ENSG00000074054


Homo sapiens

Features
Gene ID: ENSG00000074054
  
Biological name :CLASP1
  
Synonyms : CLASP1 / cytoplasmic linker associated protein 1 / Q7Z460
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: -1
Band: q14.3
Gene start: 121337776
Gene end: 121649587
  
Corresponding Affymetrix probe sets: 212752_at (Human Genome U133 Plus 2.0 Array)   240757_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000402101
Ensembl peptide - ENSP00000400562
Ensembl peptide - ENSP00000441625
Ensembl peptide - ENSP00000496269
Ensembl peptide - ENSP00000263710
Ensembl peptide - ENSP00000380717
Ensembl peptide - ENSP00000386442
Ensembl peptide - ENSP00000389372
Ensembl peptide - ENSP00000392886
NCBI entrez gene - 23332     See in Manteia.
OMIM - 605852
RefSeq - XM_017003689
RefSeq - XM_017003680
RefSeq - XM_017003681
RefSeq - XM_017003682
RefSeq - XM_017003683
RefSeq - XM_017003684
RefSeq - XM_017003685
RefSeq - XM_017003686
RefSeq - XM_017003687
RefSeq - XM_017003688
RefSeq - NM_001142273
RefSeq - NM_001142274
RefSeq - NM_001207051
RefSeq - NM_015282
RefSeq - XM_006712377
RefSeq - XM_006712381
RefSeq - XM_006712382
RefSeq - XM_006712383
RefSeq - XM_006712385
RefSeq - XM_011510848
RefSeq - XM_011510849
RefSeq - XM_017003657
RefSeq - XM_017003658
RefSeq - XM_017003659
RefSeq - XM_017003660
RefSeq - XM_017003661
RefSeq - XM_017003662
RefSeq - XM_017003663
RefSeq - XM_017003664
RefSeq - XM_017003665
RefSeq - XM_017003666
RefSeq - XM_017003667
RefSeq - XM_017003668
RefSeq - XM_017003669
RefSeq - XM_017003670
RefSeq - XM_017003671
RefSeq - XM_017003672
RefSeq - XM_017003673
RefSeq - XM_017003674
RefSeq - XM_017003675
RefSeq - XM_017003676
RefSeq - XM_017003677
RefSeq - XM_017003678
RefSeq - XM_017003679
RefSeq Peptide - NP_001135746
RefSeq Peptide - NP_001193980
RefSeq Peptide - NP_056097
RefSeq Peptide - NP_001135745
swissprot - C9JP76
swissprot - Q7Z460
swissprot - F8WA11
swissprot - H0Y5T1
swissprot - C9J151
Ensembl - ENSG00000074054
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 clasp1aENSDARG00000010280Danio rerio
 CLASP1ENSGALG00000011645Gallus gallus
 Clasp1ENSMUSG00000064302Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CLASP2 / O75122 / cytoplasmic linker associated protein 2ENSG0000016353959


Protein motifs (from Interpro)
Interpro ID Name
 IPR011989  Armadillo-like helical
 IPR016024  Armadillo-type fold
 IPR021133  HEAT, type 2
 IPR024395  CLASP N-terminal domain
 IPR028399  CLIP-associating protein 1
 IPR034085  TOG domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000086 G2/M transition of mitotic cell cycle TAS
 biological_processGO:0000226 microtubule cytoskeleton organization IMP
 biological_processGO:0001578 microtubule bundle formation IMP
 biological_processGO:0006903 vesicle targeting IMP
 biological_processGO:0007020 microtubule nucleation IMP
 biological_processGO:0007026 negative regulation of microtubule depolymerization IMP
 biological_processGO:0007030 Golgi organization IMP
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007052 mitotic spindle organization IMP
 biological_processGO:0007062 sister chromatid cohesion TAS
 biological_processGO:0007163 establishment or maintenance of cell polarity NAS
 biological_processGO:0010389 regulation of G2/M transition of mitotic cell cycle TAS
 biological_processGO:0010458 exit from mitosis IMP
 biological_processGO:0010470 regulation of gastrulation IMP
 biological_processGO:0010634 positive regulation of epithelial cell migration IMP
 biological_processGO:0010717 regulation of epithelial to mesenchymal transition IMP
 biological_processGO:0030953 astral microtubule organization IMP
 biological_processGO:0031023 microtubule organizing center organization IMP
 biological_processGO:0031111 negative regulation of microtubule polymerization or depolymerization IMP
 biological_processGO:0031116 positive regulation of microtubule polymerization ISS
 biological_processGO:0034453 microtubule anchoring IMP
 biological_processGO:0040001 establishment of mitotic spindle localization IMP
 biological_processGO:0045921 positive regulation of exocytosis IMP
 biological_processGO:0051294 establishment of spindle orientation IMP
 biological_processGO:0051301 cell division IDA
 biological_processGO:0051497 negative regulation of stress fiber assembly IMP
 biological_processGO:0051893 regulation of focal adhesion assembly IMP
 biological_processGO:0070507 regulation of microtubule cytoskeleton organization IGI
 biological_processGO:0090091 positive regulation of extracellular matrix disassembly IMP
 biological_processGO:0090162 establishment of epithelial cell polarity ISS
 biological_processGO:0090307 mitotic spindle assembly ISS
 biological_processGO:0097711 ciliary basal body-plasma membrane docking TAS
 biological_processGO:1903690 negative regulation of wound healing, spreading of epidermal cells IMP
 biological_processGO:1904261 positive regulation of basement membrane assembly involved in embryonic body morphogenesis IMP
 cellular_componentGO:0000775 chromosome, centromeric region IEA
 cellular_componentGO:0000776 kinetochore IEA
 cellular_componentGO:0000777 condensed chromosome kinetochore IEA
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005813 centrosome IDA
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005819 spindle IEA
 cellular_componentGO:0005828 kinetochore microtubule TAS
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005874 microtubule IEA
 cellular_componentGO:0005876 spindle microtubule IDA
 cellular_componentGO:0005881 cytoplasmic microtubule IDA
 cellular_componentGO:0005925 focal adhesion IDA
 cellular_componentGO:0005938 cell cortex IDA
 cellular_componentGO:0016020 membrane HDA
 cellular_componentGO:0030981 cortical microtubule cytoskeleton IDA
 cellular_componentGO:0031592 centrosomal corona IDA
 cellular_componentGO:0035371 microtubule plus-end ISS
 cellular_componentGO:0045180 basal cortex IDA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0002162 dystroglycan binding IPI
 molecular_functionGO:0005488 binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008017 microtubule binding IMP
 molecular_functionGO:0043515 kinetochore binding IMP
 molecular_functionGO:0051010 microtubule plus-end binding IDA


Pathways (from Reactome)
Pathway description
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
Regulation of PLK1 Activity at G2/M Transition
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization from the centrosome
Recruitment of NuMA to mitotic centrosomes
Role of ABL in ROBO-SLIT signaling
Anchoring of the basal body to the plasma membrane
RHO GTPases Activate Formins
Mitotic Prometaphase
AURKA Activation by TPX2


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000097007 ABL1 / P00519 / ABL proto-oncogene 1, non-receptor tyrosine kinase  / complex / reaction
 ENSG00000145147 SLIT2 / O94813 / slit guidance ligand 2  / reaction / complex
 ENSG00000143322 ABL2 / P42684 / ABL proto-oncogene 2, non-receptor tyrosine kinase  / reaction / complex
 ENSG00000169855 ROBO1 / Q9Y6N7 / roundabout guidance receptor 1  / complex / reaction






 

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