MP:0000034 | abnormal vestibule morphology | "malformed cavity between the semicircular canals and the cochlea of the inner ear" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:1776] |
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Allelic Composition: Myo6mpc285H/Myo6mpc285H Genetic Background: involves: BALB/c * C3H/HeH * C57BL/6J
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MP:0000042 | abnormal organ of Corti | "abnormalities associated with the highly specialized epithelium in the floor of the ductus cochlearis; also referred to a spiral organ (organum spirale), or acoustic papilla" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Aprttm1Dwm/Aprttm1Dwm Genetic Background: 129P2/OlaHsd-Aprttm1Dwm
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MP:0000045 | abnormal hair cell morphology | "malformation of the sensory epithelial cells of the inner ear" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
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Allelic Composition: NhsXcat/Nhs+ Genetic Background: involves: DBA/2 * T STOCK
Allelic Composition: Myo7a3336SB/Myo7a3336SB Genetic Background: involves: BALB/cRl
Allelic Composition: Myo7a4494SB/Myo7a4494SB Genetic Background: involves: BALB/cRl
Allelic Composition: Myo7a816SB/Myo7a816SB Genetic Background: involves: BALB/cRl
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MP:0000436 | abnormal head movements | "anomalous motion of the portion of the body containing the brain and organs of sight, hearing, taste, and smell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Gcgrtm1Mjch/Gcgrtm1Mjch Genetic Background: involves: 129 * C57BL/6J * SJL
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MP:0001005 | abnormal rod morphology | "structural or developmental anomaly of the photoreceptors that contain rhodopsin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Dnah11b2b598Clo/Dnah11b2b598Clo Genetic Background: C57BL/6J-Dnah11b2b598Clo
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MP:0001265 | reduced body size | "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170] |
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Allelic Composition: Aprttm1Dwm/Aprttm1Dwm Genetic Background: 129P2/OlaHsd-Aprttm1Dwm
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MP:0001289 | persistence of hyaloid capillary system | "failure of the degeneration of the transient vascular system of the eye during development" [J:49840] |
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Allelic Composition: Myo7atm1a(EUCOMM)Wtsi/Myo7atm1a(EUCOMM)Wtsi Genetic Background: C57BL/6N-Myo7atm1a(EUCOMM)Wtsi/Wtsi
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MP:0001363 | increased anxiety-related response | "when compared to controls, subjects exhibit more responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:49752, J:53060] |
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Allelic Composition: Aprttm1Dwm/Aprttm1Dwm Genetic Background: 129P2/OlaHsd-Aprttm1Dwm
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MP:0001394 | circling | "repeated, compulsive movement in a circle; often associated with inner ear defects" [MGI:CLS, J:61295] |
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Allelic Composition: Aprttm1Dwm/Aprttm1Dwm Genetic Background: 129P2/OlaHsd-Aprttm1Dwm
Allelic Composition: Myo7ash1-7J/Myo7ash1-7J Genetic Background: STOCK Myo7ash1-7J/J
Allelic Composition: Myo7ash1-11J/Myo7ash1-11J Genetic Background: C57BL/6J-Myo7ash1-11J/J
Allelic Composition: Myo7ash1-9J/Myo7ash1-9J Genetic Background: involves: C3.MRL-Faslpr/J
Allelic Composition: Myo7ash1/Myo7ash1 Genetic Background: SH1/LeJ
Allelic Composition: Myo7apolka/Myo7apolka Genetic Background: involves: C57BL/6J
Allelic Composition: Myo7ash1-8J/Myo7ash1-8J Genetic Background: B6.Cg-Myo7ash1-8J/J
Allelic Composition: Myo7ash1-7J/Myo7ash1-8J Genetic Background: B6.Cg-Myo7ash1-7J Myo7ash1-8J
Allelic Composition: Myo7aewaso/Myo7aewaso Genetic Background: involves: C57BL/6J
Allelic Composition: Myo7am1Btlr/Myo7am1Btlr Genetic Background: C57BL/6J-Myo7am1Btlr
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MP:0001399 | hyperactivity | "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125] |
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Allelic Composition: Aprttm1Dwm/Aprttm1Dwm Genetic Background: 129P2/OlaHsd-Aprttm1Dwm
Allelic Composition: Myo7aHdb/Myo7aHdb Genetic Background: C3HeB/FeJ-Myo7aHdb/Ieg
