ENSG00000185269


Homo sapiens

Features
Gene ID: ENSG00000185269
  
Biological name :NOTUM
  
Synonyms : NOTUM / notum, palmitoleoyl-protein carboxylesterase / Q6P988
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: -1
Band: q25.3
Gene start: 81952507
Gene end: 81961840
  
Corresponding Affymetrix probe sets: 228649_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000387310
Ensembl peptide - ENSP00000464734
Ensembl peptide - ENSP00000407905
NCBI entrez gene - 147111     See in Manteia.
OMIM - 609847
RefSeq - NM_178493
RefSeq Peptide - NP_848588
swissprot - C9JYG8
swissprot - K7EIG3
swissprot - Q6P988
Ensembl - ENSG00000185269
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 C5H5C4ENSDARG00000031126Danio rerio
 notum1bENSDARG00000117145Danio rerio
 NOTUMENSGALG00000002900Gallus gallus
 NotumENSMUSG00000042988Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR004963  Pectinacetylesterase/NOTUM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0030178 negative regulation of Wnt signaling pathway IEA
 biological_processGO:0043687 post-translational protein modification TAS
 biological_processGO:0044267 cellular protein metabolic process TAS
 biological_processGO:0090090 negative regulation of canonical Wnt signaling pathway IBA
 biological_processGO:1990697 protein depalmitoleylation IDA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005788 endoplasmic reticulum lumen TAS
 molecular_functionGO:0004629 phospholipase C activity TAS
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0052689 carboxylic ester hydrolase activity IEA
 molecular_functionGO:1990699 palmitoleyl hydrolase activity IDA


Pathways (from Reactome)
Pathway description
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Release of Hh-Np from the secreting cell
Post-translational protein phosphorylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000179399 GPC5 / P78333 / glypican 5  / reaction
 ENSG00000164690 SHH / Q15465 / sonic hedgehog  / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr