ENSMUSG00000033577


Mus musculus

Features
Gene ID: ENSMUSG00000033577
  
Biological name :Myo6
  
Synonyms : Myo6 / myosin VI
  
Possible biological names infered from orthology : Q9UM54
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: E1
Gene start: 80165031
Gene end: 80311729
  
Corresponding Affymetrix probe sets: 10587446 (MoGene1.0st)   1421120_at (Mouse Genome 430 2.0 Array)   1433942_at (Mouse Genome 430 2.0 Array)   1435559_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000108891
Ensembl peptide - ENSMUSP00000075501
Ensembl peptide - ENSMUSP00000108893
Ensembl peptide - ENSMUSP00000139228
Ensembl peptide - ENSMUSP00000139019
Ensembl peptide - ENSMUSP00000036181
NCBI entrez gene - 17920     See in Manteia.
MGI - MGI:104785
RefSeq - XM_017313191
RefSeq - XM_006510835
RefSeq - XM_006510836
RefSeq - XM_006510838
RefSeq - XM_011242667
RefSeq - XM_011242668
RefSeq - XM_011242669
RefSeq - XM_011242670
RefSeq - NM_001039546
RefSeq Peptide - NP_001034635
swissprot - E9Q175
swissprot - E9Q174
swissprot - E9Q3L1
swissprot - V9GX76
swissprot - V9GXM4
swissprot - E9PVU0
Ensembl - ENSMUSG00000033577
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 myo6aENSDARG00000044016Danio rerio
 myo6bENSDARG00000042141Danio rerio
 MYO6ENSGALG00000015898Gallus gallus
 MYO6ENSG00000196586Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Myo5a / Q99104 / Unconventional myosin-Va / Q9Y4I1* / myosin VA*ENSMUSG0000003459328
Myo5b / myosin VB / Q9ULV0*ENSMUSG0000002588527
Myo9a / Q8C170 / Unconventional myosin-IXa / B2RTY4* / myosin IXA*ENSMUSG0000003958527
Myo10 / F8VQB6 / Mus musculus myosin X (Myo10), transcript variant 3, mRNA. / Q9HD67* / myosin X*ENSMUSG0000002227226
Myo5c / myosin VC / Q9NQX4*ENSMUSG0000003359026
Myo7a / P97479 / Unconventional myosin-VIIa / Q13402* / myosin VIIA*ENSMUSG0000003076126
Myo7b / Q99MZ6 / Unconventional myosin-VIIb / Q6PIF6* / myosin VIIB*ENSMUSG0000002438826
Myo9b / myosin IXB / Q13459*ENSMUSG0000000467725


Protein motifs (from Interpro)
Interpro ID Name
 IPR001609  Myosin head, motor domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR032412  Myosin VI, cargo binding domain
 IPR036114  Class VI myosin, motor domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006897 endocytosis IEA
 biological_processGO:0007018 microtubule-based movement IEA
 biological_processGO:0030330 DNA damage response, signal transduction by p53 class mediator IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0051046 regulation of secretion IEA
 cellular_componentGO:0001726 ruffle IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005902 microvillus IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016459 myosin complex IEA
 cellular_componentGO:0016591 DNA-directed RNA polymerase II, holoenzyme IEA
 cellular_componentGO:0030139 endocytic vesicle IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0031941 filamentous actin IEA
 cellular_componentGO:0031965 nuclear membrane IEA
 cellular_componentGO:0032587 ruffle membrane IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 cellular_componentGO:0045177 apical part of cell IEA
 cellular_componentGO:0045334 clathrin-coated endocytic vesicle IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003774 motor activity IEA
 molecular_functionGO:0003777 microtubule motor activity IEA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008017 microtubule binding IEA
 molecular_functionGO:0045296 cadherin binding IEA
 molecular_functionGO:0051015 actin filament binding IEA


Pathways (from Reactome)
Pathway description
Gap junction degradation
Trafficking of AMPA receptors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000032 cochlear degeneration "a retrogressive impairment of function or destruction of the part of the inner ear forms the anterior part of the labyrinth, is conical, and is concerned with hearing" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Myo6sv/Myo6sv
Genetic Background: involves: B10.HA/(33NX)Sn * SEC/1Gn

 MP:0000034 abnormal vestibule morphology "malformed cavity between the semicircular canals and the cochlea of the inner ear" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:1776]
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Allelic Composition: Myo15mpc190H/Myo15mpc190H
Genetic Background: involves: BALB/c * C3H/HeH * C57BL/6J

 MP:0000042 abnormal organ of Corti "abnormalities associated with the highly specialized epithelium in the floor of the ductus cochlearis; also referred to a spiral organ (organum spirale), or acoustic papilla" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Myo15sh2/Myo15sh2,Myo6sv/Myo6sv
Genetic Background: involves: B10.HA/(33NX)Sn

 MP:0000043 organ of Corti degeneration "a retrogressive impairment of function or destruction of the highly specialized epithelium in the floor of the ductus cochlearis" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Myo6sv/Myo6sv
Genetic Background: involves: B10.HA/(33NX)Sn * C57BL/6J

Allelic Composition: Myo6sv/Myo6sv
Genetic Background: involves: B10.HA/(33NX)Sn * SEC/1Gn

Allelic Composition: Myo6chl/Myo6chl
Genetic Background: involves: C57BL/6JAnu

 MP:0000044 absent organ of Corti "absence of the highly specialized epithelium in the floor of the ductus cochlearis " [J:54408]
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Allelic Composition: Sox11tm1.2Llei/Sox11tm1.2Llei
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Cpetm1Yplo/Cpetm1Yplo
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Myo15sh2/Myo15sh2,Myo6sv/Myo6sv
Genetic Background: involves: B10.HA/(33NX)Sn

 MP:0001394 circling "repeated, compulsive movement in a circle; often associated with inner ear defects" [MGI:CLS, J:61295]
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Allelic Composition: Tgfawa1/Tgfawa1
Genetic Background: Not Specified

Allelic Composition: Myo6sv/Myo6sv
Genetic Background: involves: B10.HA/(33NX)Sn * C57BL/6J

Allelic Composition: Myo6sv-2J/Myo6sv-2J
Genetic Background: B6.Cg-Myo6sv-2J/J

Allelic Composition: Myo6sv/Myo6sv
Genetic Background: B6 x STOCK Tyrc-ch Bmp5se +/+ Myo6sv/J

Allelic Composition: Myo6twt/Myo6twt
Genetic Background: involves: C57BL/6J

Allelic Composition: Myo6sv-3J/Myo6sv-3J
Genetic Background: C57BL/6J-Myo6sv-3J

Allelic Composition: Myo6sv-4J/Myo6sv-4J
Genetic Background: 129S1/SvImJ-Myo6sv-4J/J

Allelic Composition: In(9Bmp5-Myo6)5Rl/Bmp5se Myo6sv
Genetic Background: involves: 101/Rl * C3H/Rl

Allelic Composition: Myo6sv/Myo6sv
Genetic Background: involves: B10.HA/(33NX)Sn * SEC/1Gn

Allelic Composition: Myo6m2Btlr/Myo6m2Btlr
Genetic Background: C57BL/6J-Myo6m2Btlr

 MP:0001395 bi-directional circling "circling behavior exhibited in both clockwise and counterclockwise directions" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Myo6M1Btlr/Myo6M1Btlr
Genetic Background: C57BL/6J-Myo6M1Btlr

Allelic Composition: Myo6M1Btlr/Myo6M1Btlr
Genetic Background: Not Specified

Allelic Composition: Myo6sv/Myo6sv
Genetic Background: involves: B10.HA/(33NX)Sn * SEC/1Gn

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
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Allelic Composition: Cpetm1Yplo/Cpetm1Yplo
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Myo6twt/Myo6twt
Genetic Background: involves: C57BL/6J

Allelic Composition: Myo6sv/Myo6sv
Genetic Background: involves: B10.HA/(33NX)Sn * SEC/1Gn

Allelic Composition: Myo6m2Btlr/Myo6m2Btlr
Genetic Background: C57BL/6J-Myo6m2Btlr

