ENSMUSG00000029869


Mus musculus

Features
Gene ID: ENSMUSG00000029869
  
Biological name :Ephb6
  
Synonyms : Ephb6 / Ephrin type-B receptor 6 / O08644
  
Possible biological names infered from orthology : EPH receptor B6
  
Species: Mus musculus
  
Chr. number: 6
Strand: 1
Band: B2.1
Gene start: 41605482
Gene end: 41620509
  
Corresponding Affymetrix probe sets: 10537657 (MoGene1.0st)   1418051_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000110380
Ensembl peptide - ENSMUSP00000132773
Ensembl peptide - ENSMUSP00000133131
NCBI entrez gene - 13848     See in Manteia.
MGI - MGI:1096338
RefSeq - NM_007680
RefSeq - NM_001146351
RefSeq Peptide - NP_001139823
RefSeq Peptide - NP_031706
swissprot - O08644
swissprot - F6W657
swissprot - F6TDC5
Ensembl - ENSMUSG00000029869
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ephb6ENSDARG00000057729Danio rerio
 EPHB6ENSGALG00000014749Gallus gallus
 EPHB6ENSG00000106123Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ephb1 / Q8CBF3 / Ephrin type-B receptor 1 / P54762* / EPH receptor B1*ENSMUSG0000003253747
Ephb3 / P54754 / Ephrin type-B receptor 3 / P54753* / EPH receptor B3*ENSMUSG0000000595846
Ephb2 / P54763 / Ephrin type-B receptor 2 / P29323* / EPH receptor B2*ENSMUSG0000002866446
Ephb4 / P54761 / Ephrin type-B receptor 4 / P54760* / EPH receptor B4*ENSMUSG0000002971042
Epha4 / Q03137 / Ephrin type-A receptor 4 / P54764* / EPH receptor A4*ENSMUSG0000002623542
Epha7 / Q61772 / Ephrin type-A receptor 7 / Q15375* / EPH receptor A7*ENSMUSG0000002828941
Epha6 / EPH receptor A6 / Q9UF33*ENSMUSG0000005554040
Epha8 / O09127 / Ephrin type-A receptor 8 / P29322* / EPH receptor A8*ENSMUSG0000002866139
Epha3 / EPH receptor A3 / P29320*ENSMUSG0000005250439
Epha2 / Q03145 / Ephrin type-A receptor 2 ENSMUSG0000000644536
Epha1 / Q60750 / Ephrin type-A receptor 1 / P21709* / EPH receptor A1*ENSMUSG0000002985935
Epha5 / Q60629 / Ephrin type-A receptor 5 / P54756* / EPH receptor A5*ENSMUSG0000002924534


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001090  Ephrin receptor ligand binding domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR001426  Tyrosine-protein kinase, receptor class V, conserved site
 IPR001660  Sterile alpha motif domain
 IPR003961  Fibronectin type III
 IPR008979  Galactose-binding-like domain superfamily
 IPR011009  Protein kinase-like domain superfamily
 IPR011641  Tyrosine-protein kinase ephrin type A/B receptor-like
 IPR013761  Sterile alpha motif/pointed domain superfamily
 IPR013783  Immunoglobulin-like fold
 IPR016257  Ephrin receptor type-A /type-B
 IPR027936  Ephrin receptor, transmembrane domain
 IPR036116  Fibronectin type III superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001806 type IV hypersensitivity IMP
 biological_processGO:0002456 T cell mediated immunity IMP
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IEA
 biological_processGO:0032092 positive regulation of protein binding IMP
 biological_processGO:0048013 ephrin receptor signaling pathway IEA
 biological_processGO:0050663 cytokine secretion IMP
 biological_processGO:0050798 activated T cell proliferation IMP
 biological_processGO:2000525 positive regulation of T cell costimulation IGI
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0005003 ephrin receptor activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005524 ATP binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000242 impaired fertilization "defect or reduced ability in the process beginning with penetration of the secondary oocyte by the spermatozoon and completed by fusion of the male and female pronucei" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Bmpr2tm1Kmi/Bmpr2+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
Show

Allelic Composition: Bmpr2tm1Kmi/Bmpr2+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Inhatm1Bay/Inhatm1Bay,Smad3tm1Par/Smad3+
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBr * 129X1/Sv * C57BL/6

Allelic Composition: Ephb6tm2Tom/Ephb6tm2Tom
Genetic Background: involves: 129S4/SvJae * ICR

 MP:0002675 asthenozoospermia "loss or reduction of the mobility of the spermatozoa, frequently associated with infertility" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Bmpr2tm1Kmi/Bmpr2+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0003009 abnormal cytokine secretion "impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]
Show

Allelic Composition: Apctm2.1Cip/Apctm2.1Cip
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

 MP:0004800 decreased susceptibility to experimental autoimmune encephalomyelitis "reduced likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Apctm2.1Cip/Apctm2.1Cip
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

 MP:0004933 abnormal epididymis epithelium morphology "any structural anomaly of the layer of secretory cells which lines the epididymis" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bmpr2tm1Kmi/Bmpr2+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Apctm2.1Cip/Apctm2.1Cip
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

 MP:0005616 decreased susceptibility to type IV hypersensitivity reaction "less likelihood of or resistance to developing an antigen-elicited cellular immune reaction that results in tissue damage, but does not require Ab participation; the response is seen at the area of contact" [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Apctm2.1Cip/Apctm2.1Cip
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

 MP:0009325 necrospermia "condition in which spermatozoa in seminal fluid are dead or motionless" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bmpr2tm1Kmi/Bmpr2+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0009647 decreased fertilization frequency "he number of secondary oocytes each penetrated by a spermatozoon followed by fusion of the male and female pronuclei are fewer than expected" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bmpr2tm1Kmi/Bmpr2+
Genetic Background: involves: 129S4/SvJae * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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