| MP:0000109 | abnormal parietal bone morphology | "malformed curved bone forming part of the vault of the cranium" [J:17489] |
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Allelic Composition: Pla2g6m1J/Pla2g6m1J
Genetic Background: C3H/HeJ-Pla2g6m1J
|
| MP:0000150 | abnormal rib morphology | "malformed bones forming the bony wall of the chest" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:50311] |
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Allelic Composition: Pla2g6m1J/Pla2g6m1J
Genetic Background: C3H/HeJ-Pla2g6m1J
|
| MP:0000161 | scoliosis | "lateral and rotational curvature of the spine" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:53770, J:66943] |
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Allelic Composition: Pla2g6m1J/Pla2g6m1J
Genetic Background: C3H/HeJ-Pla2g6m1J
|
| MP:0000163 | abnormal cartilage morphology | "anomalous structure or development of the nonvascular, resilient, flexible connective tissue found primarily in joints, walls of the throax, and tubular structures, but which also comprises most of the skeleton in early fetal life " [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Pla2g6m1J/Pla2g6m1J
Genetic Background: C3H/HeJ-Pla2g6m1J
|
| MP:0000167 | reduced chondrocyte numbers | "fewer than normal numbers of nondividing cartilage cells" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:61509] |
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Allelic Composition: Pla2g6m1J/Pla2g6m1J
Genetic Background: C3H/HeJ-Pla2g6m1J
|
| MP:0000186 | decreased circulating HDL cholesterol level | "lower than average level of high density lipoprotein in blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
Show
Allelic Composition: Sik3tm1Htake/Sik3tm1Htake
Genetic Background: involves: C57BL/6JJcl * C57BL/6N
|
| MP:0000598 | abnormal liver morphology | "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170] |
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Allelic Composition: Wastm1Sbs/Y
Genetic Background: involves: 129S6/SvEvTac * C57BL/6
|
| MP:0000607 | abnormal hepatocyte morphology | "malformation of the main structural component of the liver; these are specialized epithelial cells normally organize into interconnected plates called lobules" [J:23170, MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Wastm1Sbs/Y
Genetic Background: involves: 129S6/SvEvTac * C57BL/6
|
| MP:0000610 | cholestasis | "impairment of bile flow due to obstruction in small bile ducts (intrahepatic cholestasis) or obstruction in large bile ducts (extrahepatic cholestasis)" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
Show
Allelic Composition: Sik3tm1Htake/Sik3tm1Htake
Genetic Background: involves: C57BL/6JJcl * C57BL/6N
|
| MP:0001262 | decreased body weight | "lower than normal average weight " [J:61295] |
Show
Allelic Composition: Pla2g6m1J/Pla2g6m1J
Genetic Background: C3H/HeJ-Pla2g6m1J
Allelic Composition: Sik3tm1Htake/Sik3tm1Htake
Genetic Background: involves: C57BL/6JJcl * C57BL/6N
|
| MP:0001265 | reduced body size | "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170] |
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Allelic Composition: Pla2g6m1J/Pla2g6m1J
Genetic Background: C3H/HeJ-Pla2g6m1J
|
| MP:0001431 | abnormal eating behavior | "inability to consume or atypical consumption pattern" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:19212] |
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Allelic Composition: Wastm1Sbs/Y
Genetic Background: involves: 129S6/SvEvTac * C57BL/6
|
| MP:0001501 | abnormal sleep pattern | "deviation from the normal wake/sleep cycle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: NalcnDrl/Nalcn+
Genetic Background: involves: C57BL/6J * C57BL/6N
Allelic Composition: Sik3Slp/Sik3Slp
Genetic Background: involves: C57BL/6J * C57BL/6N
Allelic Composition: Sik3tm1.1Iiis/Sik3+
Genetic Background: involves: C57BL/6N
Allelic Composition: Sik3em1Iiis/Sik3+
Genetic Background: involves: C57BL/6J
|
| MP:0001552 | increased circulating triglyceride level | "higher than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:65416] |
Show
Allelic Composition: Sik3tm1Htake/Sik3tm1Htake
Genetic Background: involves: C57BL/6JJcl * C57BL/6N
|
| MP:0001764 | abnormal homeostasis | "anomaly in the state of equilibrium in the body with respect to various functions and to chemical composition of the fluids and tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
Show
Allelic Composition: Wastm1Sbs/Y
Genetic Background: involves: 129S6/SvEvTac * C57BL/6
|
| MP:0001780 | decreased brown fat amount | "reduced quantity of this thermogenic form of adipose tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Wastm1Sbs/Y
Genetic Background: involves: 129S6/SvEvTac * C57BL/6
|
| MP:0002078 | abnormal glucose homeostasis | "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Wastm1Sbs/Y
Genetic Background: involves: 129S6/SvEvTac * C57BL/6
|
| MP:0002118 | abnormal lipid homeostasis | "anomaly in the state of equilibrium in the body with respect to lipids in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Wastm1Sbs/Y
Genetic Background: involves: 129S6/SvEvTac * C57BL/6
|
| MP:0002310 | resistance to fatty liver development | "less likely than the norm to to develop hepatic steatosis " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Sik3tm1Htake/Sik3tm1Htake
Genetic Background: involves: C57BL/6JJcl * C57BL/6N
|
| MP:0002644 | decreased circulating triglyceride level | "lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Sik3tm1Htake/Sik3tm1Htake
Genetic Background: involves: C57BL/6JJcl * C57BL/6N
|
| MP:0002727 | decreased circulating insulin level | "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Sik3tm1Htake/Sik3tm1Htake
Genetic Background: involves: C57BL/6JJcl * C57BL/6N
|
| MP:0002896 | abnormal bone mineralization | "defect in the process by which minerals are deposited into bone" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Pla2g6m1J/Pla2g6m1J
Genetic Background: C3H/HeJ-Pla2g6m1J
|
| MP:0002941 | increased circulating alanine transaminase level | "increased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
Show
Allelic Composition: Sik3tm1Htake/Sik3tm1Htake
Genetic Background: involves: C57BL/6JJcl * C57BL/6N
|
| MP:0002942 | decreased circulating alanine transaminase level | "decreased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
Show
Allelic Composition: Sik3tm1Htake/Sik3tm1Htake
Genetic Background: involves: C57BL/6JJcl * C57BL/6N
|
| MP:0002968 | increased circulating alkaline phosphatase level | "elevated activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Sik3tm1Htake/Sik3tm1Htake
Genetic Background: involves: C57BL/6JJcl * C57BL/6N
|
| MP:0003116 | rickets | "overproduction and deficient calcification of osteoid tissue due to vitamin D deficiency; can lead to skeletal deformities, growth defects, hypocalcemia, and sometimes tetany; skeletal fractures occur frequently" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator] |
Show
Allelic Composition: Pla2g6m1J/Pla2g6m1J
Genetic Background: C3H/HeJ-Pla2g6m1J
|
| MP:0003402 | decreased liver weight | "reduced average weight of the bile-secreting exocrine gland" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Sik3tm1Htake/Sik3tm1Htake
Genetic Background: involves: C57BL/6JJcl * C57BL/6N
|
| MP:0003409 | decreased width of hypertrophic chondrocyte zone | "decreased width of cartilage cell matrix layer " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Pla2g6m1J/Pla2g6m1J
Genetic Background: C3H/HeJ-Pla2g6m1J
|
| MP:0003420 | delayed intramembranous bone ossification | "late onset of bone formation in bones that form without a cartilagenous intermediate including the cranium and clavicle" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:94631] |
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Allelic Composition: Pla2g6m1J/Pla2g6m1J
Genetic Background: C3H/HeJ-Pla2g6m1J
|
| MP:0003795 | abnormal bone structure | |
Show
Allelic Composition: Pla2g6m1J/Pla2g6m1J
Genetic Background: C3H/HeJ-Pla2g6m1J
|
| MP:0003918 | decreased kidney weight | "reduced heft of the organs responsible for urine secretion" [RGD:Rat Genome Database submission] |
Show
Allelic Composition: Sik3tm1Htake/Sik3tm1Htake
Genetic Background: involves: C57BL/6JJcl * C57BL/6N
|
| MP:0003947 | abnormal cholesterol level | "anomaly in the concentration in the body of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
Show
Allelic Composition: Sik3tm1Htake/Sik3tm1Htake
Genetic Background: involves: C57BL/6JJcl * C57BL/6N
|
| MP:0003976 | decreased circulating VLDL triglyceride level | "lower than average concentration in the blood of very low density lipoprotein, which normally transports triglycerides from the intestine and liver to muscle and adipose tissue" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator] |
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Allelic Composition: Sik3tm1Htake/Sik3tm1Htake
Genetic Background: involves: C57BL/6JJcl * C57BL/6N
|
| MP:0003983 | decreased cholesterol level | "less than normal concentration in the body of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
Show
Allelic Composition: Sik3tm1Htake/Sik3tm1Htake
Genetic Background: involves: C57BL/6JJcl * C57BL/6N
