ENSMUSG00000021010


Mus musculus

Features
Gene ID: ENSMUSG00000021010
  
Biological name :Npas3
  
Synonyms : neuronal PAS domain protein 3 / Npas3
  
Possible biological names infered from orthology : Q8IXF0
  
Species: Mus musculus
  
Chr. number: 12
Strand: 1
Band: C1
Gene start: 53248677
Gene end: 54072175
  
Corresponding Affymetrix probe sets: 10395719 (MoGene1.0st)   10395733 (MoGene1.0st)   1421567_at (Mouse Genome 430 2.0 Array)   1429138_at (Mouse Genome 430 2.0 Array)   1438060_at (Mouse Genome 430 2.0 Array)   1450287_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000152696
Ensembl peptide - ENSMUSP00000098975
Ensembl peptide - ENSMUSP00000152411
Ensembl peptide - ENSMUSP00000152452
NCBI entrez gene - 27386     See in Manteia.
MGI - MGI:1351610
RefSeq - XM_006515943
RefSeq - XM_006515938
RefSeq - XM_006515939
RefSeq - XM_006515940
RefSeq - XM_006515941
RefSeq - XM_006515942
RefSeq - NM_013780
RefSeq Peptide - NP_038808
swissprot - F8VQB2
swissprot - A0A1Y7VM06
swissprot - A0A1Y7VJG5
swissprot - U5KBZ7
Ensembl - ENSMUSG00000021010
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 NPAS3ENSDARG00000109820Danio rerio
 NPAS3ENSGALG00000029022Gallus gallus
 NPAS3ENSG00000151322Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Npas1 / P97459 / Neuronal PAS domain-containing protein 1 / Q99742* / neuronal PAS domain protein 1*ENSMUSG0000000198832
Sim1 / Q61045 / Single-minded homolog 1 / P81133* / single-minded family bHLH transcription factor 1*ENSMUSG0000001991324
Sim2 / Q61079 / Single-minded homolog 2 / Q14190* / single-minded family bHLH transcription factor 2*ENSMUSG0000006271323
Epas1 / P97481 / Endothelial PAS domain-containing protein 1 / Q99814* / endothelial PAS domain protein 1*ENSMUSG0000002414020
Hif1a / Q61221 / Hypoxia-inducible factor 1-alpha / Q16665* / hypoxia inducible factor 1 alpha subunit*ENSMUSG0000002110920
Hif3a / Q0VBL6 / Hypoxia-inducible factor 3-alpha / Q9Y2N7* / hypoxia inducible factor 3 alpha subunit*ENSMUSG0000000432818
Arnt2 / Q61324 / Aryl hydrocarbon receptor nuclear translocator 2 / Q9HBZ2*ENSMUSG0000001570913
Arnt / P53762 / Aryl hydrocarbon receptor nuclear translocator / P27540*ENSMUSG0000001552213
Arntl2 / Q2VPD4 / Aryl hydrocarbon receptor nuclear translocator-like protein 2 / Q8WYA1* / aryl hydrocarbon receptor nuclear translocator like 2*ENSMUSG0000004018711
Arntl / Q9WTL8 / Mus musculus aryl hydrocarbon receptor nuclear translocator-like (Arntl), transcript variant 3, mRNA. / O00327* / aryl hydrocarbon receptor nuclear translocator like*ENSMUSG0000005511611
Clock / O08785 / Circadian locomoter output cycles protein kaput / O15516* / clock circadian regulator*ENSMUSG0000002923811
Npas2 / neuronal PAS domain protein 2 / Q99743*ENSMUSG0000002607710


Protein motifs (from Interpro)
Interpro ID Name
 IPR000014  PAS domain
 IPR011598  Myc-type, basic helix-loop-helix (bHLH) domain
 IPR013655  PAS fold-3
 IPR013767  PAS fold
 IPR035965  PAS domain superfamily
 IPR036638  Helix-loop-helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0046983 protein dimerization activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000780 abnormal corpus callosum morphology "malformation or absence of a thick bundle of nerve fibers comprising a commissural plate connecting the two cerebral hemispheres; it consists of contralateral axon projections that provides communications between the right and left cerebral hemispheres" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Npas3tm1Ewb/Npas3tm1Ewb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000807 abnormal hippocampus morphology "absent or malformed deep lying structure of the cerebrum involved with memory storage and spatial navigation" [The Atlas of Mouse Development:ISBN 0-12-402035-6, MGI:Cls, J:38857]
Show

