ENSG00000145555


Homo sapiens

Features
Gene ID: ENSG00000145555
  
Biological name :MYO10
  
Synonyms : MYO10 / myosin X / Q9HD67
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 5
Strand: -1
Band: p15.1
Gene start: 16661914
Gene end: 16936276
  
Corresponding Affymetrix probe sets: 1554026_a_at (Human Genome U133 Plus 2.0 Array)   201976_s_at (Human Genome U133 Plus 2.0 Array)   216222_s_at (Human Genome U133 Plus 2.0 Array)   236718_at (Human Genome U133 Plus 2.0 Array)   244350_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000421170
Ensembl peptide - ENSP00000426783
Ensembl peptide - ENSP00000426664
Ensembl peptide - ENSP00000425051
Ensembl peptide - ENSP00000421309
Ensembl peptide - ENSP00000421280
Ensembl peptide - ENSP00000274203
NCBI entrez gene - 4651     See in Manteia.
OMIM - 601481
RefSeq - XM_005248306
RefSeq - XM_011514046
RefSeq - XM_006714475
RefSeq - XM_005248307
RefSeq - NM_012334
RefSeq Peptide - NP_036466
swissprot - Q9HD67
swissprot - E9PEW5
swissprot - A0A0A0MQX1
swissprot - D6RGD1
swissprot - E9PCN3
Ensembl - ENSG00000145555
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 myo10ENSDARG00000017004Danio rerio
 MYO10ENSGALG00000036466Gallus gallus
 Myo10ENSMUSG00000022272Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MYO7A / Q13402 / myosin VIIAENSG0000013747428
MYO7B / Q6PIF6 / myosin VIIBENSG0000016999427
MYO9A / B2RTY4 / myosin IXAENSG0000006693322
MYO9B / Q13459 / myosin IXBENSG0000009933120
MYO5A / Q9Y4I1 / myosin VAENSG0000019753519
MYO5B / Q9ULV0 / myosin VBENSG0000016730619
MYO5C / Q9NQX4 / myosin VCENSG0000012883318
MYO6 / Q9UM54 / myosin VIENSG0000019658616
AC090227.1ENSG000002669971


Protein motifs (from Interpro)
Interpro ID Name
 IPR000048  IQ motif, EF-hand binding site
 IPR000159  Ras-associating (RA) domain
 IPR000299  FERM domain
 IPR000857  MyTH4 domain
 IPR001609  Myosin head, motor domain
 IPR001849  Pleckstrin homology domain
 IPR011993  PH-like domain superfamily
 IPR014352  FERM/acyl-CoA-binding protein superfamily
 IPR019748  FERM central domain
 IPR019749  Band 4.1 domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR031971  Unconventional myosin-X, coiled coil domain
 IPR035963  FERM superfamily, second domain
 IPR036124  Class X myosin, motor domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007018 microtubule-based movement IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0008360 regulation of cell shape IMP
 biological_processGO:0022409 positive regulation of cell-cell adhesion IEA
 biological_processGO:0030705 cytoskeleton-dependent intracellular transport ISS
 biological_processGO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis TAS
 biological_processGO:0051489 regulation of filopodium assembly IMP
 cellular_componentGO:0001726 ruffle IEA
 cellular_componentGO:0005730 nucleolus IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0005938 cell cortex IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016459 myosin complex IEA
 cellular_componentGO:0030027 lamellipodium IEA
 cellular_componentGO:0030175 filopodium IEA
 cellular_componentGO:0031527 filopodium membrane IEA
 cellular_componentGO:0032433 filopodium tip ISS
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003774 motor activity IEA
 molecular_functionGO:0003777 microtubule motor activity IEA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005516 calmodulin binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding ISS
 molecular_functionGO:0008017 microtubule binding IEA
 molecular_functionGO:0030507 spectrin binding IDA
 molecular_functionGO:0030898 actin-dependent ATPase activity ISS
 molecular_functionGO:0051015 actin filament binding ISS
 molecular_functionGO:0060002 plus-end directed microfilament motor activity ISS


Pathways (from Reactome)
Pathway description
Regulation of actin dynamics for phagocytic cup formation
Netrin-1 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000187323 DCC / P43146 / DCC netrin 1 receptor  / complex / reaction
 ENSG00000067141 NEO1 / Q92859 / neogenin 1  / complex / reaction
 ENSG00000145555 MYO10 / Q9HD67 / myosin X  / complex
 ENSG00000075624 ACTB / P60709 / actin beta  / reaction / complex
 ENSG00000184009 ACTG1 / P63261 / actin gamma 1  / reaction / complex






 

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