 MP:0001408 stereotypic behavior "repetitive, invariant, perseverative motor patterns that do not appear to be purposeful" [What s wrong with my mouse?:ISBN 0-471-31639-3]
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Allelic Composition: Cpetm1Yplo/Cpetm1Yplo
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001410 head bobbing "compulsive up and down movement of the head" [J:17123]
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Allelic Composition: Myo6sv/Myo6sv
Genetic Background: involves: B10.HA/(33NX)Sn * C57BL/6J

Allelic Composition: Myo6M1Btlr/Myo6M1Btlr
Genetic Background: C57BL/6J-Myo6M1Btlr

 MP:0001489 decreased startle reflex "greater threshold or less severe reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, What s Wrong With My Mouse?:ISBN 0-471-31639-3]
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Allelic Composition: Myo6twt/Myo6twt
Genetic Background: involves: C57BL/6J

 MP:0001522 impaired swimming "reduced ability or inability to swim" [J:45446, J:39081]
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Allelic Composition: Xrcc5tm1Nus/Xrcc5tm1Nus
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Myo6sv/Myo6sv
Genetic Background: B6 x STOCK Tyrc-ch Bmp5se +/+ Myo6sv/J

Allelic Composition: Myo6twt/Myo6twt
Genetic Background: involves: C57BL/6J

Allelic Composition: Myo6sv/Myo6sv
Genetic Background: involves: B10.HA/(33NX)Sn * SEC/1Gn

 MP:0001525 impaired balance "reduced ability of an animal to maintain equilibrium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:64962, J:17123]
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Allelic Composition: Tgfawa1/Tgfawa1
Genetic Background: Not Specified

 MP:0001526 abnormal placing response "altered ability to stretch and lift the forelimbs and head to grab a close edge " [J:66943, MGI:cml]
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Allelic Composition: Tgfawa1/Tgfawa1
Genetic Background: Not Specified

 MP:0001921 reduced fertility "diminished ability to produce live offspring" [J:65030]
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Allelic Composition: Cpetm1Yplo/Cpetm1Yplo
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001961 abnormal reflex "anomalies in an involuntary response to a peripheral stimulus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Myo7ash1/Myo7ash1
Genetic Background: SH1/LeJ

 MP:0001967 deafness "inability to hear" [J:57651]
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Allelic Composition: Myo6sv-2J/Myo6sv-2J
Genetic Background: B6.Cg-Myo6sv-2J/J

Allelic Composition: Myo6sv-4J/Myo6sv-4J
Genetic Background: 129S1/SvImJ-Myo6sv-4J/J

Allelic Composition: Myo6sv/Myo6sv
Genetic Background: involves: B10.HA/(33NX)Sn * SEC/1Gn

Allelic Composition: Myo6chl/Myo6chl
Genetic Background: involves: C57BL/6JAnu

Allelic Composition: Myo6mpc285H/Myo6mpc285H
Genetic Background: involves: BALB/c * C3H/HeH * C57BL/6J

 MP:0002730 head shaking "compulsive movement of the head in the horizontal plane" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:274]
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Allelic Composition: Myo6sv-4J/Myo6sv-4J
Genetic Background: 129S1/SvImJ-Myo6sv-4J/J

 MP:0002833 increased heart weight "greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
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Allelic Composition: Myo6chl/Myo6chl
Genetic Background: involves: C57BL/6JAnu

 MP:0002857 cochlear ganglion degeneration "loss of neural cell bodies in the group of nerve cell bodies that conveys auditory sensation from the organ of Corti to the hindbrain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Myo6sv/Myo6sv
Genetic Background: involves: B10.HA/(33NX)Sn * SEC/1Gn

Allelic Composition: Myo6chl/Myo6chl
Genetic Background: involves: C57BL/6JAnu

 MP:0002895 abnormal otolithic membrane "malformations of the gelatinous membrane surmounting the acoustic maculae of the saccule and utricle and containing minute calciferous particles (otoliths)" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Myo6sv/Myo6sv
Genetic Background: involves: B10.HA/(33NX)Sn * SEC/1Gn

 MP:0003150 detached tectorial membrane "tectorial membrane is abnormally detached from the cochlear epithelium or spiral limbus" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:77634]
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Allelic Composition: Myo6sv/Myo6sv
Genetic Background: involves: B10.HA/(33NX)Sn * SEC/1Gn

 MP:0003308 abnormal cochlear sensory epithelium 
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Allelic Composition: Myo6sv/Myo6sv
Genetic Background: involves: B10.HA/(33NX)Sn * C57BL/6J

 MP:0004298 vestibular ganglion degeneration "loss of the group of bipolar sensory nerve cell bodies concerned with equilibration that form a swelling on the vestibular part of the eighth cranial nerve in the fundus of the internal acoustic meatus" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Myo6sv/Myo6sv
Genetic Background: involves: B10.HA/(33NX)Sn * SEC/1Gn

 MP:0004324 vestibular hair cell degeneration "degeneration or loss of the sensory epithelial cells of the maculae and cristae of the membranous labyrinth of the inner ear which are normally in synaptic contact with the vestibular nerve" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Tgfawa1/Tgfawa1
Genetic Background: Not Specified

Allelic Composition: Myo6sv/Myo6sv
Genetic Background: involves: B10.HA/(33NX)Sn * SEC/1Gn

Allelic Composition: Myo6chl/Myo6chl
Genetic Background: involves: C57BL/6JAnu

 MP:0004328 decreased vestibular hair cell number "decreased number of cells in the sensory epithelium of the maculae and cristae of the membranous labyrinth of the internal ear which are normally in synaptic contact with the vestibular nerve" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Myo6chl/Myo6chl
Genetic Background: involves: C57BL/6JAnu

 MP:0004331 saccular macula degeneration "degeneration or loss of the oval neuroepithelial sensory receptor in the anterior wall of the saccule" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Myo6sv/Myo6sv
Genetic Background: involves: B10.HA/(33NX)Sn * SEC/1Gn

 MP:0004334 utricular macular degeneration "degeneration or loss of the neuroepithelial sensory receptor in the inferolateral wall of the utricle" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Myo6sv/Myo6sv
Genetic Background: involves: B10.HA/(33NX)Sn * SEC/1Gn

 MP:0004362 cochlear hair cell degeneration "degeneration or loss of the sensory epithelial cells of the cochlea; these cells are in synaptic contact with the auditory nerve" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tgfawa1/Tgfawa1
Genetic Background: Not Specified

Allelic Composition: Myo6sv/Myo6sv
Genetic Background: involves: B10.HA/(33NX)Sn * C57BL/6J

 MP:0004363 stria vascularis degeneration "degeneration or loss of the stratified, secretory epithelium which lines the upper part of the cochlear spiral ligament and maintains potassium ion homeostasis in the endolymph" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Myo6sv/Myo6sv
Genetic Background: involves: B10.HA/(33NX)Sn * SEC/1Gn

 MP:0004398 cochlear inner hair cell degeneration "degeneration or loss of the single row of flask-shaped inner hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Tgfawa1/Tgfawa1
Genetic Background: Not Specified

Allelic Composition: Myo6sv/Myo6sv
Genetic Background: involves: B10.HA/(33NX)Sn * C57BL/6J

 MP:0004404 cochlear outer hair cell degeneration "degeneration or loss of the columnar outer hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Tgfawa1/Tgfawa1
Genetic Background: Not Specified

Allelic Composition: Myo6sv/Myo6sv
Genetic Background: involves: B10.HA/(33NX)Sn * C57BL/6J

 MP:0004409 abnormal neuroepithelium of ampullary crest "any structural abnormality in the specialized sensory hair cells of the ampullary crest of the ampulla of each semicircular duct" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Myo6sv/Myo6sv
Genetic Background: involves: B10.HA/(33NX)Sn * SEC/1Gn

 MP:0004416 absent cochlear nerve compound action potential "absence of the combined potentials resulting from activation of the auditory division of the eighth cranial nerve" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Myo6sv/Myo6sv
Genetic Background: involves: B10.HA/(33NX)Sn * C57BL/6J

 MP:0004491 abnormal orientation of outer hair cell stereociliary bundles "misorientation or rotation of outer hair cell (OHC) stereociliary bundles, resulting in defective planar cell polarity of the inner ear sensory epithelium " [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Myo6chl/Myo6chl
Genetic Background: involves: C57BL/6JAnu

 MP:0004492 abnormal orientation of inner hair cell stereociliary bundles "misorientation or rotation of inner hair cell (IHC) stereociliary bundles, resulting in defective planar cell polarity of the inner ear sensory epithelium" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Myo6chl/Myo6chl
Genetic Background: involves: C57BL/6JAnu