Allelic Composition: Npas3tm1Ewb/Npas3tm1Ewb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000857 abnormal cerebellar foliation "malformation of small offshoots of the cerebellar lobules" [Principles of Neural Science:ISBN 0-8385-8034-3, J:52951]
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Allelic Composition: Npas3tm1Ewb/Npas3tm1Ewb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001183 overexpanded alveoli "expanded volume of the saclike terminal dilation of the respiratory bronchioles" [J:66345]
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Allelic Composition: Fcamrtm2Shib/Fcamrtm2Shib
Genetic Background: BALB/c-Fcamrtm2Shib

Allelic Composition: Npas3tm1Mesu/Npas3+
Genetic Background: B6.129S6-Npas3tm1Mesu

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Fgf8tm1.3Mrt/Fgf8tm1.4Mrt,Tg(T-cre)1Lwd/0
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6 * CD-1

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Pitx2tm3.1Jfm/Pitx2tm3.1Jfm
Genetic Background: involves: 129S4/SvJaeSor

Allelic Composition: Npas1tm1Slm/Npas1tm1Slm,Npas3tm1Slm/Npas3tm1Slm
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0001360 abnormal social investigation "altered behavior of animals to approach and examine other animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pitx2tm3.1Jfm/Pitx2tm3.1Jfm
Genetic Background: involves: 129S4/SvJaeSor

Allelic Composition: Npas1tm1Slm/Npas1tm1Slm,Npas3tm1Slm/Npas3tm1Slm
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0001364 decreased anxiety-related response "when compared to controls, subjects exhibit fewer responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:86626, J:85438, J:64043]
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Allelic Composition: Fgf8tm1.3Mrt/Fgf8tm1.4Mrt,Tg(T-cre)1Lwd/0
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6 * CD-1

 MP:0001386 abnormal maternal nurturing "failure of mothers to tend offspring" [J:39801]
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Allelic Composition: Pitx2tm3.1Jfm/Pitx2tm3.1Jfm
Genetic Background: involves: 129S4/SvJaeSor

Allelic Composition: Npas1tm1Slm/Npas1tm1Slm,Npas3tm1Slm/Npas3tm1Slm
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
Show

Allelic Composition: Pitx2tm3.1Jfm/Pitx2tm3.1Jfm
Genetic Background: involves: 129S4/SvJaeSor

Allelic Composition: Npas1tm1Slm/Npas1tm1Slm,Npas3tm1Slm/Npas3tm1Slm
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Fgf8tm1.3Mrt/Fgf8tm1.4Mrt,Tg(T-cre)1Lwd/0
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6 * CD-1

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
Show

Allelic Composition: Fgf8tm1.3Mrt/Fgf8tm1.4Mrt,Tg(T-cre)1Lwd/0
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6 * CD-1

 MP:0001407 short stride length "reduced average distance between steps" [J:34193]
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Allelic Composition: Pitx2tm3.1Jfm/Pitx2tm3.1Jfm
Genetic Background: involves: 129S4/SvJaeSor

Allelic Composition: Npas1tm1Slm/Npas1tm1Slm,Npas3tm1Slm/Npas3tm1Slm
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Npas3tm1Ewb/Npas3tm1Ewb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001408 stereotypic behavior "repetitive, invariant, perseverative motor patterns that do not appear to be purposeful" [What s wrong with my mouse?:ISBN 0-471-31639-3]
Show

Allelic Composition: Pitx2tm3.1Jfm/Pitx2tm3.1Jfm
Genetic Background: involves: 129S4/SvJaeSor

