ENSG00000089234


Homo sapiens

Features
Gene ID: ENSG00000089234
  
Biological name :BRAP
  
Synonyms : BRAP / BRCA1 associated protein / Q7Z569
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: -1
Band: q24.12
Gene start: 111642146
Gene end: 111685986
  
Corresponding Affymetrix probe sets: 209922_at (Human Genome U133 Plus 2.0 Array)   209923_s_at (Human Genome U133 Plus 2.0 Array)   213473_at (Human Genome U133 Plus 2.0 Array)   41512_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000330813
Ensembl peptide - ENSP00000403524
NCBI entrez gene - 8315     See in Manteia.
OMIM - 604986
RefSeq - XM_017019995
RefSeq - NM_006768
RefSeq - XM_017019992
RefSeq - XM_017019993
RefSeq - XM_017019994
RefSeq - XM_005253944
RefSeq - XM_011538789
RefSeq Peptide - NP_006759
swissprot - Q7Z569
swissprot - J3KNN7
Ensembl - ENSG00000089234
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 brapENSDARG00000008560Danio rerio
 BRAPENSGALG00000004650Gallus gallus
 BrapENSMUSG00000029458Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001607  Zinc finger, UBP-type
 IPR001841  Zinc finger, RING-type
 IPR011422  BRCA1-associated 2
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR034932  BRAP2, RNA recognition motif
 IPR035979  RNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade IDA
 biological_processGO:0007265 Ras protein signal transduction IDA
 biological_processGO:0009968 negative regulation of signal transduction IDA
 biological_processGO:0016567 protein ubiquitination IDA
 cellular_componentGO:0000151 ubiquitin ligase complex IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0031965 nuclear membrane IDA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008139 nuclear localization sequence binding IDA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0061630 ubiquitin protein ligase activity IDA


Pathways (from Reactome)
Pathway description
RAF activation
Negative regulation of MAPK pathway
Signaling by moderate kinase activity BRAF mutants
Signaling by RAS mutants
Paradoxical activation of RAF signaling by kinase inactive BRAF


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000075413 MARK3 / P27448 / microtubule affinity regulating kinase 3  / reaction / complex
 ENSG00000133703 KRAS / P01116 / KRAS proto-oncogene, GTPase  / complex / reaction
 ENSG00000174775 HRAS / P01112 / HRas proto-oncogene, GTPase  / reaction / complex
 ENSG00000141068 KSR1 / Q8IVT5 / kinase suppressor of ras 1  / complex / reaction
 ENSG00000213281 NRAS / P01111 / NRAS proto-oncogene, GTPase  / reaction / complex






 

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