|
| MP:0004321 | short sternum | "reduced length of the long flat bone of the chest which articulates with clavicle and first seven rib pairs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Pla2g6m1J/Pla2g6m1J
Genetic Background: C3H/HeJ-Pla2g6m1J
|
| MP:0004509 | abnormal pelvic girdle bone morphology | "any structural anomaly of the bones of the pelvis by which the limbs attach to the axial skeleton " [MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Pla2g6m1J/Pla2g6m1J
Genetic Background: C3H/HeJ-Pla2g6m1J
|
| MP:0004672 | short ribs | "reduced length of the bones forming the bony wall of the chest" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Pla2g6m1J/Pla2g6m1J
Genetic Background: C3H/HeJ-Pla2g6m1J
|
| MP:0004686 | decreased length of long bones | "reduced end-to-end length of the several elongated bones of the extremities" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Pla2g6m1J/Pla2g6m1J
Genetic Background: C3H/HeJ-Pla2g6m1J
|
| MP:0004703 | abnormal vertebral column | "any structural anomaly of the complete structure forming the rostral-caudal axis of the skeleton formed from the alternating segments of vertebra and intervertebral discs which support the spinal cord" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Pla2g6m1J/Pla2g6m1J
Genetic Background: C3H/HeJ-Pla2g6m1J
|
| MP:0004777 | abnormal phospholipid level | "anomalous concentration of the fat derivatives in which one fatty acid has been replaced by a phosphate group" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Sik3tm1Htake/Sik3tm1Htake
Genetic Background: involves: C57BL/6JJcl * C57BL/6N
|
| MP:0004789 | increased bile salt level | "increased concentration of the steroid salts derived from cholesterol in the liver, produced as bile acids and secreted in the biliary sytem as bile salts; these play an important role in the digestion and absorption of fats" [MESH:D04.808.105, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Sik3tm1Htake/Sik3tm1Htake
Genetic Background: involves: C57BL/6JJcl * C57BL/6N
|
| MP:0004892 | increased adiponectin level | "greater level of a protein hormone that regulates glucose homeostasis and metabolism of lipids; it is normally produced by adipose tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Sik3tm1Htake/Sik3tm1Htake
Genetic Background: involves: C57BL/6JJcl * C57BL/6N
|
| MP:0004994 | abnormal brain wave pattern | "any anomaly in the standard pattern of rhythmic and rapid fluctuation of electrical potential between parts of the brain, often visualized on an electroencephalogram (EEG); the pattern is often measured to diagnose neurological conditions such as seizure disorders (epilepsy)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: NalcnDrl/Nalcn+
Genetic Background: involves: C57BL/6J * C57BL/6N
Allelic Composition: Sik3Slp/Sik3Slp
Genetic Background: involves: C57BL/6J * C57BL/6N
|
| MP:0005084 | abnormal gall bladder morphology | "anomalous structure or development of the organ which serves as a storage reservoir for bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
Show
Allelic Composition: Sik3tm1Htake/Sik3tm1Htake
Genetic Background: involves: C57BL/6JJcl * C57BL/6N
|
| MP:0005179 | decreased total circulating cholesterol level | "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
Show
Allelic Composition: Sik3tm1Htake/Sik3tm1Htake
Genetic Background: involves: C57BL/6JJcl * C57BL/6N
|
| MP:0005289 | increased oxygen consumption | "greater than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
Show
Allelic Composition: Sik3tm1Htake/Sik3tm1Htake
Genetic Background: involves: C57BL/6JJcl * C57BL/6N
|
| MP:0005292 | improved glucose tolerance | "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
Show
Allelic Composition: Sik3tm1Htake/Sik3tm1Htake
Genetic Background: involves: C57BL/6JJcl * C57BL/6N
|
| MP:0005344 | increased circulating bilirubin level | "greater than the normal concentration in the blood of this yellow heme breakdown product" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85204] |
Show
Allelic Composition: Sik3tm1Htake/Sik3tm1Htake
Genetic Background: involves: C57BL/6JJcl * C57BL/6N
|
| MP:0005415 | intrahepatic cholestasis | "impariment of bile flow due to injury to the hepatocytes, bile canaliculi, or the intrahepatic bile ducts" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
Show
Allelic Composition: Sik3tm1Htake/Sik3tm1Htake
Genetic Background: involves: C57BL/6JJcl * C57BL/6N
|
| MP:0005416 | abnormal circulating protein level | "anomalous blood concentration of any of the macromolecules consisting of long chains of amino acids in peptide linkage" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
