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

Allelic Composition: Cdkn2btm1Bbd/Cdkn2btm1Bbd,Cdkn2ctm1Bbd/Cdkn2ctm1Bbd
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0006262 testis tumor "presence of abnormal rapidly proliferating cells in the testis, usually in the form of a distinct mass" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:60034]
Show

Allelic Composition: Cdkn2btm1Bbd/Cdkn2btm1Bbd,Cdkn2ctm1Bbd/Cdkn2ctm1Bbd
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0006410 abnormal common myeloid progenitor cell morphology "anomaly in the structure of the hematopoietic stem cells that are capable of forming any of the myeloid lineage cells (erythrocytes, granulocytes, thrombocytes, monocytes, and mast cells) but not cells of the lymphoid lineage" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Trip13Gt(CH0621)Wtsi/Trip13Gt(CH0621)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0006423 dilated rete testis "an expansion in the volume or area of the network of canals located at the termination of the straight tubules in the mediastinum testis, usually with an increase in contained fluid" [J:121125, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cdkn2btm1Bbd/Cdkn2btm1Bbd,Cdkn2ctm1Bbd/Cdkn2ctm1Bbd
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0008102 lymph node hyperplasia "overdevelopment or increased size, usually due to increased cell number, in the lymph nodes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cdkn2atm1Rdp/Cdkn2atm1Rdp
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

Allelic Composition: Cdkn2btm1Bbd/Cdkn2btm1Bbd,Cdkn2ctm1Bbd/Cdkn2ctm1Bbd
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0008117 abnormal Langerhans cell morphology "any structural anomaly of a stellate dendritic cell of myeloid origin, that appears clear on light microscopy and has a dark-staining, indented nucleus and characteristic inclusions (Birbeck granules) in the cytoplasm; Langerhans cells are found principally in the stratum spinosum of the epidermis, but they also occur in other stratified epithelia and have been identified in the lung, lymph nodes, spleen, and thymus" [CL:0000453, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cdkn2btm1Bbd/Cdkn2btm1Bbd,Cdkn2ctm1Bbd/Cdkn2ctm1Bbd
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0008210 increased mature B cell number "greater number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149]
Show

Allelic Composition: Cdkn2atm1Rdp/Cdkn2atm1Rdp
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

 MP:0008522 abnormal lymph node germinal center "any strucutral anomaly of the area of the lymph node secondary follicle where B cells are stimulated by antigens and helper T cells are stimulated to generate memory cells" [MESH:A10.549.400.500, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cdkn2atm1Rdp/Cdkn2atm1Rdp
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

 MP:0008973 decreased erythroid progenitor cell number "reduced numbers of progenitors of the erythrocyte lineage" [CL:0000038, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Trip13Gt(CH0621)Wtsi/Trip13Gt(CH0621)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009308 adenocarcinoma "malignant neoplasm of epithelial cells in a glandular or glandular-like pattern" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Cdkn2atm1Rdp/Cdkn2atm1Rdp
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

 MP:0010300 increased skin tumor incidence "greater than the expected number of neoplasms in the skin tissue usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cdkn2atm1.1Brn/Cdkn2atm1.1Brn,Cdkn2btm2Brn/Cdkn2btm2Brn
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0010373 myeloid hyperplasia "greater than normal number of nucleated cells of the myeloid lineage (a monocyte, granulocyte, or mast cell), found in blood or other tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Trip13Gt(CH0621)Wtsi/Trip13Gt(CH0621)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011263 abnormal spleen mesenchyme morphology "any structural anomaly of the embryonic connective tissue made up of loosely aggregated mesenchymal cells, supported by interlaminar jelly, that gives rise to the developing spleen" [ISBN:0-683-40008-8, MGI:csmith]
Show

Allelic Composition: Cdkn2btm1Bbd/Cdkn2btm1Bbd,Pbx1tm1Koss/Pbx1tm1Koss,Nkx2-5tm2(cre)Rph/Nkx2-5+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv

 MP:0011703 increased fibroblast proliferation "greater the expansion rate of a fibroblast cell population by cell division" [MGI:csmith]
Show

Allelic Composition: Cdkn2atm1Rdp/Cdkn2atm1Rdp
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

Allelic Composition: Cdkn2btm1Bbd/Cdkn2btm1Bbd,Cdkn2ctm1Bbd/Cdkn2ctm1Bbd
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0012431 increased lymphoma incidence "greater than the expected number of neoplasms characterized by a proliferation of malignant lymphocytes in lymphoid tissue in a specific population in a given time period" [http://orcid.org/0000-0001-5208-3432, MGI:csmith]
Show

Allelic Composition: Cdkn2btm1Bbd/Cdkn2btm1Bbd,Cdkn2ctm1Bbd/Cdkn2ctm1Bbd
Genetic Background: involves: 129S1/Sv * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000006728 Cdk4 / P30285 / Cyclin-dependent kinase 4 / P11802*  / reaction / complex
 ENSMUSG00000040274 Cdk6 / Q64261 / Cyclin-dependent kinase 6 / Q00534*  / reaction / complex






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr