ENSG00000131236


Homo sapiens

Features
Gene ID: ENSG00000131236
  
Biological name :CAP1
  
Synonyms : CAP1 / cyclase associated actin cytoskeleton regulatory protein 1 / Q01518
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: p34.2
Gene start: 40040233
Gene end: 40072649
  
Corresponding Affymetrix probe sets: 200625_s_at (Human Genome U133 Plus 2.0 Array)   213798_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000413656
Ensembl peptide - ENSP00000344832
Ensembl peptide - ENSP00000412859
Ensembl peptide - ENSP00000413383
Ensembl peptide - ENSP00000361878
Ensembl peptide - ENSP00000361883
Ensembl peptide - ENSP00000361884
Ensembl peptide - ENSP00000361888
Ensembl peptide - ENSP00000361891
Ensembl peptide - ENSP00000389974
Ensembl peptide - ENSP00000398475
Ensembl peptide - ENSP00000398877
Ensembl peptide - ENSP00000400943
Ensembl peptide - ENSP00000403198
Ensembl peptide - ENSP00000408561
Ensembl peptide - ENSP00000410586
NCBI entrez gene - 10487     See in Manteia.
OMIM - 617801
RefSeq - XM_017000073
RefSeq - NM_001105530
RefSeq - NM_006367
RefSeq - XM_011540509
RefSeq - XM_011540510
RefSeq - XM_011540511
RefSeq - XM_011540512
RefSeq - XM_011540513
RefSeq - XM_011540514
RefSeq - XM_011540515
RefSeq - XM_017000067
RefSeq - XM_017000068
RefSeq - XM_017000069
RefSeq - XM_017000070
RefSeq - XM_017000071
RefSeq - XM_017000072
RefSeq - XM_005270368
RefSeq Peptide - NP_006358
RefSeq Peptide - NP_001099000
swissprot - Q5T0R1
swissprot - Q5T0R2
swissprot - Q5T0R3
swissprot - Q5T0R4
swissprot - Q5T0R5
swissprot - Q5T0R6
swissprot - Q5T0R7
swissprot - Q5T0R8
swissprot - Q5T0R9
swissprot - Q5T0S3
swissprot - Q01518
Ensembl - ENSG00000131236
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cap1ENSDARG00000016350Danio rerio
 CAP1ENSGALG00000036294Gallus gallus
 Cap1ENSMUSG00000028656Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CAP2 / P40123 / cyclase associated actin cytoskeleton regulatory protein 2ENSG0000011218663


Protein motifs (from Interpro)
Interpro ID Name
 IPR001837  Adenylate cyclase-associated CAP
 IPR006599  CARP motif
 IPR013912  Adenylate cyclase-associated CAP, C-terminal
 IPR013992  Adenylate cyclase-associated CAP, N-terminal
 IPR017901  C-CAP/cofactor C-like domain
 IPR018106  CAP, conserved site, N-terminal
 IPR028415  Adenylyl cyclase-associated protein CAP1
 IPR028417  CAP, conserved site, C-terminal
 IPR036222  Adenylate cyclase-associated CAP, N-terminal domain superfamily
 IPR036223  Adenylate cyclase-associated CAP, C-terminal superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000902 cell morphogenesis IBA
 biological_processGO:0001667 ameboidal-type cell migration IEA
 biological_processGO:0006898 receptor-mediated endocytosis IEA
 biological_processGO:0007010 cytoskeleton organization IEA
 biological_processGO:0007163 establishment or maintenance of cell polarity TAS
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007190 activation of adenylate cyclase activity TAS
 biological_processGO:0008154 actin polymerization or depolymerization IBA
 biological_processGO:0030036 actin cytoskeleton organization IEA
 biological_processGO:0043312 neutrophil degranulation TAS
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005925 focal adhesion HDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030864 cortical actin cytoskeleton IBA
 cellular_componentGO:0035578 azurophil granule lumen TAS
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0008179 adenylate cyclase binding IBA


Pathways (from Reactome)
Pathway description
Platelet degranulation
Role of ABL in ROBO-SLIT signaling
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000143322 ABL2 / P42684 / ABL proto-oncogene 2, non-receptor tyrosine kinase  / complex / reaction
 ENSG00000145147 SLIT2 / O94813 / slit guidance ligand 2  / complex / reaction
 ENSG00000097007 ABL1 / P00519 / ABL proto-oncogene 1, non-receptor tyrosine kinase  / reaction / complex
 ENSG00000169855 ROBO1 / Q9Y6N7 / roundabout guidance receptor 1  / reaction / complex






 

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