ENSMUSG00000022272


Mus musculus

Features
Gene ID: ENSMUSG00000022272
  
Biological name :Myo10
  
Synonyms : F8VQB6 / Mus musculus myosin X (Myo10), transcript variant 3, mRNA. / Myo10
  
Possible biological names infered from orthology : myosin X / Q9HD67
  
Species: Mus musculus
  
Chr. number: 15
Strand: 1
Band: B1
Gene start: 25622525
Gene end: 25813673
  
Corresponding Affymetrix probe sets: 10423293 (MoGene1.0st)   1422544_at (Mouse Genome 430 2.0 Array)   1450650_at (Mouse Genome 430 2.0 Array)   1450651_at (Mouse Genome 430 2.0 Array)   1454731_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000106087
Ensembl peptide - ENSMUSP00000123057
Ensembl peptide - ENSMUSP00000120817
Ensembl peptide - ENSMUSP00000120566
Ensembl peptide - ENSMUSP00000119367
Ensembl peptide - ENSMUSP00000119200
Ensembl peptide - ENSMUSP00000118744
Ensembl peptide - ENSMUSP00000118280
Ensembl peptide - ENSMUSP00000022882
NCBI entrez gene - 17909     See in Manteia.
MGI - MGI:107716
RefSeq - NM_001353142
RefSeq - NM_019472
RefSeq - XM_006520026
RefSeq - XM_006520024
RefSeq - XM_006520025
RefSeq Peptide - NP_062345
RefSeq Peptide - NP_001340071
swissprot - E9Q5G1
swissprot - F8VQB6
swissprot - D3Z2P4
swissprot - D3Z2E0
swissprot - D3Z0V4
swissprot - D3YZ13
swissprot - D3YXW4
swissprot - D3YXU7
swissprot - F6UVU0
Ensembl - ENSMUSG00000022272
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 myo10ENSDARG00000017004Danio rerio
 MYO10ENSGALG00000036466Gallus gallus
 MYO10ENSG00000145555Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Myo7a / P97479 / Unconventional myosin-VIIa / Q13402* / myosin VIIA*ENSMUSG0000003076127
Myo7b / Q99MZ6 / Unconventional myosin-VIIb / Q6PIF6* / myosin VIIB*ENSMUSG0000002438825
Myo9a / Q8C170 / Unconventional myosin-IXa / B2RTY4* / myosin IXA*ENSMUSG0000003958522
Myo9b / myosin IXB / Q13459*ENSMUSG0000000467720
Myo5a / Q99104 / Unconventional myosin-Va / Q9Y4I1* / myosin VA*ENSMUSG0000003459319
Myo5b / myosin VB / Q9ULV0*ENSMUSG0000002588519
Myo5c / myosin VC / Q9NQX4*ENSMUSG0000003359018
Myo6 / myosin VI / Q9UM54*ENSMUSG0000003357716


Protein motifs (from Interpro)
Interpro ID Name
 IPR000048  IQ motif, EF-hand binding site
 IPR000159  Ras-associating (RA) domain
 IPR000299  FERM domain
 IPR000857  MyTH4 domain
 IPR001609  Myosin head, motor domain
 IPR001849  Pleckstrin homology domain
 IPR011993  PH-like domain superfamily
 IPR014352  FERM/acyl-CoA-binding protein superfamily
 IPR019748  FERM central domain
 IPR019749  Band 4.1 domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR031971  Unconventional myosin-X, coiled coil domain
 IPR035963  FERM superfamily, second domain
 IPR036124  Class X myosin, motor domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007018 microtubule-based movement IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0008360 regulation of cell shape IEA
 biological_processGO:0022409 positive regulation of cell-cell adhesion IGI
 biological_processGO:0030705 cytoskeleton-dependent intracellular transport ISS
 biological_processGO:0048870 cell motility IC
 biological_processGO:0051489 regulation of filopodium assembly IEA
 cellular_componentGO:0001726 ruffle IEA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005938 cell cortex IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016459 myosin complex IEA
 cellular_componentGO:0030027 lamellipodium IEA
 cellular_componentGO:0030175 filopodium IDA
 cellular_componentGO:0031527 filopodium membrane IEA
 cellular_componentGO:0032433 filopodium tip ISS
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043005 neuron projection IDA
 cellular_componentGO:0043025 neuronal cell body IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003774 motor activity ISO
 molecular_functionGO:0003777 microtubule motor activity IEA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005516 calmodulin binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding ISS
 molecular_functionGO:0008017 microtubule binding IEA
 molecular_functionGO:0030507 spectrin binding IEA
 molecular_functionGO:0030898 actin-dependent ATPase activity ISS
 molecular_functionGO:0051015 actin filament binding ISS
 molecular_functionGO:0060002 plus-end directed microfilament motor activity ISS


