ENSMUSG00000029859


Mus musculus

Features
Gene ID: ENSMUSG00000029859
  
Biological name :Epha1
  
Synonyms : Epha1 / Ephrin type-A receptor 1 / Q60750
  
Possible biological names infered from orthology : EPH receptor A1 / P21709
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: B2.1
Gene start: 42358487
Gene end: 42373268
  
Corresponding Affymetrix probe sets: 10544417 (MoGene1.0st)   1422917_at (Mouse Genome 430 2.0 Array)   1432399_a_at (Mouse Genome 430 2.0 Array)   1432400_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000144763
Ensembl peptide - ENSMUSP00000073099
NCBI entrez gene - 13835     See in Manteia.
MGI - MGI:107381
RefSeq - NM_023580
RefSeq - XM_011241203
RefSeq Peptide - NP_076069
swissprot - A0A0N4SUP4
swissprot - Q60750
Ensembl - ENSMUSG00000029859
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 EPHA1ENSG00000146904Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Epha2 / Q03145 / Ephrin type-A receptor 2 ENSMUSG0000000644548
Epha7 / Q61772 / Ephrin type-A receptor 7 / Q15375* / EPH receptor A7*ENSMUSG0000002828945
Epha4 / Q03137 / Ephrin type-A receptor 4 / P54764* / EPH receptor A4*ENSMUSG0000002623544
Ephb1 / Q8CBF3 / Ephrin type-B receptor 1 / P54762* / EPH receptor B1*ENSMUSG0000003253743
Ephb3 / P54754 / Ephrin type-B receptor 3 / P54753* / EPH receptor B3*ENSMUSG0000000595843
Epha3 / EPH receptor A3 / P29320*ENSMUSG0000005250443
Epha6 / EPH receptor A6 / Q9UF33*ENSMUSG0000005554042
Ephb2 / P54763 / Ephrin type-B receptor 2 / P29323* / EPH receptor B2*ENSMUSG0000002866442
Epha8 / O09127 / Ephrin type-A receptor 8 / P29322* / EPH receptor A8*ENSMUSG0000002866140
Ephb4 / P54761 / Ephrin type-B receptor 4 / P54760* / EPH receptor B4*ENSMUSG0000002971040
Ephb6 / O08644 / Ephrin type-B receptor 6 / EPH receptor B6*ENSMUSG0000002986937
Epha5 / Q60629 / Ephrin type-A receptor 5 / P54756* / EPH receptor A5*ENSMUSG0000002924537


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001090  Ephrin receptor ligand binding domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR001426  Tyrosine-protein kinase, receptor class V, conserved site
 IPR001660  Sterile alpha motif domain
 IPR003961  Fibronectin type III
 IPR008266  Tyrosine-protein kinase, active site
 IPR008979  Galactose-binding-like domain superfamily
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR011009  Protein kinase-like domain superfamily
 IPR011641  Tyrosine-protein kinase ephrin type A/B receptor-like
 IPR013761  Sterile alpha motif/pointed domain superfamily
 IPR013783  Immunoglobulin-like fold
 IPR016257  Ephrin receptor type-A /type-B
 IPR017441  Protein kinase, ATP binding site
 IPR020635  Tyrosine-protein kinase, catalytic domain
 IPR021157  Cytochrome c1, transmembrane anchor, C-terminal
 IPR027936  Ephrin receptor, transmembrane domain
 IPR034251  Ephrin type-A receptor 1, ligand binding domain
 IPR036116  Fibronectin type III superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0001954 positive regulation of cell-matrix adhesion IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006469 negative regulation of protein kinase activity IEA
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007166 cell surface receptor signaling pathway IEA
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0030335 positive regulation of cell migration IEA
 biological_processGO:0030336 negative regulation of cell migration IEA
 biological_processGO:0034446 substrate adhesion-dependent cell spreading IEA
 biological_processGO:0043087 regulation of GTPase activity IEA
 biological_processGO:0045766 positive regulation of angiogenesis IEA
 biological_processGO:0046777 protein autophosphorylation IEA
 biological_processGO:0048013 ephrin receptor signaling pathway IEA
 biological_processGO:0051496 positive regulation of stress fiber assembly IDA
 biological_processGO:0090630 activation of GTPase activity IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0004714 transmembrane receptor protein tyrosine kinase activity IEA
 molecular_functionGO:0005003 ephrin receptor activity IEA
 molecular_functionGO:0005005 transmembrane-ephrin receptor activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019901 protein kinase binding IEA


Pathways (from Reactome)
Pathway description
EPH-Ephrin signaling
EPHA-mediated growth cone collapse
EPH-ephrin mediated repulsion of cells


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000585 kinked tail "a sharp bend or zig-zag in the tail" [J:61295]
Show

Allelic Composition: Tg(S100b-v-erbB)4496Waw/0,Trp53tm1Brd/Trp53+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * DBA/2J * FVB/N

 MP:0001144 fused vaginal opening "condition in which the external vaginal opening is closed by the adherence of the epithelium of the vagina" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tg(S100b-v-erbB)4496Waw/0,Trp53tm1Brd/Trp53+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * DBA/2J * FVB/N

 MP:0001270 distended abdomen "abdomen appears curved outward or swollen; can be due to skeletal axial defects, enlarged visceral organs or megacolon" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tg(S100b-v-erbB)4496Waw/0,Trp53tm1Brd/Trp53+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * DBA/2J * FVB/N

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
Show

Allelic Composition: Tg(S100b-v-erbB)4496Waw/0,Trp53tm1Brd/Trp53+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * DBA/2J * FVB/N

 MP:0003537 hydrometrocolops "collection of fluid in the vagina; often due to a congenital obstruction" [ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Tg(S100b-v-erbB)4496Waw/0,Trp53tm1Brd/Trp53+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * DBA/2J * FVB/N

 MP:0003541 vaginal inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the vagina" [ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Tg(S100b-v-erbB)4496Waw/0,Trp53tm1Brd/Trp53+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * DBA/2J * FVB/N

 MP:0003638 abnormal response/metabolism to endogenous compounds "altered ability or inability to metabolize or respond to substances normally present in the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tg(S100b-v-erbB)4496Waw/0,Trp53tm1Brd/Trp53+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * DBA/2J * FVB/N

 MP:0004904 increased uterus weight "increase in the weight of the female organ of gestation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tg(S100b-v-erbB)4496Waw/0,Trp53tm1Brd/Trp53+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * DBA/2J * FVB/N

 MP:0004906 enlarged uterus 
Show

Allelic Composition: Tg(S100b-v-erbB)4496Waw/0,Trp53tm1Brd/Trp53+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * DBA/2J * FVB/N

 MP:0009087 dilated uterine horn "an expansion in the volume or area of either one of the pair of tubular extensions from the uterine body where the uterus and the uterine tubes meet, usually with an increase in contained fluid" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tg(S100b-v-erbB)4496Waw/0,Trp53tm1Brd/Trp53+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * DBA/2J * FVB/N

 MP:0009360 endometrium inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the endometrium" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tg(S100b-v-erbB)4496Waw/0,Trp53tm1Brd/Trp53+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * DBA/2J * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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