ENSMUSG00000004677


Mus musculus

Features
Gene ID: ENSMUSG00000004677
  
Biological name :Myo9b
  
Synonyms : Myo9b / myosin IXB
  
Possible biological names infered from orthology : Q13459
  
Species: Mus musculus
  
Chr. number: 8
Strand: 1
Band: B3.3
Gene start: 71272714
Gene end: 71360713
  
Corresponding Affymetrix probe sets: 10572533 (MoGene1.0st)   1418031_at (Mouse Genome 430 2.0 Array)   1438533_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000148528
Ensembl peptide - ENSMUSP00000131635
Ensembl peptide - ENSMUSP00000071827
Ensembl peptide - ENSMUSP00000129220
Ensembl peptide - ENSMUSP00000148316
NCBI entrez gene - 17925     See in Manteia.
MGI - MGI:106624
RefSeq - XM_017312607
RefSeq - XM_017312598
RefSeq - XM_017312599
RefSeq - XM_017312600
RefSeq - XM_017312602
RefSeq - XM_017312603
RefSeq - XM_017312604
RefSeq - XM_017312605
RefSeq - XM_017312606
RefSeq - NM_001142322
RefSeq - NM_001142323
RefSeq - NM_015742
RefSeq - XM_006509566
RefSeq - XM_006509567
RefSeq - XM_006509568
RefSeq - XM_006509569
RefSeq - XM_006509571
RefSeq - XM_006509572
RefSeq - XM_006509575
RefSeq - XM_006509576
RefSeq - XM_006509577
RefSeq - XM_006509578
RefSeq - XM_006509579
RefSeq - XM_006509580
RefSeq - XM_006509581
RefSeq - XM_006509582
RefSeq - XM_006509584
RefSeq - XM_006509585
RefSeq - XM_006509586
RefSeq Peptide - NP_001135794
RefSeq Peptide - NP_001135795
RefSeq Peptide - NP_056557
swissprot - A0A1D5RLW4
swissprot - A0A1D5RLD1
swissprot - E9QKV6
swissprot - E9PZW8
swissprot - E9PWZ6
Ensembl - ENSMUSG00000004677
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 myo9bENSDARG00000077410Danio rerio
 MYO9BENSDARG00000078313Danio rerio
 MYO9BENSGALG00000003717Gallus gallus
 MYO9BENSG00000099331Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Myo9a / Q8C170 / Unconventional myosin-IXa / B2RTY4* / myosin IXA*ENSMUSG0000003958545
Myo7a / P97479 / Unconventional myosin-VIIa / Q13402* / myosin VIIA*ENSMUSG0000003076121
Myo7b / Q99MZ6 / Unconventional myosin-VIIb / Q6PIF6* / myosin VIIB*ENSMUSG0000002438820
Myo5c / myosin VC / Q9NQX4*ENSMUSG0000003359019
Myo10 / F8VQB6 / Mus musculus myosin X (Myo10), transcript variant 3, mRNA. / Q9HD67* / myosin X*ENSMUSG0000002227219
Myo5a / Q99104 / Unconventional myosin-Va / Q9Y4I1* / myosin VA*ENSMUSG0000003459319
Myo5b / myosin VB / Q9ULV0*ENSMUSG0000002588519
Myo6 / myosin VI / Q9UM54*ENSMUSG0000003357715


Protein motifs (from Interpro)
Interpro ID Name
 IPR000048  IQ motif, EF-hand binding site
 IPR000159  Ras-associating (RA) domain
 IPR000198  Rho GTPase-activating protein domain
 IPR001609  Myosin head, motor domain
 IPR002219  Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
 IPR008936  Rho GTPase activation protein
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR028557  Unconventional myosin-IXb
 IPR029071  Ubiquitin-like domain superfamily
 IPR036023  Class IX myosin, motor domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007018 microtubule-based movement IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0030048 actin filament-based movement IEA
 biological_processGO:0035023 regulation of Rho protein signal transduction IEA
 biological_processGO:0035385 Roundabout signaling pathway IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005884 actin filament IEA
 cellular_componentGO:0005938 cell cortex IEA
 cellular_componentGO:0016459 myosin complex IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0000146 microfilament motor activity IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003774 motor activity IEA
 molecular_functionGO:0003777 microtubule motor activity IEA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0005096 GTPase activator activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005516 calmodulin binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008017 microtubule binding IEA
 molecular_functionGO:0016887 ATPase activity IEA
 molecular_functionGO:0017048 Rho GTPase binding IEA
 molecular_functionGO:0043531 ADP binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0048495 Roundabout binding IEA


Pathways (from Reactome)
Pathway description
Rho GTPase cycle
Regulation of actin dynamics for phagocytic cup formation
SLIT2:ROBO1 increases RHOA activity


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000221 decreased WBC count "fewer than normal numbers of WBCs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Aiptm1Bra/Aip+
Genetic Background: Not Specified

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Aiptm1Bra/Aip+
Genetic Background: Not Specified

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Aiptm1Bra/Aip+
Genetic Background: Not Specified

 MP:0003799 impaired macrophage migration "defect in the ability of macrophages to move up a chemotactic gradient" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Aiptm1Bra/Aip+
Genetic Background: Not Specified

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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