ENSMUSG00000039585


Mus musculus

Features
Gene ID: ENSMUSG00000039585
  
Biological name :Myo9a
  
Synonyms : Myo9a / Q8C170 / Unconventional myosin-IXa
  
Possible biological names infered from orthology : B2RTY4 / myosin IXA
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: B
Gene start: 59750896
Gene end: 59928866
  
Corresponding Affymetrix probe sets: 10585956 (MoGene1.0st)   10585970 (MoGene1.0st)   10585972 (MoGene1.0st)   10585974 (MoGene1.0st)   10585976 (MoGene1.0st)   10585978 (MoGene1.0st)   10585980 (MoGene1.0st)   10585982 (MoGene1.0st)   10585984 (MoGene1.0st)   10585986 (MoGene1.0st)   10585988 (MoGene1.0st)   10585990 (MoGene1.0st)   10585992 (MoGene1.0st)   1436307_at (Mouse Genome 430 2.0 Array)   1459991_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000117432
Ensembl peptide - ENSMUSP00000119401
Ensembl peptide - ENSMUSP00000122852
NCBI entrez gene - 270163     See in Manteia.
MGI - MGI:107735
RefSeq - XM_017313400
RefSeq - NM_173018
RefSeq - XM_006511217
RefSeq - XM_006511220
RefSeq - XM_017313399
RefSeq - XM_006511208
RefSeq - XM_006511209
RefSeq - XM_006511210
RefSeq - XM_006511211
RefSeq - XM_006511212
RefSeq - XM_006511213
RefSeq - XM_006511215
RefSeq - XM_006511216
RefSeq Peptide - NP_766606
swissprot - Q8C170
swissprot - D3Z3A8
Ensembl - ENSMUSG00000039585
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 myo9aaENSDARG00000076729Danio rerio
 myo9abENSDARG00000073843Danio rerio
 MYO9AENSGALG00000033618Gallus gallus
 MYO9AENSG00000066933Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Myo9b / myosin IXB / Q13459*ENSMUSG0000000467737
Myo7b / Q99MZ6 / Unconventional myosin-VIIb / Q6PIF6* / myosin VIIB*ENSMUSG0000002438818
Myo7a / P97479 / Unconventional myosin-VIIa / Q13402* / myosin VIIA*ENSMUSG0000003076118
Myo10 / F8VQB6 / Mus musculus myosin X (Myo10), transcript variant 3, mRNA. / Q9HD67* / myosin X*ENSMUSG0000002227217
Myo5a / Q99104 / Unconventional myosin-Va / Q9Y4I1* / myosin VA*ENSMUSG0000003459317
Myo5b / myosin VB / Q9ULV0*ENSMUSG0000002588516
Myo5c / myosin VC / Q9NQX4*ENSMUSG0000003359016
Myo6 / myosin VI / Q9UM54*ENSMUSG0000003357713


Protein motifs (from Interpro)
Interpro ID Name
 IPR000048  IQ motif, EF-hand binding site
 IPR000159  Ras-associating (RA) domain
 IPR000198  Rho GTPase-activating protein domain
 IPR001609  Myosin head, motor domain
 IPR002219  Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
 IPR008936  Rho GTPase activation protein
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR028558  Unconventional myosin-IXa
 IPR029071  Ubiquitin-like domain superfamily
 IPR036023  Class IX myosin, motor domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007018 microtubule-based movement IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0034329 cell junction assembly ISO
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0045198 establishment of epithelial cell apical/basal polarity ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016459 myosin complex IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003774 motor activity IEA
 molecular_functionGO:0003777 microtubule motor activity IEA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0005096 GTPase activator activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008017 microtubule binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Rho GTPase cycle


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000825 dilated lateral ventricles "increase over the normal size of the horseshoe-shaped cavities of the cerebrum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:38857]
Show

Allelic Composition: Fmnl1tm1.2Sdb/Fmnl1tm1.2Sdb,Lyz2tm1(cre)Ifo/Lyz2tm1(cre)Ifo
Genetic Background: involves: C3H * C57BL/6 * FVB/N

 MP:0000826 abnormal third ventricle morphology "malformation or absence of the narrow cleft inferior to the corpus callosum, within the diencephalon, between the paired thalami; its floor is formed by the hypothalamus, its anterior wall by the lamina terminalis, and its roof by ependyma; it communicates with the fourth ventricle by the cerebral aqueduct, and with the lateral ventricles by the interventricular foramina" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Fmnl1tm1.2Sdb/Fmnl1tm1.2Sdb,Lyz2tm1(cre)Ifo/Lyz2tm1(cre)Ifo
Genetic Background: involves: C3H * C57BL/6 * FVB/N

 MP:0000917 obstructive hydrocephaly "hydrocephaly due to a block in cerebralspinal fluid flow in the ventricular system" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fmnl1tm1.2Sdb/Fmnl1tm1.2Sdb,Lyz2tm1(cre)Ifo/Lyz2tm1(cre)Ifo
Genetic Background: involves: C3H * C57BL/6 * FVB/N

 MP:0001015 small superior cervical ganglion "reduced size of the group of neurons that is the largest of the ganglia of the sympathetic trunk; normally lies at the base of the skull and innervates the head and neck" [J:23882]
Show

Allelic Composition: Esr2tm1.1Gust/Esr2tm1.1Gust
Genetic Background: B6J.129X1(Cg)-Esr2tm1.1Gust

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
Show

Allelic Composition: Fmnl1tm1.2Sdb/Fmnl1tm1.2Sdb,Lyz2tm1(cre)Ifo/Lyz2tm1(cre)Ifo
Genetic Background: involves: C3H * C57BL/6 * FVB/N

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Fmnl1tm1.2Sdb/Fmnl1tm1.2Sdb,Lyz2tm1(cre)Ifo/Lyz2tm1(cre)Ifo
Genetic Background: involves: C3H * C57BL/6 * FVB/N

 MP:0003584 bifid ureter "cleft of the ureter into two parts or branches" [ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Esr2tm1.1Gust/Esr2tm1.1Gust
Genetic Background: B6J.129X1(Cg)-Esr2tm1.1Gust

 MP:0003826 abnormal Mullerian duct morphology "malformation of the transient embryonic tubes that empty into the cloaca and in the female develop into the oviducts, uterus, and vagina" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Esr2tm1.1Gust/Esr2tm1.1Gust
Genetic Background: B6J.129X1(Cg)-Esr2tm1.1Gust

 MP:0003827 abnormal Wolffian duct morphology "malformation of the transient embryonic tubes that empty into the cloca and degenerate in the male " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Esr2tm1.1Gust/Esr2tm1.1Gust
Genetic Background: B6J.129X1(Cg)-Esr2tm1.1Gust

 MP:0004160 retroesophageal right subclavian artery "the subclavian artery aberrantly originates from the aortic arch distal to the origin of the left subclavian artery, i.e., it is the last branch of the aortic arch" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Esr2tm1.1Gust/Esr2tm1.1Gust
Genetic Background: B6J.129X1(Cg)-Esr2tm1.1Gust

 MP:0004613 fusion of vertebral arches "improper union of the dorsal part of adjacent vertebra" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Esr2tm1.1Gust/Esr2tm1.1Gust
Genetic Background: B6J.129X1(Cg)-Esr2tm1.1Gust

 MP:0005537 abnormal cerebral aqueduct "anomalous structure of the channel in the mesencephalon that connets the third and fourth ventricles" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fmnl1tm1.2Sdb/Fmnl1tm1.2Sdb,Lyz2tm1(cre)Ifo/Lyz2tm1(cre)Ifo
Genetic Background: involves: C3H * C57BL/6 * FVB/N

Allelic Composition: Myo9atm1.2Bah/Myo9atm1.2Bah,Rhobtm1Gcp/Rhobtm1Gcp
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

 MP:0006093 arteriovenous malformation "fusion of an artery and vein without an intervening capillary bed" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93125]
Show

Allelic Composition: Esr2tm1.1Gust/Esr2tm1.1Gust
Genetic Background: B6J.129X1(Cg)-Esr2tm1.1Gust

 MP:0008536 enlarged third ventricle "increased size of the narrow cleft inferior to the corpus callosum, within the diencephalon, between the paired thalami; its floor is formed by the hypothalamus, its anterior wall by the lamina terminalis, and its roof by ependyma; it communicates with the fourth ventricle by the cerebral aqueduct, and with the lateral ventricles by the interventricular foramina" [MESH:A08.186.211.276.840, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fmnl1tm1.2Sdb/Fmnl1tm1.2Sdb,Lyz2tm1(cre)Ifo/Lyz2tm1(cre)Ifo
Genetic Background: involves: C3H * C57BL/6 * FVB/N

 MP:0009689 abnormal neural tube ventricular layer morphology "any structural anomaly of the layer of undifferentiated, proliferating cells that line the neural tube lumen" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fmnl1tm1.2Sdb/Fmnl1tm1.2Sdb,Lyz2tm1(cre)Ifo/Lyz2tm1(cre)Ifo
Genetic Background: involves: C3H * C57BL/6 * FVB/N

 MP:0013228 brain ventricle stenosis "abnormal narrowing or constriction of one or more of the four communicating cavities within the brain that are continuous with the central canal of the spinal cord" [MGI:anna]
Show

Allelic Composition: Fmnl1tm1.2Sdb/Fmnl1tm1.2Sdb,Lyz2tm1(cre)Ifo/Lyz2tm1(cre)Ifo
Genetic Background: involves: C3H * C57BL/6 * FVB/N

 MP:0013848 subcutaneous edema "accumulation of watery or serous fluid in the subcutaneous region below the skin" [MGI:csmith]
Show

Allelic Composition: Esr2tm1.1Gust/Esr2tm1.1Gust
Genetic Background: B6J.129X1(Cg)-Esr2tm1.1Gust

 MP:0013969 reduced sympathetic cervical ganglion size 
Show

Allelic Composition: Esr2tm1.1Gust/Esr2tm1.1Gust
Genetic Background: B6J.129X1(Cg)-Esr2tm1.1Gust

 MP:0013971 blood in lymph vessels 
Show

Allelic Composition: Esr2tm1.1Gust/Esr2tm1.1Gust
Genetic Background: B6J.129X1(Cg)-Esr2tm1.1Gust

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr