ENSG00000007047


Homo sapiens

Features
Gene ID: ENSG00000007047
  
Biological name :MARK4
  
Synonyms : MARK4 / microtubule affinity regulating kinase 4 / Q96L34
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: 1
Band: q13.32
Gene start: 45079288
Gene end: 45305283
  
Corresponding Affymetrix probe sets: 221560_at (Human Genome U133 Plus 2.0 Array)   55065_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000484974
Ensembl peptide - ENSP00000466843
Ensembl peptide - ENSP00000480702
Ensembl peptide - ENSP00000262891
Ensembl peptide - ENSP00000300843
Ensembl peptide - ENSP00000465414
Ensembl peptide - ENSP00000465613
Ensembl peptide - ENSP00000466702
NCBI entrez gene - 57787     See in Manteia.
OMIM - 606495
RefSeq - XM_006723307
RefSeq - NM_001199867
RefSeq - NM_031417
RefSeq Peptide - NP_001186796
RefSeq Peptide - NP_113605
swissprot - Q6IPE9
swissprot - Q96GZ3
swissprot - K7EKG8
swissprot - Q96L34
swissprot - K7EN95
swissprot - K7EK17
Ensembl - ENSG00000007047
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 MARK4ENSDARG00000024966Danio rerio
 mark4aENSDARG00000023914Danio rerio
 Mark4ENSMUSG00000030397Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MARK3 / P27448 / microtubule affinity regulating kinase 3ENSG0000007541363
MARK1 / Q9P0L2 / microtubule affinity regulating kinase 1ENSG0000011614159
MARK2 / Q7KZI7 / microtubule affinity regulating kinase 2ENSG0000007251856
SIK3 / SIK family kinase 3ENSG0000016058434
SIK2 / Q9H0K1 / salt inducible kinase 2ENSG0000017014531
SIK1 / P57059 / salt inducible kinase 1ENSG0000014217831
SIK1B / salt inducible kinase 1B (putative)ENSG0000027599331
SNRK / Q9NRH2 / SNF related kinaseENSG0000016378827
NIM1K / Q8IY84 / NIM1 serine/threonine protein kinaseENSG0000017745320


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001772  Kinase associated domain 1 (KA1)
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR015940  Ubiquitin-associated domain
 IPR017441  Protein kinase, ATP binding site
 IPR028375  KA1 domain/Ssp2, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000082 G1/S transition of mitotic cell cycle NAS
 biological_processGO:0000086 G2/M transition of mitotic cell cycle NAS
 biological_processGO:0000226 microtubule cytoskeleton organization IEA
 biological_processGO:0001578 microtubule bundle formation IEP
 biological_processGO:0006468 protein phosphorylation NAS
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007399 nervous system development IDA
 biological_processGO:0008284 positive regulation of cell proliferation IDA
 biological_processGO:0016055 Wnt signaling pathway TAS
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0030010 establishment of cell polarity IEA
 biological_processGO:0030030 cell projection organization IEA
 biological_processGO:0043068 positive regulation of programmed cell death NAS
 biological_processGO:0051301 cell division IEA
 biological_processGO:0097711 ciliary basal body-plasma membrane docking TAS
 cellular_componentGO:0000930 gamma-tubulin complex IDA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005813 centrosome IDA
 cellular_componentGO:0005815 microtubule organizing center IDA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005874 microtubule IDA
 cellular_componentGO:0015630 microtubule cytoskeleton IDA
 cellular_componentGO:0036064 ciliary basal body IMP
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043005 neuron projection IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity NAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008017 microtubule binding IDA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0043015 gamma-tubulin binding IDA
 molecular_functionGO:0043130 ubiquitin binding NAS
 molecular_functionGO:0050321 tau-protein kinase activity IDA


Pathways (from Reactome)
Pathway description
Anchoring of the basal body to the plasma membrane


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000128881 TTBK2 / Q6IQ55 / tau tubulin kinase 2  / complex / reaction






 

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