Pathways (from Reactome)
Pathway description
Regulation of actin dynamics for phagocytic cup formation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000373 belly spot "the appearance of a round area of white fur on the belly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Foxn1tm3(cre)Nrm/Foxn1+,Gt(ROSA)26Sortm1(Tbx1)Rche/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NHsd

Allelic Composition: Myo10m1J/Myo10m1J
Genetic Background: involves: C57BL/6J

Allelic Composition: Myo10tm1a(KOMP)Wtsi/Myo10tm1a(KOMP)Wtsi
Genetic Background: involves: C57BL/6N

Allelic Composition: Myo10tm1d(KOMP)Wtsi/Myo10tm1d(KOMP)Wtsi
Genetic Background: involves: C57BL/6 * C57BL/6N * C57BL/6NJ

 MP:0000480 increased number of ribs "greater than normal numbers of the pairs of bony structures that make up the body wall" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Myo10tm2(KOMP)Wtsi/Myo10tm2(KOMP)Wtsi
Genetic Background: C57BL/6N-Myo10tm2(KOMP)Wtsi/Wtsi

 MP:0000564 syndactyly "any degree of webbing or fusion of the digits, may involve only soft tissues or also can include bone" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Foxn1tm3(cre)Nrm/Foxn1+,Gt(ROSA)26Sortm1(Tbx1)Rche/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NHsd

Allelic Composition: Myo10m1J/Myo10m1J
Genetic Background: involves: C57BL/6J

Allelic Composition: Myo10tm1a(KOMP)Wtsi/Myo10tm1a(KOMP)Wtsi
Genetic Background: involves: C57BL/6N

Allelic Composition: Myo10tm1d(KOMP)Wtsi/Myo10tm1d(KOMP)Wtsi
Genetic Background: involves: C57BL/6 * C57BL/6N * C57BL/6NJ

 MP:0000585 kinked tail "a sharp bend or zig-zag in the tail" [J:61295]
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Allelic Composition: Myo10tm1a(KOMP)Wtsi/Myo10tm1a(KOMP)Wtsi
Genetic Background: involves: C57BL/6N

Allelic Composition: Myo10tm1d(KOMP)Wtsi/Myo10tm1d(KOMP)Wtsi
Genetic Background: involves: C57BL/6 * C57BL/6N * C57BL/6NJ

 MP:0000914 exencephaly "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Myo10m1J/Myo10m1J
Genetic Background: involves: C57BL/6J

Allelic Composition: Myo10tm1a(KOMP)Wtsi/Myo10tm1a(KOMP)Wtsi
Genetic Background: involves: C57BL/6N

Allelic Composition: Myo10tm1d(KOMP)Wtsi/Myo10tm1d(KOMP)Wtsi
Genetic Background: involves: C57BL/6 * C57BL/6N * C57BL/6NJ

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Cxcr4tm2Yzo/Cxcr4tm2Yzo,Tg(Fabp4-cre)1Rev/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Myo10tm1d(KOMP)Wtsi/Myo10tm1d(KOMP)Wtsi
Genetic Background: involves: C57BL/6 * C57BL/6N * C57BL/6NJ

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Foxn1tm3(cre)Nrm/Foxn1+,Gt(ROSA)26Sortm1(Tbx1)Rche/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NHsd

