Manteia

ID	Phenotype	Definition	Genetic BG
MP:0000087	absent mandible	"missing the lower bony framework of the mouth where the inferior teeth are held" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Gpc3^tm1Arge/Y Genetic Background: either: (involves: 129S/SvEv * 129S1/Sv) or (involves: 129S1/Sv * C57BL/6J)
MP:0000150	abnormal rib morphology	"malformed bones forming the bony wall of the chest" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:50311]	Show Allelic Composition: Gpc3^Gt(Ex136)Byg/Gpc3⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Bmp4^tm1Blh/Bmp4⁺,Gpc3^tm1Snd/Y Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6
MP:0000154	rib fusion	"appearance of one or more ribs as a single structure" [J:62022, J:62023]	Show Allelic Composition: Gpc3^tm1Arge/Y,H19^tm1Tilg/H19⁺ Genetic Background: involves: 129S/SvEv * 129S1/Sv Allelic Composition: Bmp4^tm1Blh/Bmp4⁺,Gpc3^Gt(Ex136)Byg/Y Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 Allelic Composition: Bmp4^tm1Blh/Bmp4⁺,Gpc3^tm1Snd/Y Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6
MP:0000189	hypoglycemia	"low levels of plasma glucose in the circulating blood; this generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Gpc3^tm1Arge/Y Genetic Background: either: (involves: 129S/SvEv * 129S1/Sv) or (involves: 129S1/Sv * C57BL/6J)
MP:0000284	double outlet right ventricle	"both the aorta and the pulmonary trunk originate from the right ventricle, usually in conjunction with a ventricular septal defect" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:67826]	Show Allelic Composition: Angptl3^tm1Lex/Angptl3^tm1Lex,Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: involves: 129S5/SvEvBrd * 129S7/SvEvBrd * C57BL/6
MP:0000373	belly spot	"the appearance of a round area of white fur on the belly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Rasgrp1^tm1Jstn/Rasgrp1^tm1Jstn,Rasgrp3^tm1Jstn/Rasgrp3^tm1Jstn Genetic Background: involves: 129P3/J * C57BL/6J Allelic Composition: Gpc3^tm1Arge/Y Genetic Background: either: (involves: 129S/SvEv * 129S1/Sv) or (involves: 129S1/Sv * C57BL/6J) Allelic Composition: Gpc3^tm1Arge/Gpc3⁺ Genetic Background: either: (involves: 129S/SvEv * 129S1/Sv) or (involves: 129S1/Sv * C57BL/6J)
MP:0000460	mandible hypoplasia	"arrested growth or atrophy of the lower bony framework of the mouth where the inferior teeth are held" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator, J:54637]	Show Allelic Composition: Cckar^tm1Kym/Cckar^tm1Kym,Cckbr^tm1Tom/Cckbr^tm1Tom Genetic Background: involves: 129S4/SvJae * C57BL/6J Allelic Composition: Gpc3^tm1Fil/Gpc3^tm1Fil Genetic Background: B6.Cg-Gpc3^tm1Fil
MP:0000477	abnormal intestine morphology	"malformation of the digestive tube passing from the stomach to the anus" [J:48968]	Show Allelic Composition: Gpc3^tm1Arge/Gpc3^tm1Arge Genetic Background: either: (involves: 129S/SvEv * 129S1/Sv) or (involves: 129S1/Sv * C57BL/6J)
MP:0000480	increased number of ribs	"greater than normal numbers of the pairs of bony structures that make up the body wall" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]	Show Allelic Composition: Gpc3^tm1Arge/Y,H19^tm1Tilg/H19⁺ Genetic Background: involves: 129S/SvEv * 129S1/Sv
MP:0000519	hydronephrosis	"dilation of the pelvis and calices of one or both kidneys" [J:56641]	Show Allelic Composition: Gpc3^tm1Arge/Y Genetic Background: either: (involves: 129S/SvEv * 129S1/Sv) or (involves: 129S1/Sv * C57BL/6J)