Allelic Composition: Npas1tm1Slm/Npas1tm1Slm,Npas3tm1Slm/Npas3tm1Slm
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Npas1tm1Slm/Npas1+,Npas3tm1Slm/Npas3tm1Slm
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0001415 increased exploration in new environment "greater amount of time spent investigating new location" [J:28825]
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Allelic Composition: Npas3tm1Ewb/Npas3tm1Ewb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001447 abnormal nest building behavior "deviation from the usual behavior of mice to build sleeping nests out of any available materials; also of female mice to bulid nests to protect offspring" [J:42758, What s wrong with my mouse?:ISBN 0-471-31639-3]
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Allelic Composition: Fgf8tm1.3Mrt/Fgf8tm1.4Mrt,Tg(T-cre)1Lwd/0
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6 * CD-1

 MP:0001454 abnormal cued conditioning behavior "defect in the ability of an animal to learn and remember an association between an an aversive experience (the unconditioned stimulus (US), ususally a shock) and a neutral stimulus (the conditioned stimulus (CS), usually an auditory cue or light)" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Npas1tm1Slm/Npas1tm1Slm,Npas3tm1Slm/Npas3tm1Slm
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0001486 abnormal startle reflex "abberant threshold or reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, What s Wrong With My Mouse?:ISBN 0-471-31639-3]
Show

Allelic Composition: Fgf8tm1.3Mrt/Fgf8tm1.4Mrt,Tg(T-cre)1Lwd/0
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6 * CD-1

 MP:0001513 limb grasping "mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Fgf8tm1.3Mrt/Fgf8tm1.4Mrt,Tg(T-cre)1Lwd/0
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6 * CD-1

 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
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Allelic Composition: Fcamrtm2Shib/Fcamrtm2Shib
Genetic Background: BALB/c-Fcamrtm2Shib

 MP:0001954 respiratory distress "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
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Allelic Composition: Fcamrtm2Shib/Fcamrtm2Shib
Genetic Background: BALB/c-Fcamrtm2Shib

 MP:0001958 emphysema "lung disease characterized by increased size of terminal bronchioles with destructive changes in their walls and reduction in number" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33629]
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Allelic Composition: Fcamrtm2Shib/Fcamrtm2Shib
Genetic Background: BALB/c-Fcamrtm2Shib

 MP:0001961 abnormal reflex "anomalies in an involuntary response to a peripheral stimulus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Fgf8tm1.3Mrt/Fgf8tm1.4Mrt,Tg(T-cre)1Lwd/0
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6 * CD-1

 MP:0003088 abnormal prepulse inhibition "increase or decrease in the ability of a relatively mild stimulus to suppress the response to a strong, startle-eliciting stimulus" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91131]
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Allelic Composition: Npas1tm1Slm/Npas1tm1Slm,Npas3tm1Slm/Npas3tm1Slm
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0003107 abnormal response to novelty "alteration in amount of exploration/investigation of a novel object, situation or environment" [CFG:Center for Functional Genomics, Northwestern University]
Show

Allelic Composition: Npas3tm1Ewb/Npas3tm1Ewb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003461 abnormal response to novel object "altered investigative behavior from controls in reactions associated with exposing an animal to a novel object" [CFG:Center for Functional Genomics, Northwestern University]
Show

Allelic Composition: Npas3tm1Ewb/Npas3tm1Ewb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004007 abnormal lung vasculature "malformation or disorganization of the blood vessels of the lung" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Npas3tm1Mesu/Npas3+
Genetic Background: B6.129S6-Npas3tm1Mesu

 MP:0004167 abnormal cingulate gyrus morphology "any malformation or absence of the ridge in the cerebral cortex located dorsal to the corpus callosum that controls autonomic functions regulating heart rate and blood pressure as well as cognitive and attentional processing" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Npas3tm1Ewb/Npas3tm1Ewb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005537 abnormal cerebral aqueduct "anomalous structure of the channel in the mesencephalon that connets the third and fourth ventricles" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Npas3tm1Ewb/Npas3tm1Ewb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0006027 impaired alveologenesis "a block or reduction in the generation of alveoli" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:85546]
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Allelic Composition: Npas3tm1Mesu/Npas3+
Genetic Background: B6.129S6-Npas3tm1Mesu

