ENSG00000063660


Homo sapiens

Features
Gene ID: ENSG00000063660
  
Biological name :GPC1
  
Synonyms : glypican 1 / GPC1 / P35052
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: 1
Band: q37.3
Gene start: 240435671
Gene end: 240468078
  
Corresponding Affymetrix probe sets: 202755_s_at (Human Genome U133 Plus 2.0 Array)   202756_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000392629
Ensembl peptide - ENSP00000415077
Ensembl peptide - ENSP00000410251
Ensembl peptide - ENSP00000264039
Ensembl peptide - ENSP00000389276
Ensembl peptide - ENSP00000390242
NCBI entrez gene - 2817     See in Manteia.
OMIM - 600395
RefSeq - NM_002081
RefSeq - XM_011510976
RefSeq Peptide - NP_002072
swissprot - C9J4Y6
swissprot - P35052
swissprot - H7C410
swissprot - H7BZE9
swissprot - H7BZL4
swissprot - H7C024
Ensembl - ENSG00000063660
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gpc1aENSDARG00000019341Danio rerio
 gpc1bENSDARG00000090585Danio rerio
 GPC1ENSGALG00000040316Gallus gallus
 Gpc1ENSMUSG00000034220Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
GPC6 / Q9Y625 / glypican 6ENSG0000018309844
GPC4 / O75487 / glypican 4ENSG0000007671642
GPC2 / Q8N158 / glypican 2ENSG0000021342038
GPC5 / P78333 / glypican 5ENSG0000017939925
GPC3 / P51654 / glypican 3ENSG0000014725722


Protein motifs (from Interpro)
Interpro ID Name
 IPR001863  Glypican
 IPR015502  Glypican-1
 IPR019803  Glypican, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001523 retinoid metabolic process TAS
 biological_processGO:0006024 glycosaminoglycan biosynthetic process TAS
 biological_processGO:0006027 glycosaminoglycan catabolic process TAS
 biological_processGO:0007411 axon guidance TAS
 biological_processGO:0009966 regulation of signal transduction IEA
 biological_processGO:0014037 Schwann cell differentiation ISS
 biological_processGO:0030200 heparan sulfate proteoglycan catabolic process IDA
 biological_processGO:0030203 glycosaminoglycan metabolic process TAS
 biological_processGO:0032288 myelin assembly ISS
 biological_processGO:0040037 negative regulation of fibroblast growth factor receptor signaling pathway IEA
 biological_processGO:0050900 leukocyte migration TAS
 biological_processGO:2001016 positive regulation of skeletal muscle cell differentiation IEA
 cellular_componentGO:0005576 extracellular region IDA
 cellular_componentGO:0005615 extracellular space TAS
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005796 Golgi lumen TAS
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031012 extracellular matrix IDA
 cellular_componentGO:0031225 anchored component of membrane IEA
 cellular_componentGO:0043202 lysosomal lumen TAS
 cellular_componentGO:0045121 membrane raft IEA
 cellular_componentGO:0046658 anchored component of plasma membrane IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0005507 copper ion binding IDA
 molecular_functionGO:0017134 fibroblast growth factor binding IEA
 molecular_functionGO:0043236 laminin binding IEA
 molecular_functionGO:0043395 heparan sulfate proteoglycan binding IEA


Pathways (from Reactome)
Pathway description
A tetrasaccharide linker sequence is required for GAG synthesis
HS-GAG biosynthesis
HS-GAG degradation
Cell surface interactions at the vascular wall
Defective B4GALT7 causes EDS, progeroid type
Defective B3GAT3 causes JDSSDHD
Defective EXT2 causes exostoses 2
Defective EXT1 causes exostoses 1, TRPS2 and CHDS
Signaling by ROBO receptors
Defective B3GALT6 causes EDSP2 and SEMDJL1
Retinoid metabolism and transport


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000231924 PSG1 / P11464 / pregnancy specific beta-1-glycoprotein 1  / complex / reaction
 ENSG00000145147 SLIT2 / O94813 / slit guidance ligand 2  / reaction / complex






 

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contact: otassy@igbmc.fr