ENSMUSG00000024042


Mus musculus

Features
Gene ID: ENSMUSG00000024042
  
Biological name :Sik1
  
Synonyms : Q60670 / Serine/threonine-protein kinase SIK1 / Sik1
  
Possible biological names infered from orthology : P57059 / salt inducible kinase 1 / salt inducible kinase 1B (putative) / SIK1B
  
Species: Mus musculus
  
Chr. number: 17
Strand: -1
Band: B1
Gene start: 31844248
Gene end: 31855792
  
Corresponding Affymetrix probe sets: 10449741 (MoGene1.0st)   1419766_at (Mouse Genome 430 2.0 Array)   1459601_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000024839
NCBI entrez gene - 17691     See in Manteia.
MGI - MGI:104754
RefSeq - NM_010831
RefSeq Peptide - NP_034961
swissprot - Q60670
Ensembl - ENSMUSG00000024042
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sik1ENSDARG00000058606Danio rerio
 SIK1ENSGALG00000041988Gallus gallus
 SIK1ENSG00000142178Homo sapiens
 SIK1BENSG00000275993Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Sik2 / salt inducible kinase 2 / Q9H0K1*ENSMUSG0000003711247
Sik3 / SIK family kinase 3ENSMUSG0000003413538
Mark4 / Q8CIP4 / MAP/microtubule affinity-regulating kinase 4 / Q96L34* / microtubule affinity regulating kinase 4*ENSMUSG0000003039729
Mark1 / Q8VHJ5 / Serine/threonine-protein kinase MARK1 / Q9P0L2* / microtubule affinity regulating kinase 1*ENSMUSG0000002662029
Mark3 / Q03141 / MAP/microtubule affinity-regulating kinase 3 / P27448* / microtubule affinity regulating kinase 3*ENSMUSG0000000741129
Mark2 / microtubule affinity regulating kinase 2 / Q7KZI7*ENSMUSG0000002496928
Snrk / Q8VDU5 / Mus musculus SNF related kinase (Snrk), transcript variant 5, mRNA. / Q9NRH2* / SNF related kinase*ENSMUSG0000003814523
Nim1k / Q8BHI9 / Serine/threonine-protein kinase NIM1 / Q8IY84* / NIM1 serine/threonine protein kinase*ENSMUSG0000009593018


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR015940  Ubiquitin-associated domain
 IPR017090  Serine/threonine-protein kinase, SIK1/2
 IPR017441  Protein kinase, ATP binding site
 IPR034672  Salt-Inducible kinase, catalytic domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0002028 regulation of sodium ion transport IEA
 biological_processGO:0006468 protein phosphorylation IDA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007346 regulation of mitotic cell cycle IDA
 biological_processGO:0010830 regulation of myotube differentiation IDA
 biological_processGO:0010868 negative regulation of triglyceride biosynthetic process IDA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0032792 negative regulation of CREB transcription factor activity IMP
 biological_processGO:0032870 cellular response to hormone stimulus IBA
 biological_processGO:0035556 intracellular signal transduction IDA
 biological_processGO:0043153 entrainment of circadian clock by photoperiod IMP
 biological_processGO:0043276 anoikis IMP
 biological_processGO:0045595 regulation of cell differentiation IEP
 biological_processGO:0045721 negative regulation of gluconeogenesis IDA
 biological_processGO:0046777 protein autophosphorylation ISS
 biological_processGO:0048511 rhythmic process IEA
 biological_processGO:0055007 cardiac muscle cell differentiation IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000287 magnesium ion binding IDA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IDA
 molecular_functionGO:0008140 cAMP response element binding protein binding IDA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0042826 histone deacetylase binding IPI
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0071889 14-3-3 protein binding ISS


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Rpgrip1ltm1a(EUCOMM)Wtsi/Rpgrip1ltm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Rpgrip1ltm1a(EUCOMM)Wtsi/Wtsi

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Plekhm2tm1a(EUCOMM)Wtsi/Plekhm2tm1a(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6J * C57BL/6N

Allelic Composition: Sik1tm1.2Berd/Sik1tm1.2Berd
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6J * SJL

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Plekhm2tm1a(EUCOMM)Wtsi/Plekhm2tm1a(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6J * C57BL/6N

Allelic Composition: Sik1tm1.2Berd/Sik1tm1.2Berd
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6J * SJL

 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Sik1tm1.2Berd/Sik1tm1.2Berd
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6J * SJL

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
Show

Allelic Composition: Plekhm2tm1a(EUCOMM)Wtsi/Plekhm2tm1a(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0002833 increased heart weight "greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Rpgrip1ltm1a(EUCOMM)Wtsi/Rpgrip1ltm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Rpgrip1ltm1a(EUCOMM)Wtsi/Wtsi

 MP:0002891 increased insulin sensitivity "greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Myf5tm3(cre)Sor/Myf5+,Sik1tm1.1Berd/Sik1tm1.1Berd
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6J * SJL

Allelic Composition: Sik1tm1.2Berd/Sik1tm1.2Berd
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6J * SJL

 MP:0003383 abnormal gluconeogenesis "anomaly in the formation of glucose from noncarbohydrates, such as proteins or fat" [J:93896]
Show

Allelic Composition: Myf5tm3(cre)Sor/Myf5+,Sik1tm1.1Berd/Sik1tm1.1Berd
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6J * SJL

 MP:0003960 increased lean body mass "more than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
Show

Allelic Composition: Rpgrip1ltm1a(EUCOMM)Wtsi/Rpgrip1ltm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Rpgrip1ltm1a(EUCOMM)Wtsi/Wtsi

 MP:0003961 decreased lean body mass "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
Show

Allelic Composition: Rpgrip1ltm1a(EUCOMM)Wtsi/Rpgrip1ltm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Rpgrip1ltm1a(EUCOMM)Wtsi/Wtsi

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Rpgrip1ltm1a(EUCOMM)Wtsi/Rpgrip1ltm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Rpgrip1ltm1a(EUCOMM)Wtsi/Wtsi

Allelic Composition: Myf5tm3(cre)Sor/Myf5+,Sik1tm1.1Berd/Sik1tm1.1Berd
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6J * SJL

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Sik1tm1.2Berd/Sik1tm1.2Berd
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6J * SJL

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rpgrip1ltm1a(EUCOMM)Wtsi/Rpgrip1ltm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Rpgrip1ltm1a(EUCOMM)Wtsi/Wtsi

 MP:0010123 increased bone mineral content "elevation in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rpgrip1ltm1a(EUCOMM)Wtsi/Rpgrip1ltm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Rpgrip1ltm1a(EUCOMM)Wtsi/Wtsi

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Sik1tm1.2Berd/Sik1tm1.2Berd
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6J * SJL

 MP:0030021 increased muscle cell glucose uptake "increased ability of muscle cells to take in glucose" [MGI:anna]
Show

Allelic Composition: Myf5tm3(cre)Sor/Myf5+,Sik1tm1.1Berd/Sik1tm1.1Berd
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6J * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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