ENSMUSG00000024388


Mus musculus

Features
Gene ID: ENSMUSG00000024388
  
Biological name :Myo7b
  
Synonyms : Myo7b / Q99MZ6 / Unconventional myosin-VIIb
  
Possible biological names infered from orthology : myosin VIIB / Q6PIF6
  
Species: Mus musculus
  
Chr. number: 18
Strand: -1
Band: B1
Gene start: 31959234
Gene end: 32036961
  
Corresponding Affymetrix probe sets: 10457967 (MoGene1.0st)   1420426_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000118046
NCBI entrez gene - 17922     See in Manteia.
MGI - MGI:107709
RefSeq - NM_032394
RefSeq Peptide - NP_115770
swissprot - Q99MZ6
Ensembl - ENSMUSG00000024388
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 myo7bbENSDARG00000077201Danio rerio
 si:ch73-194h10.2ENSDARG00000044441Danio rerio
 MYO7BENSGALG00000001936Gallus gallus
 MYO7BENSG00000169994Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Myo7a / P97479 / Unconventional myosin-VIIa / Q13402* / myosin VIIA*ENSMUSG0000003076154
Myo10 / F8VQB6 / Mus musculus myosin X (Myo10), transcript variant 3, mRNA. / Q9HD67* / myosin X*ENSMUSG0000002227225
Myo9a / Q8C170 / Unconventional myosin-IXa / B2RTY4* / myosin IXA*ENSMUSG0000003958523
Myo5a / Q99104 / Unconventional myosin-Va / Q9Y4I1* / myosin VA*ENSMUSG0000003459322
Myo5c / myosin VC / Q9NQX4*ENSMUSG0000003359021
Myo9b / myosin IXB / Q13459*ENSMUSG0000000467720
Myo5b / myosin VB / Q9ULV0*ENSMUSG0000002588519
Myo6 / myosin VI / Q9UM54*ENSMUSG0000003357716


Protein motifs (from Interpro)
Interpro ID Name
 IPR000048  IQ motif, EF-hand binding site
 IPR000299  FERM domain
 IPR000857  MyTH4 domain
 IPR001452  SH3 domain
 IPR001609  Myosin head, motor domain
 IPR011993  PH-like domain superfamily
 IPR014352  FERM/acyl-CoA-binding protein superfamily
 IPR019748  FERM central domain
 IPR019749  Band 4.1 domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR029071  Ubiquitin-like domain superfamily
 IPR035963  FERM superfamily, second domain
 IPR036028  SH3-like domain superfamily
 IPR036106  Class VII myosin, motor domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007018 microtubule-based movement IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:1904970 brush border assembly IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005902 microvillus IEA
 cellular_componentGO:0005903 brush border IEA
 cellular_componentGO:0016459 myosin complex IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0090651 apical cytoplasm IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003774 motor activity IEA
 molecular_functionGO:0003777 microtubule motor activity IEA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008017 microtubule binding IEA
 molecular_functionGO:0051015 actin filament binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Myh1tm1b(KOMP)Wtsi/Myh1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Myh1tm1b(KOMP)Wtsi/J

 MP:0005633 increased circulating sodium level "greater than the normal concentration in the blood of this metallic element, the most plentiful extracellular ion in the body and the principal determinant of extracellular fluid volume" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Myh1tm1b(KOMP)Wtsi/Myh1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Myh1tm1b(KOMP)Wtsi/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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