ENSG00000129355


Homo sapiens

Features
Gene ID: ENSG00000129355
  
Biological name :CDKN2D
  
Synonyms : CDKN2D / cyclin dependent kinase inhibitor 2D / P55273
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: -1
Band: p13.2
Gene start: 10566462
Gene end: 10569059
  
Corresponding Affymetrix probe sets: 210240_s_at (Human Genome U133 Plus 2.0 Array)   213586_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000377224
Ensembl peptide - ENSP00000337056
NCBI entrez gene - 1032     See in Manteia.
OMIM - 600927
RefSeq - NM_001800
RefSeq - NM_079421
RefSeq Peptide - NP_001791
RefSeq Peptide - NP_524145
swissprot - P55273
swissprot - A0A024R796
Ensembl - ENSG00000129355
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cdkn2dENSDARG00000094176Danio rerio
 Cdkn2dENSMUSG00000096472Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CDKN2C / P42773 / cyclin dependent kinase inhibitor 2CENSG0000012308042
CDKN2A / P42771 / Q8N726 / cyclin dependent kinase inhibitor 2AENSG0000014788939
CDKN2B / P42772 / cyclin dependent kinase inhibitor 2BENSG0000014788336


Protein motifs (from Interpro)
Interpro ID Name
 IPR002110  Ankyrin repeat
 IPR020683  Ankyrin repeat-containing domain
 IPR036770  Ankyrin repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity IDA
 biological_processGO:0000082 G1/S transition of mitotic cell cycle IDA
 biological_processGO:0000731 DNA synthesis involved in DNA repair IMP
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007050 cell cycle arrest IDA
 biological_processGO:0007605 sensory perception of sound IEA
 biological_processGO:0008285 negative regulation of cell proliferation IDA
 biological_processGO:0009411 response to UV IMP
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0030308 negative regulation of cell growth IDA
 biological_processGO:0031658 negative regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle TAS
 biological_processGO:0032526 response to retinoic acid IMP
 biological_processGO:0033280 response to vitamin D IMP
 biological_processGO:0042326 negative regulation of phosphorylation IDA
 biological_processGO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IMP
 biological_processGO:0048102 autophagic cell death IMP
 biological_processGO:1902230 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage IMP
 biological_processGO:1902807 negative regulation of cell cycle G1/S phase transition IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0097129 cyclin D2-CDK4 complex IEA
 molecular_functionGO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0019901 protein kinase binding IPI


Pathways (from Reactome)
Pathway description
Oxidative Stress Induced Senescence
Senescence-Associated Secretory Phenotype (SASP)
Oncogene Induced Senescence
Cyclin D associated events in G1


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0000488 Retinopathy 
Show

 HP:0000958 Dry skin 
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 HP:0001480 Freckling 
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 HP:0001595 Hair abnormality 
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 HP:0002071 Extrapyramidal signs 
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 HP:0002861 Malignant melanoma "A malignant skin tumor of originating from melanocytes, pigment cells normally present in the epidermis and sometimes in the dermis." [HPO:curators]
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 HP:0002894 Pancreatic cancer 
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 HP:0003764 Abnormal or excess nevi 
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 HP:0006753 Increased gastric cancer 
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 HP:0100013 Neoplasia of the breast 
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 HP:0100763 Abnormality of the lymphatic system 
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000105810 CDK6 / Q00534 / cyclin dependent kinase 6  / reaction / complex
 ENSG00000135446 CDK4 / P11802 / cyclin dependent kinase 4  / reaction / complex






 

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