MP:0000521	abnormal kidney cortex	"anomalous structure or development of the outer area of the kidney, which contains the glomerular capillaries and the capsula glomeruli that enclose it " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Cckar^tm1Kym/Cckar^tm1Kym,Cckbr^tm1Tom/Cckbr^tm1Tom Genetic Background: involves: 129S4/SvJae * C57BL/6J
MP:0000522	cysts in kidney cortex	"abnormal membranous sacs appearing in the renal lobules, tubules and glomeruli" [J:50844]	Show Allelic Composition: Gpc3^tm1Arge/Y Genetic Background: either: (involves: 129S/SvEv * 129S1/Sv) or (involves: 129S1/Sv * C57BL/6J)
MP:0000527	abnormal kidney development	"anomalous differentiation of the paired organs responsible for urine secretion" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Cckar^tm1Kym/Cckar^tm1Kym,Cckbr^tm1Tom/Cckbr^tm1Tom Genetic Background: involves: 129S4/SvJae * C57BL/6J Allelic Composition: Gpc3^tm1Fil/Gpc3⁺ Genetic Background: B6.Cg-Gpc3^tm1Fil Allelic Composition: Gpc3^tm1Fil/Gpc3^tm1Fil Genetic Background: B6.Cg-Gpc3^tm1Fil
MP:0000556	abnormal hindlimb morphology	"malformation of the entire posterior extremities" [MGI:tc]	Show Allelic Composition: Gpc3^tm1Arge/Gpc3^tm1Arge,H19^tm1Tilg/H19⁺ Genetic Background: involves: 129S/SvEv * 129S1/Sv Allelic Composition: Gpc3^tm1Arge/Gpc3^tm1Arge,Igf1r^tm1Arge/Igf1r^tm1Arge Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6J
MP:0000562	polydactyly	"greater than 5 digits on one or more autopods" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Gpc3^tm1Arge/Y Genetic Background: either: (involves: 129S/SvEv * 129S1/Sv) or (involves: 129S1/Sv * C57BL/6J) Allelic Composition: Bmp4^tm1Blh/Bmp4⁺,Gpc3^Gt(Ex136)Byg/Y Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 Allelic Composition: Bmp4^tm1Blh/Bmp4⁺,Gpc3^tm1Snd/Y Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6
MP:0000692	small spleen	"decreased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Gpc3^tm1Arge/Y Genetic Background: either: (involves: 129S/SvEv * 129S1/Sv) or (involves: 129S1/Sv * C57BL/6J)
MP:0001123	dilated uterus	"stretched or enlarged female muscular organ of gestation" [J:50844]	Show Allelic Composition: Gpc3^tm1Fil/Gpc3^tm1Fil Genetic Background: B6.Cg-Gpc3^tm1Fil
MP:0001144	fused vaginal opening	"condition in which the external vaginal opening is closed by the adherence of the epithelium of the vagina" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Gpc3^tm1Fil/Gpc3^tm1Fil Genetic Background: B6.Cg-Gpc3^tm1Fil
MP:0001260	increased body weight	"greater than normal average weight " [J:33400]	Show Allelic Composition: Cckar^tm1Kym/Cckar^tm1Kym,Cckbr^tm1Tom/Cckbr^tm1Tom Genetic Background: involves: 129S4/SvJae * C57BL/6J Allelic Composition: Gpc3^tm1Fil/Gpc3⁺ Genetic Background: B6.Cg-Gpc3^tm1Fil Allelic Composition: Gpc3^tm1Arge/Y Genetic Background: either: (involves: 129S/SvEv * 129S1/Sv) or (involves: 129S1/Sv * C57BL/6J) Allelic Composition: Gpc3^tm1Arge/Y,H19^tm1Tilg/H19⁺ Genetic Background: involves: 129S/SvEv * 129S1/Sv Allelic Composition: Gpc3^tm1Fil/Gpc3^tm1Fil Genetic Background: B6.Cg-Gpc3^tm1Fil
MP:0001264	increased body size	"larger than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33401]	Show Allelic Composition: Angptl3^tm1Lex/Angptl3^tm1Lex,Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: involves: 129S5/SvEvBrd * 129S7/SvEvBrd * C57BL/6 Allelic Composition: Gpc3^tm1Snd/Gpc3⁺ Genetic Background: involves: 129X1/SvJ * C57BL/6 Allelic Composition: Gpc3^Gt(Ex136)Byg/Y Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Gpc3^Gt(Ex136)Byg/Gpc3⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0001270	distended abdomen	"abdomen appears curved outward or swollen; can be due to skeletal axial defects, enlarged visceral organs or megacolon" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Gpc3^tm1Arge/Gpc3^tm1Arge Genetic Background: either: (involves: 129S/SvEv * 129S1/Sv) or (involves: 129S1/Sv * C57BL/6J)
MP:0001699	enlarged embryo size	"larger proportions of embryo compared to littermates" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]	Show Allelic Composition: Coq7^tm1Hek/Coq7⁺ Genetic Background: B6.129-Coq7^tm1Hek
MP:0001732	postnatal growth retardation	"slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Gpc3^tm1Arge/Y Genetic Background: either: (involves: 129S/SvEv * 129S1/Sv) or (involves: 129S1/Sv * C57BL/6J)
MP:0001861	lung inflammation	"local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Cckar^tm1Kym/Cckar^tm1Kym,Cckbr^tm1Tom/Cckbr^tm1Tom Genetic Background: involves: 129S4/SvJae * C57BL/6J Allelic Composition: Gpc3^tm1Fil/Gpc3^tm1Fil Genetic Background: B6.Cg-Gpc3^tm1Fil
MP:0001867	rhinitis	"inflammation of the mucous membrane of the nose" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]	Show Allelic Composition: Cckar^tm1Kym/Cckar^tm1Kym,Cckbr^tm1Tom/Cckbr^tm1Tom Genetic Background: involves: 129S4/SvJae * C57BL/6J
MP:0002135	abnormal kidney morphology	"abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Gpc3^tm1Arge/Gpc3^tm1Arge Genetic Background: either: (involves: 129S/SvEv * 129S1/Sv) or (involves: 129S1/Sv * C57BL/6J)
MP:0002398	abnormal bone marrow cell morphology/development	"anomalous structure or formation of the cells found in the bone marrow" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Myh9^tm5Rsad/Myh9^tm5Rsad,Tg(Nphs2-cre)1Seq/0 Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ
MP:0002412	increased susceptibility to bacterial infection	"greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Cckar^tm1Kym/Cckar^tm1Kym,Cckbr^tm1Tom/Cckbr^tm1Tom Genetic Background: involves: 129S4/SvJae * C57BL/6J Allelic Composition: Gpc3^tm1Fil/Gpc3^tm1Fil Genetic Background: B6.Cg-Gpc3^tm1Fil
MP:0002705	dilated renal tubules	"enlarged lumens of the loops of Henle and/or collecting ducts of the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Gpc3^tm1Arge/Y Genetic Background: either: (involves: 129S/SvEv * 129S1/Sv) or (involves: 129S1/Sv * C57BL/6J)
MP:0002707	abnormal kidney weight	"anomaly in the heft of the organs responsible for urine secretion" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Cckar^tm1Kym/Cckar^tm1Kym,Cckbr^tm1Tom/Cckbr^tm1Tom Genetic Background: involves: 129S4/SvJae * C57BL/6J
MP:0002938	white spotting	"the appearance of patches of white fur" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Rasgrp1^tm1Jstn/Rasgrp1^tm1Jstn,Rasgrp3^tm1Jstn/Rasgrp3^tm1Jstn Genetic Background: involves: 129P3/J * C57BL/6J Allelic Composition: Gpc3^tm1Arge/Y Genetic Background: either: (involves: 129S/SvEv * 129S1/Sv) or (involves: 129S1/Sv * C57BL/6J) Allelic Composition: Gpc3^tm1Arge/Gpc3⁺ Genetic Background: either: (involves: 129S/SvEv * 129S1/Sv) or (involves: 129S1/Sv * C57BL/6J)
MP:0003014	abnormal kidney medulla morphology	"anomalous structure of the inner portion of the kidney consisting of the renal pyramids" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:88636, smb:Susan M. Bello , Mouse Genome Informatics Curator]	Show Allelic Composition: Cckar^tm1Kym/Cckar^tm1Kym,Cckbr^tm1Tom/Cckbr^tm1Tom Genetic Background: involves: 129S4/SvJae * C57BL/6J Allelic Composition: Gpc3^tm1Arge/Y Genetic Background: either: (involves: 129S/SvEv * 129S1/Sv) or (involves: 129S1/Sv * C57BL/6J) Allelic Composition: Gpc3^tm1Snd/Y Genetic Background: involves: 129X1/SvJ * C57BL/6 Allelic Composition: Gpc3^tm1Snd/Gpc3⁺ Genetic Background: involves: 129X1/SvJ * C57BL/6 Allelic Composition: Gpc3^Gt(Ex136)Byg/Y Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Gpc3^Gt(Ex136)Byg/Gpc3⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0003052	omphalocele	"protrusion of abdominal viscera at the base of the umbilical cord, with a covering membranous sac of peritoneum-amnion" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003, ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator]	Show Allelic Composition: Gpc3^tm1Arge/Y,H19^tm1Tilg/H19⁺ Genetic Background: involves: 129S/SvEv * 129S1/Sv
MP:0003068	enlarged kidney	"larger than average size of the kidney" [J:86005, pvb:Pierre Vanden Borre, Mouse Genome Informatics Curator]	Show Allelic Composition: Cckar^tm1Kym/Cckar^tm1Kym,Cckbr^tm1Tom/Cckbr^tm1Tom Genetic Background: involves: 129S4/SvJae * C57BL/6J
MP:0003122	maternal imprinting	"specific loci are inactivated during oogenesis and are not expressed in offspring" [llw2:Linda Washburn, Mouse Genome Informatics Curator, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]	Show Allelic Composition: Gpc3^tm1Arge/Gpc3⁺,Igf2^tm1Rob/Igf2⁺ Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6J Allelic Composition: Gpc3^tm1Arge/Y,Igf2^tm1Rob/Igf2⁺ Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6J
MP:0003123	paternal imprinting	"specific loci are inactivated during spermatogenesis and are not expressed in offspring " [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator, llw2:Linda Washburn, Mouse Genome Informatics Curator]	Show Allelic Composition: Gpc3^tm1Arge/Y,H19^tm1Tilg/H19⁺ Genetic Background: involves: 129S/SvEv * 129S1/Sv Allelic Composition: Gpc3^tm1Arge/Gpc3^tm1Arge,H19^tm1Tilg/H19⁺ Genetic Background: involves: 129S/SvEv * 129S1/Sv
MP:0003139	patent ductus arteriosus	"failure of the fetal connection between the aorta and pulmonary artery to close within 24 hours after birth" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Gpc3^tm1Snd/Y Genetic Background: involves: 129X1/SvJ * C57BL/6
MP:0003315	abnormal perineum morphology	"malformation in the area between the genital organs and the anus that lies beneath the pelvic diaphragm" [ncbi:Matthew Mailman, NCBI request, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Gpc3^tm1Fil/Gpc3^tm1Fil Genetic Background: B6.Cg-Gpc3^tm1Fil
MP:0003384	abnormal ventral body wall	"malformation in the anterior portion of a human body or the lower surface of an animal body comprised of ectoderm and mesoderm layers that encloses the body cavity" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, monikat:Monika Tomczuk, Mouse Genome Informatics Curator]	Show Allelic Composition: Gpc3^tm1Snd/Y Genetic Background: involves: 129X1/SvJ * C57BL/6 Allelic Composition: Gpc3^tm1Snd/Gpc3⁺ Genetic Background: involves: 129X1/SvJ * C57BL/6 Allelic Composition: Gpc3^Gt(Ex136)Byg/Y Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Gpc3^Gt(Ex136)Byg/Gpc3⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0003675	kidney cysts	"abnormal membranous sacs in any portion of the pair of organs responsible for urine secretion" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Cckar^tm1Kym/Cckar^tm1Kym,Cckbr^tm1Tom/Cckbr^tm1Tom Genetic Background: involves: 129S4/SvJae * C57BL/6J Allelic Composition: Gpc3^tm1Fil/Gpc3⁺ Genetic Background: B6.Cg-Gpc3^tm1Fil Allelic Composition: Gpc3^tm1Arge/Y Genetic Background: either: (involves: 129S/SvEv * 129S1/Sv) or (involves: 129S1/Sv * C57BL/6J) Allelic Composition: Gpc3^tm1Fil/Gpc3^tm1Fil Genetic Background: B6.Cg-Gpc3^tm1Fil Allelic Composition: Gpc3^Gt(Ex136)Byg/Gpc3^Gt(Ex136)Byg Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Gpc3^tm1Snd/Y Genetic Background: involves: 129X1/SvJ * C57BL/6 Allelic Composition: Gpc3^tm1Snd/Gpc3⁺ Genetic Background: involves: 129X1/SvJ * C57BL/6