 MP:0001289 persistence of hyaloid capillary system "failure of the degeneration of the transient vascular system of the eye during development" [J:49840]
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Allelic Composition: Foxn1tm3(cre)Nrm/Foxn1+,Gt(ROSA)26Sortm1(Tbx1)Rche/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NHsd

Allelic Composition: Myo10tm2(KOMP)Wtsi/Myo10tm2(KOMP)Wtsi
Genetic Background: C57BL/6N-Myo10tm2(KOMP)Wtsi/Wtsi

Allelic Composition: Myo10m1J/Myo10m1J
Genetic Background: involves: C57BL/6J

Allelic Composition: Myo10tm1a(KOMP)Wtsi/Myo10tm1a(KOMP)Wtsi
Genetic Background: involves: C57BL/6N

Allelic Composition: Myo10tm1d(KOMP)Wtsi/Myo10tm1d(KOMP)Wtsi
Genetic Background: involves: C57BL/6 * C57BL/6N * C57BL/6NJ

 MP:0001293 anophthalmia "congenital absence of all tissues of the eyes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CML, J:71979]
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Allelic Composition: Myo10m1J/Myo10m1J
Genetic Background: involves: C57BL/6J

Allelic Composition: Myo10tm1d(KOMP)Wtsi/Myo10tm1d(KOMP)Wtsi
Genetic Background: involves: C57BL/6 * C57BL/6N * C57BL/6NJ

 MP:0001297 microphthalmia "reduced average size of the eyes" [J:18048]
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Allelic Composition: Myo10m1J/Myo10m1J
Genetic Background: involves: C57BL/6J

Allelic Composition: Myo10tm1d(KOMP)Wtsi/Myo10tm1d(KOMP)Wtsi
Genetic Background: involves: C57BL/6 * C57BL/6N * C57BL/6NJ

 MP:0001307 fused cornea/lens "condition in which the transparent anterior portion of the fibrous coat of the eye is joined to the transparent biconvex cellular refractive structure lying between the iris and vitreous humor of the eye" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Myo10tm2(KOMP)Wtsi/Myo10tm2(KOMP)Wtsi
Genetic Background: C57BL/6N-Myo10tm2(KOMP)Wtsi/Wtsi

 MP:0001312 abnormal cornea morphology "malformation or absence of the transparent anterior portion of the fibrous coat of the eye that serves as the chief refractory structure " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ush1ctm1a(KOMP)Wtsi/Ush1ctm1a(KOMP)Wtsi
Genetic Background: C57BL/6N-Ush1ctm1a(KOMP)Wtsi/Wtsi

 MP:0001314 corneal opacity "complete or partial clouding of the cornea" [jte:Janan T. Eppig , Mouse Genome Informatics, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Foxn1tm3(cre)Nrm/Foxn1+,Gt(ROSA)26Sortm1(Tbx1)Rche/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NHsd

Allelic Composition: Myo10tm2(KOMP)Wtsi/Myo10tm2(KOMP)Wtsi
Genetic Background: C57BL/6N-Myo10tm2(KOMP)Wtsi/Wtsi

 MP:0001325 abnormal retina morphology "structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Myo10tm2(KOMP)Wtsi/Myo10tm2(KOMP)Wtsi
Genetic Background: C57BL/6N-Myo10tm2(KOMP)Wtsi/Wtsi

Allelic Composition: Myo10tm1d(KOMP)Wtsi/Myo10tm1d(KOMP)Wtsi
Genetic Background: involves: C57BL/6 * C57BL/6N * C57BL/6NJ

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Myo10m1J/Myo10m1J
Genetic Background: involves: C57BL/6J

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Myo10m1J/Myo10m1J
Genetic Background: involves: C57BL/6J

 MP:0002075 abnormal coat color "irregular or unusual pigmentation pattern of the hair in relation to control animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ush1ctm1a(KOMP)Wtsi/Ush1ctm1a(KOMP)Wtsi
Genetic Background: C57BL/6N-Ush1ctm1a(KOMP)Wtsi/Wtsi