Show
Allelic Composition: Sik3tm1Htake/Sik3tm1Htake
Genetic Background: involves: C57BL/6JJcl * C57BL/6N
|
| MP:0005418 | abnormal circulating hormone level | "anomalous blood concentration of any of the chemical substances that have specific regulatory effects on the activity of a certain organ or organs; originally applied to substances secreted by various endocrine glands and transported in the bloodstream to the target organs, it is sometimes extended to include substances that are not produced by the endocrine glands but that have similar effects" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Sik3tm1Htake/Sik3tm1Htake
Genetic Background: involves: C57BL/6JJcl * C57BL/6N
|
| MP:0005448 | abnormal energy balance | "aberrant intake or expenditure of calories as compared to the normal state" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Sik3tm1Htake/Sik3tm1Htake
Genetic Background: involves: C57BL/6JJcl * C57BL/6N
|
| MP:0005508 | abnormal skeleton morphology | "malformation of the bony framework of the body in vertebrates" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
Show
Allelic Composition: Pla2g6m1J/Pla2g6m1J
Genetic Background: C3H/HeJ-Pla2g6m1J
|
| MP:0005560 | decreased circulating glucose level | "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Sik3tm1Htake/Sik3tm1Htake
Genetic Background: involves: C57BL/6JJcl * C57BL/6N
|
| MP:0005659 | resistance to diet-induced obesity | "less likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator] |
Show
Allelic Composition: Sik3tm1Htake/Sik3tm1Htake
Genetic Background: involves: C57BL/6JJcl * C57BL/6N
|
| MP:0005668 | decreased circulating leptin level | "less than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751] |
Show
Allelic Composition: Sik3tm1Htake/Sik3tm1Htake
Genetic Background: involves: C57BL/6JJcl * C57BL/6N
|
| MP:0006398 | increased long bone epiphyseal plate size | "greater than the normal size of the cartilaginous center of ossification on the long bones permitting growth of the bone in both directions during development" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Pla2g6m1J/Pla2g6m1J
Genetic Background: C3H/HeJ-Pla2g6m1J
|
| MP:0008844 | decreased subcutaneous adipose tissue amount | "reduction in amount of adipose tissue beneath the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Sik3tm1Htake/Sik3tm1Htake
Genetic Background: involves: C57BL/6JJcl * C57BL/6N
|
| MP:0009109 | decreased pancreas weight | "reduction in the average weight of the organ that secretes pancreatic juice into the duodenum and secretes glucagon and insulin into the bloodstream" [MESH:A03.734, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Sik3tm1Htake/Sik3tm1Htake
Genetic Background: involves: C57BL/6JJcl * C57BL/6N
|
| MP:0009269 | decreased fat cell size | "reduction in the size of fat-storing cells found mostly in the abdominal cavity and subcutaneous tissue of mammals" [CL:0000449] |
Show
Allelic Composition: Sik3tm1Htake/Sik3tm1Htake
Genetic Background: involves: C57BL/6JJcl * C57BL/6N
|
| MP:0009283 | decreased gonadal fat pad weight | "less than average weight of the encapsulated adipose tissue associated with the ovaries or testes" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Sik3tm1Htake/Sik3tm1Htake
Genetic Background: involves: C57BL/6JJcl * C57BL/6N
|
| MP:0009299 | decreased mesenteric fat pad weight | |
Show
Allelic Composition: Sik3tm1Htake/Sik3tm1Htake
Genetic Background: involves: C57BL/6JJcl * C57BL/6N
|
| MP:0009303 | decreased renal fat pad weight | |
Show
Allelic Composition: Sik3tm1Htake/Sik3tm1Htake
Genetic Background: involves: C57BL/6JJcl * C57BL/6N
|
| MP:0009342 | enlarged gall bladder | "increased size of the gall bladder, the organ that serves as a storage reservoir for bile" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Sik3tm1Htake/Sik3tm1Htake
Genetic Background: involves: C57BL/6JJcl * C57BL/6N
|
| MP:0009356 | decreased liver triglyceride level | "lower than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Sik3tm1Htake/Sik3tm1Htake
Genetic Background: involves: C57BL/6JJcl * C57BL/6N
|
| MP:0009492 | abnormal gall bladder epithelium morphology | "any structural anomaly of the simple columnar epithelial lining of the gall bladder" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Sik3tm1Htake/Sik3tm1Htake
Genetic Background: involves: C57BL/6JJcl * C57BL/6N
|
| MP:0010026 | decreased liver cholesterol level | "less than normal amount in the liver of the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones; it is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Sik3tm1Htake/Sik3tm1Htake