MP:0003956	abnormal body size	"anomaly in the average body weight, height and/or length of an organism compared to controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Gpc3^tm1Arge/Gpc3⁺,Igf2^tm1Rob/Igf2⁺ Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6J Allelic Composition: Gpc3^tm1Arge/Y,Igf2^tm1Rob/Igf2⁺ Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6J
MP:0004678	split xiphoid process	"the appearance of an abnormal division of the posterior tip of the sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Gpc3^tm1Arge/Y,H19^tm1Tilg/H19⁺ Genetic Background: involves: 129S/SvEv * 129S1/Sv Allelic Composition: Gpc3^tm1Snd/Y Genetic Background: involves: 129X1/SvJ * C57BL/6 Allelic Composition: Gpc3^tm1Snd/Gpc3⁺ Genetic Background: involves: 129X1/SvJ * C57BL/6 Allelic Composition: Gpc3^Gt(Ex136)Byg/Y Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Gpc3^Gt(Ex136)Byg/Gpc3⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0004754	abnormal kidney collecting duct	"any structural anomaly of the duct that drains fluid from the nephron and either allows bodily reabsorbtion of water or allows the fluid to drain to the bladder via the ureter; the collecting duct system also maintains acid-base homeostasis" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cckar^tm1Kym/Cckar^tm1Kym,Cckbr^tm1Tom/Cckbr^tm1Tom Genetic Background: involves: 129S4/SvJae * C57BL/6J
MP:0004810	decreased hematopoietic stem cell number	"reduced cell count of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Myh9^tm5Rsad/Myh9^tm5Rsad,Tg(Nphs2-cre)1Seq/0 Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ
MP:0004920	increased placenta weight	"increase in the weight of the organ of metabolic interchange between fetus and mother" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Rasgrp1^tm1Jstn/Rasgrp1^tm1Jstn,Rasgrp3^tm1Jstn/Rasgrp3^tm1Jstn Genetic Background: involves: 129P3/J * C57BL/6J Allelic Composition: Gpc3^tm1Arge/Y Genetic Background: either: (involves: 129S/SvEv * 129S1/Sv) or (involves: 129S1/Sv * C57BL/6J) Allelic Composition: Gpc3^tm1Arge/Y,H19^tm1Tilg/H19⁺ Genetic Background: involves: 129S/SvEv * 129S1/Sv
MP:0004936	abnormal ureteric bud branching morphogenesis	"partial or complete failure of the ureteric bud to repeatedly divide into lobules during development of the kidney" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Gpc3^tm1Fil/Gpc3⁺ Genetic Background: B6.Cg-Gpc3^tm1Fil Allelic Composition: Gpc3^tm1Fil/Gpc3^tm1Fil Genetic Background: B6.Cg-Gpc3^tm1Fil
MP:0004953	decreased spleen weight	"reduction in the average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Gpc3^tm1Arge/Y Genetic Background: either: (involves: 129S/SvEv * 129S1/Sv) or (involves: 129S1/Sv * C57BL/6J)
MP:0005584	abnormal enzyme/coenzyme activity	"altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Gpc3^tm1Arge/Y Genetic Background: either: (involves: 129S/SvEv * 129S1/Sv) or (involves: 129S1/Sv * C57BL/6J)
MP:0005630	increased lung weight	"greater than the normal state of the physical heaviness of the lung" [RGD:Rat Genome Database submission]	Show Allelic Composition: Cckar^tm1Kym/Cckar^tm1Kym,Cckbr^tm1Tom/Cckbr^tm1Tom Genetic Background: involves: 129S4/SvJae * C57BL/6J
MP:0006032	abnormal ureteric bud morphology	"anomaly in the formation or development of the ureteric bud that with the metanephric mesenchyme gives rise to the kidneys " [smb:Susan M Bello, Mouse Genome Informatics Curator, J:57313:]	Show Allelic Composition: Cckar^tm1Kym/Cckar^tm1Kym,Cckbr^tm1Tom/Cckbr^tm1Tom Genetic Background: involves: 129S4/SvJae * C57BL/6J Allelic Composition: Gpc3^tm1Fil/Gpc3⁺ Genetic Background: B6.Cg-Gpc3^tm1Fil Allelic Composition: Gpc3^tm1Fil/Gpc3^tm1Fil Genetic Background: B6.Cg-Gpc3^tm1Fil
MP:0008146	asymmetric rib-sternum attachment	"loss of bilateral symmetry in rib attachments to the sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Gpc3^tm1Arge/Y Genetic Background: either: (involves: 129S/SvEv * 129S1/Sv) or (involves: 129S1/Sv * C57BL/6J) Allelic Composition: Gpc3^tm1Arge/Y,H19^tm1Tilg/H19⁺ Genetic Background: involves: 129S/SvEv * 129S1/Sv
MP:0008272	abnormal endochondral bone ossification	"anomaly in the process of the formation of bone by the replacement of cartilage tissue with mineralized bone" [GO:0001958]	Show Allelic Composition: Gpc3^tm1Snd/Y Genetic Background: involves: 129X1/SvJ * C57BL/6
MP:0008277	abnormal sternum ossification	"anomaly in the process of the formation of the sternum bone by the replacement of cartilage tissue with mineralized bone" [GO:0001958, MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]	Show Allelic Composition: Gpc3^tm1Arge/Y,H19^tm1Tilg/H19⁺ Genetic Background: involves: 129S/SvEv * 129S1/Sv Allelic Composition: Bmp4^tm1Blh/Bmp4⁺,Gpc3^Gt(Ex136)Byg/Y Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 Allelic Composition: Bmp4^tm1Blh/Bmp4⁺,Gpc3^tm1Snd/Y Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6
MP:0008396	abnormal osteoclast differentiation	"atypical production of or inability to produce bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Gpc3^tm1Snd/Y Genetic Background: involves: 129X1/SvJ * C57BL/6
MP:0008470	abnormal spleen B cell follicle morphology	"any structural anomaly of the area of the white pulp where the affinity maturation of B cells and the generation of memory B cells and plasma cells occur" [PMID:17495967]	Show Allelic Composition: Gpc3^tm1Arge/Y Genetic Background: either: (involves: 129S/SvEv * 129S1/Sv) or (involves: 129S1/Sv * C57BL/6J)
MP:0009728	abnormal calcaneum morphology	"any structural anomaly of the largest quadrangular bone at the back of the tarsus; it forms the heel or hock and articulates with the talus above it" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Gpc3^tm1Arge/Gpc3^tm1Arge,H19^tm1Tilg/H19⁺ Genetic Background: involves: 129S/SvEv * 129S1/Sv Allelic Composition: Gpc3^tm1Arge/Gpc3^tm1Arge,Igf1r^tm1Arge/Igf1r^tm1Arge Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6J
MP:0010146	umbilical hernia	"an outward bulging (protrusion) of the abdominal lining or part of the abdominal organ(s) through the area around the umbilicus; occurs when the muscle through which blood vessels pass to feed the developing fetus fails to completely close" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator", PMID:20333300]	Show Allelic Composition: Gpc3^tm1Snd/Y Genetic Background: involves: 129X1/SvJ * C57BL/6
MP:0010402	ventricular septal defect	"abnormal communications between the two lower chambers of the heart, including such defects in the perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular regions" [MESH:C14.240.400.560.540]	Show Allelic Composition: Gpc3^tm1Snd/Y Genetic Background: involves: 129X1/SvJ * C57BL/6
