ENSG00000213420


Homo sapiens

Features
Gene ID: ENSG00000213420
  
Biological name :GPC2
  
Synonyms : glypican 2 / GPC2 / Q8N158
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 7
Strand: -1
Band: q22.1
Gene start: 100169606
Gene end: 100177372
  
Corresponding Affymetrix probe sets: 239422_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000488396
Ensembl peptide - ENSP00000292377
NCBI entrez gene - 221914     See in Manteia.
RefSeq - NM_152742
RefSeq Peptide - NP_689955
swissprot - Q8N158
swissprot - A0A0J9YXG7
Ensembl - ENSG00000213420
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gpc2ENSDARG00000104217Danio rerio
 Gm43720ENSMUSG00000106247Mus musculus
 Gpc2ENSMUSG00000029510Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
GPC6 / Q9Y625 / glypican 6ENSG0000018309840
GPC1 / P35052 / glypican 1ENSG0000006366037
GPC4 / O75487 / glypican 4ENSG0000007671637
GPC5 / P78333 / glypican 5ENSG0000017939923
GPC3 / P51654 / glypican 3ENSG0000014725721


Protein motifs (from Interpro)
Interpro ID Name
 IPR001863  Glypican
 IPR019803  Glypican, conserved site
 IPR031181  Glypican-2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001523 retinoid metabolic process TAS
 biological_processGO:0006024 glycosaminoglycan biosynthetic process TAS
 biological_processGO:0006027 glycosaminoglycan catabolic process TAS
 biological_processGO:0007224 smoothened signaling pathway IEA
 biological_processGO:0009966 regulation of signal transduction IEA
 biological_processGO:0030182 neuron differentiation IEA
 biological_processGO:0030203 glycosaminoglycan metabolic process TAS
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005783 endoplasmic reticulum IDA
 cellular_componentGO:0005796 Golgi lumen TAS
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031225 anchored component of membrane IEA
 cellular_componentGO:0043202 lysosomal lumen TAS
 cellular_componentGO:0046658 anchored component of plasma membrane IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0043395 heparan sulfate proteoglycan binding IEA


Pathways (from Reactome)
Pathway description
A tetrasaccharide linker sequence is required for GAG synthesis
HS-GAG biosynthesis
HS-GAG degradation
Defective B4GALT7 causes EDS, progeroid type
Defective B3GAT3 causes JDSSDHD
Defective EXT2 causes exostoses 2
Defective EXT1 causes exostoses 1, TRPS2 and CHDS
Defective B3GALT6 causes EDSP2 and SEMDJL1
Retinoid metabolism and transport


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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