ENSMUSG00000022112


Mus musculus

Features
Gene ID: ENSMUSG00000022112
  
Biological name :Gpc5
  
Synonyms : glypican 5 / Gpc5 / Q8CAL5
  
Possible biological names infered from orthology : P78333
  
Species: Mus musculus
  
Chr. number: 14
Strand: 1
Band: E4
Gene start: 115092215
Gene end: 116525179
  
Corresponding Affymetrix probe sets: 10416960 (MoGene1.0st)   1457536_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000022707
Ensembl peptide - ENSMUSP00000135085
Ensembl peptide - ENSMUSP00000135857
NCBI entrez gene - 103978     See in Manteia.
MGI - MGI:1194894
RefSeq - XM_017315745
RefSeq - XM_006518321
RefSeq - XM_006518322
RefSeq - XM_011244875
RefSeq - XM_011244876
RefSeq - NM_175500
RefSeq - XM_006518320
RefSeq Peptide - NP_780709
swissprot - H3BLN8
swissprot - H3BJQ8
swissprot - Q8CAL5
Ensembl - ENSMUSG00000022112
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gpc5aENSDARG00000103647Danio rerio
 GPC5ENSGALG00000016902Gallus gallus
 GPC5ENSG00000179399Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gpc3 / Q8CFZ4 / glypican 3 / P51654*ENSMUSG0000005565341
Gpc1 / Q9QZF2 / glypican 1 / P35052*ENSMUSG0000003422025
Gpc2 / Q8BKV1 / glypican 2 (cerebroglycan) / Q8N158* / glypican 2*ENSMUSG0000002951023
Gpc4 / P51655 / glypican 4 / O75487*ENSMUSG0000003111923
Gpc6 / Q9R087 / glypican 6 / Q9Y625*ENSMUSG0000005857123
Gm43720 / GPC2* / Q8N158* / glypican 2*ENSMUSG0000010624710


Protein motifs (from Interpro)
Interpro ID Name
 IPR001863  Glypican
 IPR019803  Glypican, conserved site
 IPR031188  Glypican-5


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0009966 regulation of signal transduction IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005796 Golgi lumen TAS
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031225 anchored component of membrane IEA
 cellular_componentGO:0046658 anchored component of plasma membrane IEA
 molecular_functionGO:0043395 heparan sulfate proteoglycan binding IEA


Pathways (from Reactome)
Pathway description
A tetrasaccharide linker sequence is required for GAG synthesis
HS-GAG biosynthesis
HS-GAG degradation
Release of Hh-Np from the secreting cell
Retinoid metabolism and transport


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000150 abnormal rib morphology "malformed bones forming the bony wall of the chest" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:50311]
Show

Allelic Composition: Srrm4tm1e(EUCOMM)Wtsi/Srrm4tm1e(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Srrm4tm1e(EUCOMM)Wtsi/Wtsi

 MP:0000198 hypophosphatemia "abnormally low concentrations of phosphates in the circulating blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Srrm4tm1e(EUCOMM)Wtsi/Srrm4tm1e(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Srrm4tm1e(EUCOMM)Wtsi/Wtsi

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000002633 Shh / Q62226 / Sonic hedgehog protein Sonic hedgehog protein N-product / Q15465* / sonic hedgehog*  / complex / reaction
 ENSMUSG00000042988 Notum / Q8R116 / Palmitoleoyl-protein carboxylesterase NOTUM / Q6P988* / notum, palmitoleoyl-protein carboxylesterase*  / reaction






 

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