MP:0010413	complete atrioventricular septal defect	"a type of atrioventricular septal defect in which a single atrioventricular valve annulus, a common atrioventricular valve, and a defect of the inlet ventricular septum are observed; deficiency of the atrioventricular septum also results in the presence of a large primum atrial septal defect" [http://emedicine.medscape.com]	Show Allelic Composition: Gpc3^tm1Snd/Y Genetic Background: involves: 129X1/SvJ * C57BL/6
MP:0010418	perimembraneous ventricular septal defect	"abnormal communications between the two lower chambers of the heart, occurring in the membranous septum with defects in the adjacent muscular portion of the septum; it is generally located in the LV outflow tract just below the aortic valve, associated with pouches or aneurysms of the septal leaflet of the tricuspid valve, which may partially or completely close the defect; an LV-to-RA shunt may also be associated with this defect" [http://emedicine.medscape.com]	Show Allelic Composition: Gpc3^tm1Snd/Y Genetic Background: involves: 129X1/SvJ * C57BL/6
MP:0010419	inlet ventricular septal defect	"abnormal communications between the two lower chambers of the heart, located posterior to the septal leaflet of the tricuspid valve and which are not associated with defects of the atrioventricular valves" [http://emedicine.medscape.com]	Show Allelic Composition: Gpc3^tm1Snd/Y Genetic Background: involves: 129X1/SvJ * C57BL/6
MP:0010476	coronary fistula	"an abnormal communication between the terminus of a coronary artery, bypassing the myocardial capillary bed and entering either a chamber of the heart (coronary-cameral fistula) or any segment of the systemic or pulmonary circulation (coronary arteriovenous fistula)" [http://emedicine.medscape.com]	Show Allelic Composition: Gpc3^tm1Snd/Y Genetic Background: involves: 129X1/SvJ * C57BL/6
MP:0010551	abnormal coronary vessel morphology	"any structural anomaly of any of the arteries or veins that supply blood to the heart or return blood from the heart muscles to the circulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Gpc3^tm1Snd/Y Genetic Background: involves: 129X1/SvJ * C57BL/6
MP:0010607	common atrioventricular valve	"the presence of a single atrioventricular valve instead of both a mitral and tricuspid valve, most commonly due to incomplete or failure of fetal atrioventricular canal septation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Gpc3^tm1Snd/Y Genetic Background: involves: 129X1/SvJ * C57BL/6
MP:0010763	abnormal hematopoietic stem cell physiology	"any functional anomaly or number of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; HSCs give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Myh9^tm5Rsad/Myh9^tm5Rsad,Tg(Nphs2-cre)1Seq/0 Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ
MP:0010981	abnormal branching involved in ureteric bud morphogenesis	"anomaly in the process in which the branching structure of the ureteric bud is generated and organized" [GO:0001658]	Show Allelic Composition: Cckar^tm1Kym/Cckar^tm1Kym,Cckbr^tm1Tom/Cckbr^tm1Tom Genetic Background: involves: 129S4/SvJae * C57BL/6J
MP:0011085	complete postnatal lethality	"premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]	Show Allelic Composition: Cckar^tm1Kym/Cckar^tm1Kym,Cckbr^tm1Tom/Cckbr^tm1Tom Genetic Background: involves: 129S4/SvJae * C57BL/6J Allelic Composition: Gpc3^tm1Arge/Gpc3^tm1Arge,Igf1^tm1Arge/Igf1^tm1Arge Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6J * DBA * MF1 Allelic Composition: Gpc3^tm1Arge/Y,Igf1^tm1Arge/Igf1^tm1Arge Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6J * DBA * MF1
