ENSG00000099331


Homo sapiens

Features
Gene ID: ENSG00000099331
  
Biological name :MYO9B
  
Synonyms : MYO9B / myosin IXB / Q13459
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: 1
Band: p13.11
Gene start: 17075781
Gene end: 17214537
  
Corresponding Affymetrix probe sets: 208452_x_at (Human Genome U133 Plus 2.0 Array)   214780_s_at (Human Genome U133 Plus 2.0 Array)   217297_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000470849
Ensembl peptide - ENSP00000471367
Ensembl peptide - ENSP00000471457
Ensembl peptide - ENSP00000472296
Ensembl peptide - ENSP00000472611
Ensembl peptide - ENSP00000472915
Ensembl peptide - ENSP00000472964
Ensembl peptide - ENSP00000380444
Ensembl peptide - ENSP00000469289
Ensembl peptide - ENSP00000469437
NCBI entrez gene - 4650     See in Manteia.
OMIM - 602129
RefSeq - NM_001130065
RefSeq - NM_004145
RefSeq Peptide - NP_001123537
RefSeq Peptide - NP_004136
swissprot - Q13459
swissprot - M0QXP0
swissprot - M0QXX1
swissprot - M0QZY4
swissprot - M0R0P8
swissprot - M0R240
swissprot - M0R2J3
swissprot - M0R300
swissprot - M0R332
Ensembl - ENSG00000099331
  
Related genetic diseases (OMIM): 609753 - {Celiac disease, susceptibility to, 4}, 609753
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 myo9bENSDARG00000077410Danio rerio
 MYO9BENSDARG00000078313Danio rerio
 MYO9BENSGALG00000003717Gallus gallus
 Myo9bENSMUSG00000004677Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MYO9A / B2RTY4 / myosin IXAENSG0000006693347
MYO7B / Q6PIF6 / myosin VIIBENSG0000016999422
MYO7A / Q13402 / myosin VIIAENSG0000013747421
MYO5A / Q9Y4I1 / myosin VAENSG0000019753521
MYO5B / Q9ULV0 / myosin VBENSG0000016730620
MYO5C / Q9NQX4 / myosin VCENSG0000012883320
MYO10 / Q9HD67 / myosin XENSG0000014555520
MYO6 / Q9UM54 / myosin VIENSG0000019658616
AC090227.1ENSG000002669971


Protein motifs (from Interpro)
Interpro ID Name
 IPR000048  IQ motif, EF-hand binding site
 IPR000159  Ras-associating (RA) domain
 IPR000198  Rho GTPase-activating protein domain
 IPR001609  Myosin head, motor domain
 IPR002219  Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
 IPR008936  Rho GTPase activation protein
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR028557  Unconventional myosin-IXb
 IPR029071  Ubiquitin-like domain superfamily
 IPR036023  Class IX myosin, motor domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007018 microtubule-based movement IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007266 Rho protein signal transduction IC
 biological_processGO:0030048 actin filament-based movement TAS
 biological_processGO:0035023 regulation of Rho protein signal transduction IMP
 biological_processGO:0035385 Roundabout signaling pathway IDA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0051056 regulation of small GTPase mediated signal transduction TAS
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005884 actin filament IDA
 cellular_componentGO:0005938 cell cortex IEA
 cellular_componentGO:0015629 actin cytoskeleton TAS
 cellular_componentGO:0016020 membrane HDA
 cellular_componentGO:0016459 myosin complex IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0000146 microfilament motor activity IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003774 motor activity IEA
 molecular_functionGO:0003777 microtubule motor activity IEA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0005096 GTPase activator activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005516 calmodulin binding IEA
 molecular_functionGO:0005524 ATP binding IDA
 molecular_functionGO:0008017 microtubule binding IEA
 molecular_functionGO:0016887 ATPase activity IDA
 molecular_functionGO:0017048 Rho GTPase binding IPI
 molecular_functionGO:0043531 ADP binding IDA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0048495 Roundabout binding IPI


Pathways (from Reactome)
Pathway description
Rho GTPase cycle
Regulation of actin dynamics for phagocytic cup formation
SLIT2:ROBO1 increases RHOA activity


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000145147 SLIT2 / O94813 / slit guidance ligand 2  / complex / reaction
 ENSG00000067560 RHOA / P61586 / ras homolog family member A  / reaction
 ENSG00000169855 ROBO1 / Q9Y6N7 / roundabout guidance receptor 1  / complex / reaction






 

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