 MP:0008534 enlarged fourth ventricle "increased size of the irregularly shaped cavity in the rhombencephalon, between the medulla oblongata, the pons, and the isthmus in front, and the cerebellum behind; it is continuous with the central canal of the cord below and with the cerebral aqueduct above, and through its lateral and median apertures it communicates with the subarachnoid space" [MESH:A08.186.211.276.500, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Npas3tm1Ewb/Npas3tm1Ewb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008535 enlarged lateral ventricles "increased size of the cavity in each of the cerebral hemispheres derived from the cavity of the embryonic neural tube; they are separated from each other by the septum pellucidum, and each communicates with the third ventricle by the foramen of Monro, through which also the choroid plexuses of the lateral ventricles become continuous with that of the third ventricle" [MESH:A08.186.211.276.650, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Npas3tm1Ewb/Npas3tm1Ewb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008536 enlarged third ventricle "increased size of the narrow cleft inferior to the corpus callosum, within the diencephalon, between the paired thalami; its floor is formed by the hypothalamus, its anterior wall by the lamina terminalis, and its roof by ependyma; it communicates with the fourth ventricle by the cerebral aqueduct, and with the lateral ventricles by the interventricular foramina" [MESH:A08.186.211.276.840, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Npas3tm1Ewb/Npas3tm1Ewb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009745 abnormal behavioral response to xenobiotic "any anomaly in the behavioral response induced by a foreign compound, such as consumption preference, induced hyperactivity or stereotypic behavior" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Npas3tm1Ewb/Npas3tm1Ewb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0010856 dilated respiratory conducting tubes "expansion or widening of the lumens of the tubes of the respiratory system that allow passage of air from the trachea to the alveoli of the lungs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fcamrtm2Shib/Fcamrtm2Shib
Genetic Background: BALB/c-Fcamrtm2Shib

 MP:0010901 abnormal pulmonary alveolar parenchyma morphology "any structural anomaly of the distinguishing cell types of the lung alveolar tissue, including pulmonary epithelial cells (pneumocytes), alveolar capillary endothelial cells, interstitial cells (fibroblasts) and alveolar macrophages" [ISBN:070202788 "Saunders Comprehensive Veterinary Dictionary, 3rd edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fcamrtm2Shib/Fcamrtm2Shib
Genetic Background: BALB/c-Fcamrtm2Shib

 MP:0010935 increased airway resistance "greater opposition to flow of air caused by the forces of friction, measured as the ratio of driving pressure to the rate of air flow" [MGI:csmith]
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Allelic Composition: Npas3tm1Mesu/Npas3+
Genetic Background: B6.129S6-Npas3tm1Mesu

 MP:0011012 bronchiectasis "a chronic inflammatory or degenerative condition marked by permanent dilatation (widening) of one or more bronchi and loss of elasticity of the bronchial walls" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Fcamrtm2Shib/Fcamrtm2Shib
Genetic Background: BALB/c-Fcamrtm2Shib

 MP:0011026 impaired branching involved in trachea morphogenesis 
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Allelic Composition: Fcamrtm2Shib/Fcamrtm2Shib
Genetic Background: BALB/c-Fcamrtm2Shib

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Fcamrtm2Shib/Fcamrtm2Shib
Genetic Background: BALB/c-Fcamrtm2Shib

 MP:0012489 abnormal retrosplenial region morphology "any structural anomaly of one of the key brain regions required for cognitive functions, including episodic memory, navigation, imagination and planning for the future; the retrosplenial region can be divided into three parts, the retrosplenial granular cortex A, the retrosplenial granular cortex B and the retrosplenial dysgranular cortex; each subdivision of the retrosplenial cortex projects to a discrete terminal field in the hippocampal formation" [PMID:1308170, PMID:19812579]
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Allelic Composition: Npas3tm1Ewb/Npas3tm1Ewb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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