ENSMUSG00000029062


Mus musculus

Features
Gene ID: ENSMUSG00000029062
  
Biological name :Cdk11b
  
Synonyms : Cdk11b / Mus musculus cyclin-dependent kinase 11B (Cdk11b), transcript variant 3, mRNA. / P24788
  
Possible biological names infered from orthology : CDK11A / cyclin dependent kinase 11A / cyclin dependent kinase 11B / Q9UQ88
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: E2
Gene start: 155624854
Gene end: 155649938
  
Corresponding Affymetrix probe sets: 10511113 (MoGene1.0st)   1418841_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000070527
Ensembl peptide - ENSMUSP00000101223
Ensembl peptide - ENSMUSP00000101225
NCBI entrez gene - 12537     See in Manteia.
MGI - MGI:88353
RefSeq - XM_017319934
RefSeq - NM_001347308
RefSeq - NM_001355567
RefSeq - NM_001355568
RefSeq - NM_007661
RefSeq - XM_011250179
RefSeq - XM_017319929
RefSeq - XM_017319930
RefSeq - XM_017319931
RefSeq - XM_017319932
RefSeq - XM_017319933
RefSeq - XM_006538508
RefSeq - XM_006538510
RefSeq - XM_006538511
RefSeq - XM_006538512
RefSeq Peptide - NP_001334237
RefSeq Peptide - NP_001342496
RefSeq Peptide - NP_001342497
RefSeq Peptide - NP_031687
swissprot - P24788
swissprot - A2A9P6
Ensembl - ENSMUSG00000029062
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cdk11bENSDARG00000102546Danio rerio
 CDK11AENSGALG00000001382Gallus gallus
 CDK11AENSG00000008128Homo sapiens
 CDK11BENSG00000248333Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cdk10 / Q3UMM4 / Cyclin-dependent kinase 10 / Q15131*ENSMUSG0000003386224
Cdk3-ps / cyclin dependent kinase 3 / CDK3* / Q00526*ENSMUSG0000009230018
Cdk2 / P97377 / Cyclin-dependent kinase 2 / P24941*ENSMUSG0000002535817
Cdk5 / P49615 / Cyclin-dependent-like kinase 5 / Q00535* / cyclin dependent kinase 5*ENSMUSG0000002896916
Cdk6 / Q64261 / Cyclin-dependent kinase 6 / Q00534*ENSMUSG0000004027416
Cdk1 / P11440 / Cyclin-dependent kinase 1 / P06493*ENSMUSG0000001994216
Cdk4 / P30285 / Cyclin-dependent kinase 4 / P11802*ENSMUSG0000000672815
E030030I06RikENSMUSG000000973276


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001824 blastocyst development IMP
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007088 regulation of mitotic nuclear division IMP
 biological_processGO:0010468 regulation of gene expression IBA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0050684 regulation of mRNA processing ISO
 biological_processGO:2001234 negative regulation of apoptotic signaling pathway IMP
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm TAS
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity ISO
 molecular_functionGO:0004693 cyclin-dependent protein serine/threonine kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Kcna1mceph/Kcna1mceph
Genetic Background: BALB/cByJ-Kcna1mceph/J

 MP:0001219 thickened epidermis "increase in the width of the epidermal cell layer in the skin" [J:65146]
Show

Allelic Composition: Matn3tm1Mbri/Matn3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
Show

Allelic Composition: Kcna1mceph/Kcna1mceph
Genetic Background: BALB/cByJ-Kcna1mceph/J

 MP:0002051 skin papilloma "a circumscribed, benign epithelial tumor projecting from the surrounding surface" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Matn3tm1Mbri/Matn3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002060 abnormal skin morphology "malformation or atypical structure of the membranous protective covering of the body" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:56777]
Show

Allelic Composition: Matn3tm1Mbri/Matn3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003694 failure to hatch from the zona pellucida "the embryo fails to break out of the thick solid transparent outer membrane that surrounds the developing ovum and embryo prior to implantation, may be seen in vivo or in cultured embryos" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Kcna1mceph/Kcna1mceph
Genetic Background: BALB/cByJ-Kcna1mceph/J

 MP:0011094 complete embryonic lethality before implantation "death of all organisms of a given genotype in a population between fertilization and implantation (Mus: E0 to less than E4.5)" [MGI:csmith]
Show

Allelic Composition: Kcna1mceph/Kcna1mceph
Genetic Background: BALB/cByJ-Kcna1mceph/J

 MP:0013504 increased embryonic tissue cell apoptosis "increase in the timing or the number of cells in embryonic tissue undergoing programmed cell death" [MGI:csmith]
Show

Allelic Composition: Kcna1mceph/Kcna1mceph
Genetic Background: BALB/cByJ-Kcna1mceph/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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