ENSG00000179399


Homo sapiens

Features
Gene ID: ENSG00000179399
  
Biological name :GPC5
  
Synonyms : glypican 5 / GPC5 / P78333
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 13
Strand: 1
Band: q31.3
Gene start: 91398607
Gene end: 92873682
  
Corresponding Affymetrix probe sets: 207174_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000366267
Ensembl peptide - ENSP00000480819
Ensembl peptide - ENSP00000480653
NCBI entrez gene - 2262     See in Manteia.
OMIM - 602446
RefSeq - XM_011521054
RefSeq - XM_017020437
RefSeq - NM_004466
RefSeq - XM_017020435
RefSeq Peptide - NP_004457
swissprot - P78333
swissprot - A0A087WX91
swissprot - A0A087WX13
Ensembl - ENSG00000179399
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gpc5aENSDARG00000103647Danio rerio
 GPC5ENSGALG00000016902Gallus gallus
 Gpc5ENSMUSG00000022112Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
GPC3 / P51654 / glypican 3ENSG0000014725741
GPC6 / Q9Y625 / glypican 6ENSG0000018309824
GPC4 / O75487 / glypican 4ENSG0000007671624
GPC1 / P35052 / glypican 1ENSG0000006366024
GPC2 / Q8N158 / glypican 2ENSG0000021342023


Protein motifs (from Interpro)
Interpro ID Name
 IPR001863  Glypican
 IPR019803  Glypican, conserved site
 IPR031188  Glypican-5


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001523 retinoid metabolic process TAS
 biological_processGO:0006024 glycosaminoglycan biosynthetic process TAS
 biological_processGO:0006027 glycosaminoglycan catabolic process TAS
 biological_processGO:0009966 regulation of signal transduction IEA
 biological_processGO:0030203 glycosaminoglycan metabolic process TAS
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005796 Golgi lumen TAS
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031225 anchored component of membrane IEA
 cellular_componentGO:0043202 lysosomal lumen TAS
 cellular_componentGO:0046658 anchored component of plasma membrane IEA
 molecular_functionGO:0043395 heparan sulfate proteoglycan binding IEA


Pathways (from Reactome)
Pathway description
A tetrasaccharide linker sequence is required for GAG synthesis
HS-GAG biosynthesis
HS-GAG degradation
Defective B4GALT7 causes EDS, progeroid type
Defective B3GAT3 causes JDSSDHD
Defective EXT2 causes exostoses 2
Defective EXT1 causes exostoses 1, TRPS2 and CHDS
Defective B3GALT6 causes EDSP2 and SEMDJL1
Release of Hh-Np from the secreting cell
Retinoid metabolism and transport


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000164690 SHH / Q15465 / sonic hedgehog  / complex / reaction
 ENSG00000185269 NOTUM / Q6P988 / notum, palmitoleoyl-protein carboxylesterase  / reaction






 

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