 MP:0004515 abnormal vestibular hair cell stereociliary bundle morphology "any structural anomaly or disruption of the typical staircase-like arrangement of the mechanosensitive hair bundles which are composed of thick long microvilli (stereocilia) and are located at the apical end of vestibular hair cells of the utricle and saccule" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Myo6chl/Myo6chl
Genetic Background: involves: C57BL/6JAnu

 MP:0004516 fused vestibular hair cell stereocilia "coalescence of the nonmotile, actin-filled specialized microvilli (stereocilia) normally arrayed on vestibular hair cells, often resulting in giant stereocilia" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Myo6chl/Myo6chl
Genetic Background: involves: C57BL/6JAnu

 MP:0004521 abnormal cochlear hair cell stereociliary bundle morphology "any structural anomaly or disruption of the typical pattern of arrangement of mechanosensitive hair bundles which are composed of thick long microvilli (stereocilia) and are located at the apical end of cochlear inner and outer hair cells" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Tgfawa1/Tgfawa1
Genetic Background: Not Specified

Allelic Composition: Myo15sh2/Myo15sh2,Myo6sv/Myo6sv
Genetic Background: involves: B10.HA/(33NX)Sn

Allelic Composition: Myo6twt/Myo6twt
Genetic Background: involves: C57BL/6J

 MP:0004523 decreased cochlear hair cell stereocilia number "decreased number (or less than the expected 100 or so) of the nonmotile, actin-filled specialized microvilli (stereocilia) normally arrayed on cochlear inner and outer hair cells" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Myo6twt/Myo6twt
Genetic Background: involves: C57BL/6J

 MP:0004524 short cochlear hair cell stereocilia "reduced length of the nonmotile, actin-filled specialized microvilli (stereocilia) which are normally arrayed on cochlear inner and outer hair cells" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Myo15sh2/Myo15sh2,Myo6sv/Myo6sv
Genetic Background: involves: B10.HA/(33NX)Sn

 MP:0004528 fused outer hair cell stereocilia "coalescence of the nonmotile, actin-filled specialized microvilli (stereocilia) normally arrayed on cochlear outer hair cells, often resulting in giant stereocilia" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Myo6sv/Myo6sv
Genetic Background: involves: B10.HA/(33NX)Sn * C57BL/6J

 MP:0004529 decreased outer hair cell stereocilia number "decreased number (or less than the expected 100 or so) of the nonmotile, actin-filled specialized microvilli (stereocilia) normally arrayed on cochlear outer hair cells" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Myo6chl/Myo6chl
Genetic Background: involves: C57BL/6JAnu

 MP:0004533 fused inner hair cell stereocilia "coalescence of the nonmotile, actin-filled specialized microvilli (stereocilia) normally arrayed on cochlear inner hair cells, often resulting in giant stereocilia" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Myo6sv/Myo6sv
Genetic Background: involves: B10.HA/(33NX)Sn * C57BL/6J

 MP:0004534 decreased inner hair cell stereocilia number "decreased number (or less than the expected 100 or so) of the nonmotile, actin-filled specialized microvilli (stereocilia) normally arrayed on cochlear inner hair cells" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Myo6chl/Myo6chl
Genetic Background: involves: C57BL/6JAnu

 MP:0004589 abnormal cochlear hair cell development "atypical initial production, differentiation, migration or maturation of the sensory epithelial cells of the cochlea" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Tgfawa1/Tgfawa1
Genetic Background: Not Specified

 MP:0004742 abnormal vestibular system physiology "any functional anomaly of the sensory system responsible for the sense of head position and movement of the body through space; such anomalies may include impaired balance, dizziness, poor regulation of postural muscle tone and inability to detect quick movements of the head " [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Myo6chl/Myo6chl
Genetic Background: involves: C57BL/6JAnu

 MP:0004748 increased susceptibility to age-related hearing loss "greater than normal loss of hearing associated with advancing age, manifest as reduced ability to perceive or discriminate sounds; the pattern and age of onset vary" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Myo6sv/Myo6sv
Genetic Background: involves: B10.HA/(33NX)Sn * C57BL/6J

 MP:0004813 absent linear vestibular evoked potential "absence of the biphasic response elicited by linear acceleration transients (usually jerk pulses to an animal s head)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Myo6sv/Myo6sv
Genetic Background: B6 x STOCK Tyrc-ch Bmp5se +/+ Myo6sv/J

 MP:0004814 reduced linear vestibular evoked potential "reduction of the biphasic response elicited by linear acceleration transients (usually jerk pulses to an animal s head)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Grid2ho-4J/Grid2ho-4J
Genetic Background: DBA/2J-Grid2ho-4J/J

 MP:0005191 head tilt "condition in which the portion of the body containing the brain and organs of sight, hearing, taste, and smell lists to the side" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Myo6sv-3J/Myo6sv-3J
Genetic Background: C57BL/6J-Myo6sv-3J

Allelic Composition: Myo6M1Btlr/Myo6M1Btlr
Genetic Background: Not Specified

 MP:0005307 head tossing "compulsive flailing of the head in multiple directions" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tgfawa1/Tgfawa1
Genetic Background: Not Specified

Allelic Composition: Myo6sv/Myo6sv
Genetic Background: involves: B10.HA/(33NX)Sn * C57BL/6J

Allelic Composition: Myo6sv-2J/Myo6sv-2J
Genetic Background: B6.Cg-Myo6sv-2J/J

Allelic Composition: Myo6sv-4J/Myo6sv-4J
Genetic Background: 129S1/SvImJ-Myo6sv-4J/J

Allelic Composition: Myo6sv/Myo6sv
Genetic Background: involves: B10.HA/(33NX)Sn * SEC/1Gn

Allelic Composition: Myo6m2Btlr/Myo6m2Btlr
Genetic Background: C57BL/6J-Myo6m2Btlr

 MP:0005330 cardiomyopathy "diseases of the heart (myocardium); may result from many causes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:80681]
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Allelic Composition: Myo6chl/Myo6chl
Genetic Background: involves: C57BL/6JAnu

 MP:0005551 abnormal eye electrophysiology "abnormal function of the eye as determined through electrophysiological recordings from single cells or summary recordings from multiple cells (e.g. electroretinogram)" [NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator]
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Allelic Composition: Myo6sv/Myo6sv
Genetic Background: involves: B10.HA/(33NX)Sn * C57BL/6J

 MP:0006325 impaired hearing "reduced ability to percieve auditory stimuli" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: In(9Bmp5-Myo6)5Rl/Bmp5se Myo6sv
Genetic Background: involves: 101/Rl * C3H/Rl

Allelic Composition: Myo6chl/Myo6chl
Genetic Background: involves: C57BL/6JAnu

 MP:0006358 absent pinna reflex "complete failure to respond to an auditory stimulus by a characteristic ear twitch" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Tgfawa1/Tgfawa1
Genetic Background: Not Specified

Allelic Composition: Myo6chl/Myo6chl
Genetic Background: involves: C57BL/6JAnu

 MP:0010323 retropulsion "a tendency to step or walk backwards" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tgfawa1/Tgfawa1
Genetic Background: Not Specified

 MP:0011062 abnormal outer hair cell kinocilium morphology "any structural anomaly of the nonmotile primary cilium that is found at the apical surface of outer hair cells" [GO:0060091]
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Allelic Composition: Myo6chl/Myo6chl
Genetic Background: involves: C57BL/6JAnu

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Rag1tm1Mom/Rag1tm1Mom,Rasa3scat/Rasa3scat
Genetic Background: involves: 129S7/SvEvBrd * BALB/cBy

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
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Allelic Composition: Myo6twt/Myo6twt
Genetic Background: involves: C57BL/6J

Allelic Composition: Myo6sv-4J/Myo6sv-4J
Genetic Background: 129S1/SvImJ-Myo6sv-4J/J

Allelic Composition: Myo6chl/Myo6chl
Genetic Background: involves: C57BL/6JAnu

 MP:0020084 short ears "reduced length of the ears" [GOC:NV]
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Allelic Composition: In(9Bmp5-Myo6)5Rl/Bmp5se Myo6sv
Genetic Background: involves: 101/Rl * C3H/Rl

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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