ENSG00000163539


Homo sapiens

Features
Gene ID: ENSG00000163539
  
Biological name :CLASP2
  
Synonyms : CLASP2 / cytoplasmic linker associated protein 2 / O75122
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: -1
Band: p22.3
Gene start: 33496245
Gene end: 33718356
  
Corresponding Affymetrix probe sets: 1555469_a_at (Human Genome U133 Plus 2.0 Array)   1558759_s_at (Human Genome U133 Plus 2.0 Array)   212306_at (Human Genome U133 Plus 2.0 Array)   212308_at (Human Genome U133 Plus 2.0 Array)   212309_at (Human Genome U133 Plus 2.0 Array)   238048_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000417666
Ensembl peptide - ENSP00000417518
Ensembl peptide - ENSP00000418411
Ensembl peptide - ENSP00000489023
Ensembl peptide - ENSP00000420307
Ensembl peptide - ENSP00000419974
Ensembl peptide - ENSP00000419305
Ensembl peptide - ENSP00000418945
Ensembl peptide - ENSP00000418939
Ensembl peptide - ENSP00000418488
Ensembl peptide - ENSP00000324364
Ensembl peptide - ENSP00000327760
Ensembl peptide - ENSP00000352581
Ensembl peptide - ENSP00000382297
Ensembl peptide - ENSP00000417386
NCBI entrez gene - 23122     See in Manteia.
OMIM - 605853
RefSeq - XM_017005986
RefSeq - XM_017005970
RefSeq - XM_017005971
RefSeq - XM_017005972
RefSeq - XM_017005973
RefSeq - XM_017005974
RefSeq - XM_017005975
RefSeq - XM_017005976
RefSeq - XM_017005977
RefSeq - XM_017005978
RefSeq - XM_017005979
RefSeq - XM_017005980
RefSeq - XM_017005981
RefSeq - XM_017005982
RefSeq - XM_017005983
RefSeq - XM_017005984
RefSeq - XM_017005985
RefSeq - NM_001207044
RefSeq - NM_015097
RefSeq - XM_006713040
RefSeq - XM_006713041
RefSeq - XM_006713042
RefSeq - XM_006713048
RefSeq - XM_006713049
RefSeq - XM_006713050
RefSeq - XM_006713052
RefSeq - XM_006713053
RefSeq - XM_011533515
RefSeq - XM_017005947
RefSeq - XM_017005948
RefSeq - XM_017005949
RefSeq - XM_017005950
RefSeq - XM_017005951
RefSeq - XM_017005952
RefSeq - XM_017005953
RefSeq - XM_017005954
RefSeq - XM_017005955
RefSeq - XM_017005956
RefSeq - XM_017005957
RefSeq - XM_017005958
RefSeq - XM_017005959
RefSeq - XM_017005960
RefSeq - XM_017005961
RefSeq - XM_017005962
RefSeq - XM_017005963
RefSeq - XM_017005964
RefSeq - XM_017005965
RefSeq - XM_017005966
RefSeq - XM_017005967
RefSeq - XM_017005968
RefSeq - XM_017005969
RefSeq Peptide - NP_001193973
RefSeq Peptide - NP_055912
swissprot - E7ENG2
swissprot - E3W994
swissprot - D6RBU8
swissprot - C9J668
swissprot - B3KR06
swissprot - H7C4I5
swissprot - E7EW49
swissprot - H7C4X8
swissprot - H7C5M8
swissprot - J3KR49
swissprot - O75122
swissprot - A0A0U1RQI6
swissprot - H7C4M5
swissprot - E7ERI8
Ensembl - ENSG00000163539
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 clasp2ENSDARG00000020345Danio rerio
 CLASP2ENSGALG00000032647Gallus gallus
 Clasp2ENSMUSG00000033392Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CLASP1 / Q7Z460 / cytoplasmic linker associated protein 1ENSG0000007405470


Protein motifs (from Interpro)
Interpro ID Name
 IPR011989  Armadillo-like helical
 IPR016024  Armadillo-type fold
 IPR021133  HEAT, type 2
 IPR024395  CLASP N-terminal domain
 IPR034085  TOG domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000226 microtubule cytoskeleton organization IMP
 biological_processGO:0006903 vesicle targeting IMP
 biological_processGO:0007020 microtubule nucleation IMP
 biological_processGO:0007026 negative regulation of microtubule depolymerization NAS
 biological_processGO:0007030 Golgi organization IMP
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007052 mitotic spindle organization IMP
 biological_processGO:0007062 sister chromatid cohesion TAS
 biological_processGO:0007163 establishment or maintenance of cell polarity TAS
 biological_processGO:0010458 exit from mitosis IMP
 biological_processGO:0010470 regulation of gastrulation IMP
 biological_processGO:0010634 positive regulation of epithelial cell migration IMP
 biological_processGO:0010717 regulation of epithelial to mesenchymal transition IMP
 biological_processGO:0031023 microtubule organizing center organization IMP
 biological_processGO:0031110 regulation of microtubule polymerization or depolymerization IMP
 biological_processGO:0032886 regulation of microtubule-based process IMP
 biological_processGO:0034453 microtubule anchoring IMP
 biological_processGO:0045921 positive regulation of exocytosis IMP
 biological_processGO:0051301 cell division IEA
 biological_processGO:0051497 negative regulation of stress fiber assembly IMP
 biological_processGO:0051895 negative regulation of focal adhesion assembly IMP
 biological_processGO:0072659 protein localization to plasma membrane IMP
 biological_processGO:0090091 positive regulation of extracellular matrix disassembly IMP
 biological_processGO:1903690 negative regulation of wound healing, spreading of epidermal cells IMP
 biological_processGO:1904261 positive regulation of basement membrane assembly involved in embryonic body morphogenesis IMP
 cellular_componentGO:0000775 chromosome, centromeric region IEA
 cellular_componentGO:0000776 kinetochore IMP
 cellular_componentGO:0000777 condensed chromosome kinetochore IEA
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005737 cytoplasm NAS
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005802 trans-Golgi network IDA
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005819 spindle IEA
 cellular_componentGO:0005828 kinetochore microtubule TAS
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005874 microtubule IEA
 cellular_componentGO:0005881 cytoplasmic microtubule IDA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005925 focal adhesion IDA
 cellular_componentGO:0005938 cell cortex IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031252 cell leading edge IDA
 cellular_componentGO:0032587 ruffle membrane IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0045180 basal cortex IDA
 cellular_componentGO:0072686 mitotic spindle IMP
 molecular_functionGO:0002162 dystroglycan binding IPI
 molecular_functionGO:0005488 binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008017 microtubule binding IDA
 molecular_functionGO:0043515 kinetochore binding IEA
 molecular_functionGO:0051010 microtubule plus-end binding IDA


Pathways (from Reactome)
Pathway description
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
Role of ABL in ROBO-SLIT signaling
RHO GTPases Activate Formins
Mitotic Prometaphase


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000169855 ROBO1 / Q9Y6N7 / roundabout guidance receptor 1  / reaction / complex
 ENSG00000145147 SLIT2 / O94813 / slit guidance ligand 2  / complex / reaction
 ENSG00000097007 ABL1 / P00519 / ABL proto-oncogene 1, non-receptor tyrosine kinase  / reaction / complex
 ENSG00000143322 ABL2 / P42684 / ABL proto-oncogene 2, non-receptor tyrosine kinase  / complex / reaction






 

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