MP:0011086	partial postnatal lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]	Show Allelic Composition: Cckar^tm1Kym/Cckar^tm1Kym,Cckbr^tm1Tom/Cckbr^tm1Tom Genetic Background: involves: 129S4/SvJae * C57BL/6J Allelic Composition: Gpc3^tm1Arge/Gpc3^tm1Arge Genetic Background: either: (involves: 129S/SvEv * 129S1/Sv) or (involves: 129S1/Sv * C57BL/6J) Allelic Composition: Gpc3^tm1Arge/Y Genetic Background: either: (involves: 129S/SvEv * 129S1/Sv) or (involves: 129S1/Sv * C57BL/6J) Allelic Composition: Gpc3^tm1Arge/Y,H19^tm1Tilg/H19⁺ Genetic Background: involves: 129S/SvEv * 129S1/Sv Allelic Composition: Gpc3^tm1Arge/Gpc3^tm1Arge,H19^tm1Tilg/H19⁺ Genetic Background: involves: 129S/SvEv * 129S1/Sv Allelic Composition: Gpc3^tm1Fil/Gpc3^tm1Fil Genetic Background: B6.Cg-Gpc3^tm1Fil
MP:0011087	complete neonatal lethality	"death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]	Show Allelic Composition: Gpc3^Gt(Ex136)Byg/Gpc3^Gt(Ex136)Byg Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0011089	complete perinatal lethality	"death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]	Show Allelic Composition: Gpc3^tm1Arge/Gpc3^tm1Arge,H19^tm1Tilg/H19⁺ Genetic Background: involves: 129S/SvEv * 129S1/Sv Allelic Composition: Gpc3^tm1Arge/Gpc3^tm1Arge,Igf1r^tm1Arge/Igf1r^tm1Arge Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6J
MP:0011090	partial perinatal lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]	Show Allelic Composition: Gpc3^tm1Arge/Y,H19^tm1Tilg/H19⁺ Genetic Background: involves: 129S/SvEv * 129S1/Sv Allelic Composition: Gpc3^tm1Arge/Gpc3^tm1Arge,H19^tm1Tilg/H19⁺ Genetic Background: involves: 129S/SvEv * 129S1/Sv Allelic Composition: Gpc3^tm1Arge/Gpc3^tm1Arge,Igf1^tm1Arge/Igf1^tm1Arge Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6J * DBA * MF1 Allelic Composition: Gpc3^tm1Arge/Y,Igf1^tm1Arge/Igf1^tm1Arge Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6J * DBA * MF1 Allelic Composition: Gpc3^tm1Snd/Y Genetic Background: involves: 129X1/SvJ * C57BL/6 Allelic Composition: Gpc3^Gt(Ex136)Byg/Y Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0011307	kidney medulla cysts	"abnormal membranous sacs appearing in the inner portion of the kidney which consists of the renal pyramids" [MGI:anna]	Show Allelic Composition: Gpc3^tm1Arge/Y Genetic Background: either: (involves: 129S/SvEv * 129S1/Sv) or (involves: 129S1/Sv * C57BL/6J) Allelic Composition: Gpc3^Gt(Ex136)Byg/Y Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Gpc3^Gt(Ex136)Byg/Gpc3⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0011308	kidney corticomedullary cysts	"development of abnormal membranous sacs in the corticomedullary junction of the kidney" [MGI:anna]	Show Allelic Composition: Gpc3^tm1Arge/Y Genetic Background: either: (involves: 129S/SvEv * 129S1/Sv) or (involves: 129S1/Sv * C57BL/6J)
MP:0011423	kidney cortex atrophy	"acquired diminution of the size of the outer portion of the kidney located between the renal capsule and the renal medulla, associated with wasting as from death and reabsorbtion of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes" [MGI:anna]	Show Allelic Composition: Gpc3^tm1Arge/Y Genetic Background: either: (involves: 129S/SvEv * 129S1/Sv) or (involves: 129S1/Sv * C57BL/6J)
MP:0011520	increased placental labyrinth size	"increase in the size of the structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [MGI:csmith]	Show Allelic Composition: Gpc3^tm1Arge/Y Genetic Background: either: (involves: 129S/SvEv * 129S1/Sv) or (involves: 129S1/Sv * C57BL/6J)

External programs and data are copyrighted by and are the property of their respective authors. The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation
		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr

ENSMUSG00000055653