Genetic Background: involves: C57BL/6JJcl * C57BL/6N
|
| MP:0010027 | increased liver cholesterol level | "greater than normal amount in the liver of the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones; it is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Sik3tm1Htake/Sik3tm1Htake
Genetic Background: involves: C57BL/6JJcl * C57BL/6N
|
| MP:0010378 | increased respiratory quotient | "increase in the ratio of the volume of carbon dioxide released to oxygen consumed by a body tissue or an organism compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Sik3tm1Htake/Sik3tm1Htake
Genetic Background: involves: C57BL/6JJcl * C57BL/6N
|
| MP:0010743 | delayed suture closure | "late onset of the fusion of the bones of the skull" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Pla2g6m1J/Pla2g6m1J
Genetic Background: C3H/HeJ-Pla2g6m1J
|
| MP:0011016 | increased core body temperature | "increased degree of heat natural to the internal center of a living being" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Sik3tm1Htake/Sik3tm1Htake
Genetic Background: involves: C57BL/6JJcl * C57BL/6N
|
| MP:0011088 | partial neonatal lethality | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith] |
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Allelic Composition: Pla2g6m1J/Pla2g6m1J
Genetic Background: C3H/HeJ-Pla2g6m1J
Allelic Composition: Sik3tm1Htake/Sik3tm1Htake
Genetic Background: involves: C57BL/6N
Allelic Composition: Sik3tm1Htake/Sik3tm1Htake
Genetic Background: involves: C57BL/6JJcl * C57BL/6N
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| MP:0011168 | abnormal fat cell differentiation | "abnormal or arrest of differentiation of fat-storing cells found mostly in the abdominal cavity and subcutaneous tissue of mammals" [CL:0000449, MGI:csmith] |
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Allelic Composition: Sik3tm1Htake/Sik3tm1Htake
Genetic Background: involves: C57BL/6JJcl * C57BL/6N
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| MP:0011234 | abnormal retinol level | "any anomaly in the concentration of retinol, which plays an essential role in metabolic functioning of the retina, and growth and differentiation" [ISBN:0-683-40008-8] |
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Allelic Composition: Sik3tm1Htake/Sik3tm1Htake
Genetic Background: involves: C57BL/6JJcl * C57BL/6N
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| MP:0011504 | abnormal limb long bone morphology | |
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Allelic Composition: Sik3tm1Htake/Sik3tm1Htake
Genetic Background: involves: C57BL/6N
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| MP:0012288 | abnormal paradoxical sleep pattern | "any anomaly in the frequency or duration of the sleep stage in which dreams occur and the body undergoes marked changes including rapid eye movement, loss of reflexes, and increased pulse rate and brain activity" [MGI:csmith] |
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Allelic Composition: NalcnDrl/Nalcn+
Genetic Background: involves: C57BL/6J * C57BL/6N
Allelic Composition: Sik3Slp/Sik3Slp
Genetic Background: involves: C57BL/6J * C57BL/6N
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| MP:0012289 | abnormal non-rapid eye movement sleep pattern | "any anomaly in the frequency or duration of the sleep stages characterized by distinct EEG patterns, decreased metabolic activity, slowed breathing and heart rate, and the absence of rapid eye movement and dreaming" [MGI:csmith] |
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Allelic Composition: NalcnDrl/Nalcn+
Genetic Background: involves: C57BL/6J * C57BL/6N
Allelic Composition: Sik3Slp/Sik3Slp
Genetic Background: involves: C57BL/6J * C57BL/6N
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| MP:0020478 | abnormal circadian sleep/wake cycle | "any anomaly in the cycle from wakefulness through an orderly succession of sleep states and stages that occurs on an approximately 24 hour rhythm" [GO:0042745] |
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Allelic Composition: NalcnDrl/Nalcn+
Genetic Background: involves: C57BL/6J * C57BL/6N
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| MP:0030388 | large fontanelles | "an abnormally increased size of one or more fontanelles for age-related norms, generally resulting from delayed or incomplete fontanelle closure" [HP:0000239, MGI:anna] |
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Allelic Composition: Sik3tm1Htake/Sik3tm1Htake
Genetic Background: involves: C57BL/6N
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