ENSMUSG00000028661


Mus musculus

Features
Gene ID: ENSMUSG00000028661
  
Biological name :Epha8
  
Synonyms : Epha8 / Ephrin type-A receptor 8 / O09127
  
Possible biological names infered from orthology : EPH receptor A8 / P29322
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: D3
Gene start: 136929419
Gene end: 136956816
  
Corresponding Affymetrix probe sets: 10517521 (MoGene1.0st)   1419341_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000030420
NCBI entrez gene - 13842     See in Manteia.
MGI - MGI:109378
RefSeq - NM_007939
RefSeq Peptide - NP_031965
swissprot - O09127
Ensembl - ENSMUSG00000028661
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 EPHA8ENSGALG00000021567Gallus gallus
 EPHA8ENSG00000070886Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Epha7 / Q61772 / Ephrin type-A receptor 7 / Q15375* / EPH receptor A7*ENSMUSG0000002828956
Epha3 / EPH receptor A3 / P29320*ENSMUSG0000005250455
Epha4 / Q03137 / Ephrin type-A receptor 4 / P54764* / EPH receptor A4*ENSMUSG0000002623555
Epha6 / EPH receptor A6 / Q9UF33*ENSMUSG0000005554054
Ephb1 / Q8CBF3 / Ephrin type-B receptor 1 / P54762* / EPH receptor B1*ENSMUSG0000003253750
Ephb2 / P54763 / Ephrin type-B receptor 2 / P29323* / EPH receptor B2*ENSMUSG0000002866449
Ephb3 / P54754 / Ephrin type-B receptor 3 / P54753* / EPH receptor B3*ENSMUSG0000000595849
Epha5 / Q60629 / Ephrin type-A receptor 5 / P54756* / EPH receptor A5*ENSMUSG0000002924548
Epha2 / Q03145 / Ephrin type-A receptor 2 ENSMUSG0000000644545
Ephb4 / P54761 / Ephrin type-B receptor 4 / P54760* / EPH receptor B4*ENSMUSG0000002971044
Epha1 / Q60750 / Ephrin type-A receptor 1 / P21709* / EPH receptor A1*ENSMUSG0000002985939
Ephb6 / O08644 / Ephrin type-B receptor 6 / EPH receptor B6*ENSMUSG0000002986939


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001090  Ephrin receptor ligand binding domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR001426  Tyrosine-protein kinase, receptor class V, conserved site
 IPR001660  Sterile alpha motif domain
 IPR003961  Fibronectin type III
 IPR008266  Tyrosine-protein kinase, active site
 IPR008979  Galactose-binding-like domain superfamily
 IPR011009  Protein kinase-like domain superfamily
 IPR011641  Tyrosine-protein kinase ephrin type A/B receptor-like
 IPR013761  Sterile alpha motif/pointed domain superfamily
 IPR013783  Immunoglobulin-like fold
 IPR016257  Ephrin receptor type-A /type-B
 IPR017441  Protein kinase, ATP binding site
 IPR020635  Tyrosine-protein kinase, catalytic domain
 IPR020691  Ephrin type-A receptor 8
 IPR027936  Ephrin receptor, transmembrane domain
 IPR034287  Ephrin type-A receptor 8, ligand binding domain
 IPR036116  Fibronectin type III superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006929 substrate-dependent cell migration IDA
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0007411 axon guidance IMP
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0016322 neuron remodeling IDA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0030155 regulation of cell adhesion IDA
 biological_processGO:0031175 neuron projection development IDA
 biological_processGO:0033628 regulation of cell adhesion mediated by integrin IDA
 biological_processGO:0043410 positive regulation of MAPK cascade IDA
 biological_processGO:0043552 positive regulation of phosphatidylinositol 3-kinase activity IDA
 biological_processGO:0046777 protein autophosphorylation IDA
 biological_processGO:0048013 ephrin receptor signaling pathway IDA
 biological_processGO:0071372 cellular response to follicle-stimulating hormone stimulus IDA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031901 early endosome membrane IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043005 neuron projection IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0004714 transmembrane receptor protein tyrosine kinase activity IEA
 molecular_functionGO:0005003 ephrin receptor activity IEA
 molecular_functionGO:0005004 GPI-linked ephrin receptor activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
EPH-Ephrin signaling
EPHA-mediated growth cone collapse
EPH-ephrin mediated repulsion of cells


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000778 abnormal tract 
Show

Allelic Composition: Myd88tm1Aki/Myd88tm1Aki
Genetic Background: Not Specified

 MP:0002961 abnormal axon guidance "defect in the signaling mechanisms that allow precise navigation and connections of axonal growth cones to effector tissues " [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Myd88tm1Aki/Myd88tm1Aki
Genetic Background: Not Specified

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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