ENSMUSG00000042988


Mus musculus

Features
Gene ID: ENSMUSG00000042988
  
Biological name :Notum
  
Synonyms : Notum / Palmitoleoyl-protein carboxylesterase NOTUM / Q8R116
  
Possible biological names infered from orthology : notum, palmitoleoyl-protein carboxylesterase / Q6P988
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: E2
Gene start: 120653788
Gene end: 120661175
  
Corresponding Affymetrix probe sets: 10393904 (MoGene1.0st)   1451857_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000101783
Ensembl peptide - ENSMUSP00000101784
Ensembl peptide - ENSMUSP00000122788
NCBI entrez gene - 77583     See in Manteia.
MGI - MGI:1924833
RefSeq - XM_011249315
RefSeq - NM_175263
RefSeq - XM_006534494
RefSeq - XM_006534497
RefSeq - XM_011249314
RefSeq Peptide - NP_780472
swissprot - Q8R116
swissprot - B7ZCA6
Ensembl - ENSMUSG00000042988
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 C5H5C4ENSDARG00000031126Danio rerio
 notum1bENSDARG00000117145Danio rerio
 NOTUMENSGALG00000002900Gallus gallus
 NOTUMENSG00000185269Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR004963  Pectinacetylesterase/NOTUM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0030178 negative regulation of Wnt signaling pathway IDA
 biological_processGO:0090090 negative regulation of canonical Wnt signaling pathway IBA
 biological_processGO:1990697 protein depalmitoleylation ISO
 cellular_componentGO:0005575 cellular_component ND
 cellular_componentGO:0005576 extracellular region IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0052689 carboxylic ester hydrolase activity IEA
 molecular_functionGO:1990699 palmitoleyl hydrolase activity ISO


Pathways (from Reactome)
Pathway description
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Release of Hh-Np from the secreting cell
Post-translational protein phosphorylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000002633 Shh / Q62226 / Sonic hedgehog protein Sonic hedgehog protein N-product / Q15465* / sonic hedgehog*  / reaction
 ENSMUSG00000022112 Gpc5 / Q8CAL5 / glypican 5 / P78333*  / reaction






 

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