 MP:0002092 abnormal eye morphology "abnormal development of the eye tissues resulting in morphological abnormality or abnormal structure of the visual system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Foxn1tm3(cre)Nrm/Foxn1+,Gt(ROSA)26Sortm1(Tbx1)Rche/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NHsd

 MP:0002110 abnormal digit morphology "abnormal development of the digits resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ush1ctm1a(KOMP)Wtsi/Ush1ctm1a(KOMP)Wtsi
Genetic Background: C57BL/6N-Ush1ctm1a(KOMP)Wtsi/Wtsi

 MP:0002152 abnormal brain morphology "anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk]
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Allelic Composition: Cxcr4tm2Yzo/Cxcr4tm2Yzo,Tg(Fabp4-cre)1Rev/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002792 abnormal retinal vascularization "malformation or disorganization of the blood vessels supplying the retina" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Myo10tm1d(KOMP)Wtsi/Myo10tm1d(KOMP)Wtsi
Genetic Background: involves: C57BL/6 * C57BL/6N * C57BL/6NJ

 MP:0002834 decreased heart weight "less than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
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Allelic Composition: Myo10tm2(KOMP)Wtsi/Myo10tm2(KOMP)Wtsi
Genetic Background: C57BL/6N-Myo10tm2(KOMP)Wtsi/Wtsi

 MP:0002938 white spotting "the appearance of patches of white fur" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Foxn1tm3(cre)Nrm/Foxn1+,Gt(ROSA)26Sortm1(Tbx1)Rche/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NHsd

Allelic Composition: Myo10m1J/Myo10m1J
Genetic Background: involves: C57BL/6J

Allelic Composition: Myo10tm1a(KOMP)Wtsi/Myo10tm1a(KOMP)Wtsi
Genetic Background: involves: C57BL/6N

Allelic Composition: Myo10tm1d(KOMP)Wtsi/Myo10tm1d(KOMP)Wtsi
Genetic Background: involves: C57BL/6 * C57BL/6N * C57BL/6NJ

 MP:0003104 acrania "complete or partial absence of a skull; usually associated with anencephaly" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, J:33716]
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Allelic Composition: Myo10m1J/Myo10m1J
Genetic Background: involves: C57BL/6J

 MP:0003227 abnormal vascular branching morphogenesis "increase, decrease or anomaly in the process by which new vessels sprout off pre-existing vessels" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93157]
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Allelic Composition: Myo10tm1d(KOMP)Wtsi/Myo10tm1d(KOMP)Wtsi
Genetic Background: involves: C57BL/6 * C57BL/6N * C57BL/6NJ

 MP:0004151 hypoferremia "less than the normal concentration of this metallic element in the blood" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Myo10tm2(KOMP)Wtsi/Myo10tm2(KOMP)Wtsi
Genetic Background: C57BL/6N-Myo10tm2(KOMP)Wtsi/Wtsi

 MP:0005174 abnormal tail pigmentation "anomalous color of the tail in relation to control animals" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Foxn1tm3(cre)Nrm/Foxn1+,Gt(ROSA)26Sortm1(Tbx1)Rche/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NHsd

 MP:0005545 abnormal lens development "aberrant formation of the transparent structure of the eye responsible for focusing light rays" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Myo10m1J/Myo10m1J
Genetic Background: involves: C57BL/6J

 MP:0005554 decreased circulating creatinine level "less than the normal blood concentration of this product of creatine catabolism; abnormal levels indicative of renal dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Myo10tm2(KOMP)Wtsi/Myo10tm2(KOMP)Wtsi
Genetic Background: C57BL/6N-Myo10tm2(KOMP)Wtsi/Wtsi

 MP:0006243 abnormal pupil dilation reaction to light "the pupil fails to constrict fully when exposed to bright light" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Myo10tm2(KOMP)Wtsi/Myo10tm2(KOMP)Wtsi
Genetic Background: C57BL/6N-Myo10tm2(KOMP)Wtsi/Wtsi

 MP:0008730 fused phalanges "anomaly of the long bones of the digits resulting in some or all the bones being joined together" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Foxn1tm3(cre)Nrm/Foxn1+,Gt(ROSA)26Sortm1(Tbx1)Rche/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NHsd

Allelic Composition: Myo10tm2(KOMP)Wtsi/Myo10tm2(KOMP)Wtsi
Genetic Background: C57BL/6N-Myo10tm2(KOMP)Wtsi/Wtsi

 MP:0008770 decreased survivor rate "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Myo10m1J/Myo10m1J
Genetic Background: involves: C57BL/6J

Allelic Composition: Myo10tm1a(KOMP)Wtsi/Myo10tm1a(KOMP)Wtsi
Genetic Background: involves: C57BL/6N

Allelic Composition: Myo10tm1d(KOMP)Wtsi/Myo10tm1d(KOMP)Wtsi
Genetic Background: involves: C57BL/6 * C57BL/6N * C57BL/6NJ

 MP:0008784 craniorachischisis "congenital fissure of the skull and vertebral column" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Myo10m1J/Myo10m1J
Genetic Background: involves: C57BL/6J

 MP:0009264 failure of eyelid fusion "the upper and lower thin folds of skin and muscle that cover the exposed portion of the eye do not fuse together during development" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Myo10m1J/Myo10m1J
Genetic Background: involves: C57BL/6J

 MP:0010714 coloboma of the iris "congenital defect of the iris in which some part of the structure is absent" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Foxn1tm3(cre)Nrm/Foxn1+,Gt(ROSA)26Sortm1(Tbx1)Rche/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NHsd

 MP:0011112 partial lethality during fetal growth through weaning "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and weaning age (Mus: E14 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Myo10m1J/Myo10m1J
Genetic Background: involves: C57BL/6J

Allelic Composition: Myo10tm1a(KOMP)Wtsi/Myo10tm1a(KOMP)Wtsi
Genetic Background: involves: C57BL/6N

Allelic Composition: Myo10tm1d(KOMP)Wtsi/Myo10tm1d(KOMP)Wtsi
Genetic Background: involves: C57BL/6 * C57BL/6N * C57BL/6NJ

 MP:0011277 decreased tail pigmentation "visually detectable dilution of pigment present on the tail surface" [MGI:csmith]
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Allelic Composition: Foxn1tm3(cre)Nrm/Foxn1+,Gt(ROSA)26Sortm1(Tbx1)Rche/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NHsd

 MP:0011877 absent liver "absence of the bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage" [MGI:Colin_McKerlie]
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Allelic Composition: Myo10m1J/Myo10m1J
Genetic Background: involves: C57BL/6J

 MP:0013022 increased Ly6C high monocyte number "increase in the number of monocytes that express high levels of Ly6C and low MHC class II that represent a subset of circulating inflammatory monocytes that are recruited to infected or inflamed tissues" [MGI:Annie_Speak]
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Allelic Composition: Myo10tm2(KOMP)Wtsi/Myo10tm2(KOMP)Wtsi
Genetic Background: C57BL/6N-Myo10tm2(KOMP)Wtsi/Wtsi

 MP:0013026 decreased Ly6C low monocyte number "decrease in the number of monocytes that express low levels of Ly6C and low MHC class II that represent a subset of patrolling monocytes" [MGI:Annie_Speak]
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Allelic Composition: Myo10tm2(KOMP)Wtsi/Myo10tm2(KOMP)Wtsi
Genetic Background: C57BL/6N-Myo10tm2(KOMP)Wtsi/Wtsi

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000022272 Myo10 / F8VQB6 / Mus musculus myosin X (Myo10), transcript variant 3, mRNA. / Q9HD67* / myosin X*  / complex
 ENSMUSG00000062825 Actg1 / P63260 / Actin, cytoplasmic 2 Actin, cytoplasmic 2, N-terminally processed / P63261* / actin gamma 1*  / reaction / complex
 ENSMUSG00000029580 Actb / P60710 / Actin, cytoplasmic 1 Actin, cytoplasmic 1, N-terminally processed / POTEJ* / P60709* / P0CG39* / actin beta* / POTE ankyrin domain family member J*  / complex / reaction






 

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