Allelic Composition: Myo7aHdb/Myo7a+ Genetic Background: C3HeB/FeJ-Myo7aHdb/Ieg
Allelic Composition: Myo7am1Btlr/Myo7am1Btlr Genetic Background: C57BL/6J-Myo7am1Btlr
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MP:0001406 | abnormal gait | "unusual or distinctive way of walking" [J:65038] |
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Allelic Composition: Aprttm1Dwm/Aprttm1Dwm Genetic Background: 129P2/OlaHsd-Aprttm1Dwm
Allelic Composition: Myo7ash1-13J/Myo7ash1-13J Genetic Background: C.Cg-Myo7ash1-13J/GrsrJ
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MP:0001408 | stereotypic behavior | "repetitive, invariant, perseverative motor patterns that do not appear to be purposeful" [What s wrong with my mouse?:ISBN 0-471-31639-3] |
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Allelic Composition: Myo7atm1a(EUCOMM)Wtsi/Myo7atm1a(EUCOMM)Wtsi Genetic Background: C57BL/6N-Myo7atm1a(EUCOMM)Wtsi/Wtsi
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MP:0001410 | head bobbing | "compulsive up and down movement of the head" [J:17123] |
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Allelic Composition: Myo7aHdb/Myo7aHdb Genetic Background: C3HeB/FeJ-Myo7aHdb/Ieg
Allelic Composition: Myo7aHdb/Myo7a+ Genetic Background: C3HeB/FeJ-Myo7aHdb/Ieg
Allelic Composition: Myo7ash1-8J/Myo7ash1-8J Genetic Background: B6.Cg-Myo7ash1-8J/J
Allelic Composition: Myo7ash1-13J/Myo7ash1-13J Genetic Background: C.Cg-Myo7ash1-13J/GrsrJ
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MP:0001489 | decreased startle reflex | "greater threshold or less severe reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, What s Wrong With My Mouse?:ISBN 0-471-31639-3] |
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Allelic Composition: Myo7apolka/Myo7apolka Genetic Background: involves: C57BL/6J
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MP:0001512 | trunk curl | "posture of the trunk in a curled position" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator] |
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Allelic Composition: Adamts6b2b2029Clo/Adamts6b2b2029Clo Genetic Background: C57BL/6J-Adamts6b2b2029Clo
Allelic Composition: Myo7atm1a(EUCOMM)Wtsi/Myo7atm1a(EUCOMM)Wtsi Genetic Background: C57BL/6N-Myo7atm1a(EUCOMM)Wtsi/Wtsi
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MP:0001522 | impaired swimming | "reduced ability or inability to swim" [J:45446, J:39081] |
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Allelic Composition: Aprttm1Dwm/Aprttm1Dwm Genetic Background: 129P2/OlaHsd-Aprttm1Dwm
Allelic Composition: Myo7ash1-6J/Myo7ash1-6J Genetic Background: involves: C57BLKS/J
Allelic Composition: Myo7ash1/Myo7ash1 Genetic Background: SH1/LeJ
Allelic Composition: Myo7apolka/Myo7apolka Genetic Background: involves: C57BL/6J
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MP:0001523 | impaired righting response | "reduced ability or greater amount of time needed to recover from supine position" [J:25565] |
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Allelic Composition: Myo7atm1a(EUCOMM)Wtsi/Myo7atm1a(EUCOMM)Wtsi Genetic Background: C57BL/6N-Myo7atm1a(EUCOMM)Wtsi/Wtsi
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MP:0001525 | impaired balance | "reduced ability of an animal to maintain equilibrium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:64962, J:17123] |
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Allelic Composition: Leprdb-1R/Leprdb-1R Genetic Background: involves: D7R75M
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MP:0001922 | reduced male fertility | "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340] |
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Allelic Composition: Aprttm1Dwm/Aprttm1Dwm Genetic Background: 129P2/OlaHsd-Aprttm1Dwm
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MP:0001925 | male infertility | "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409] |
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Allelic Composition: Myo7ash1-6J/Myo7ash1-6J Genetic Background: involves: C57BLKS/J
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MP:0001963 | abnormal hearing | "anomaly in the ability to receive auditory stimuli" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: NhsXcat/Nhs+ Genetic Background: involves: DBA/2 * T STOCK
Allelic Composition: Myo7a3336SB/Myo7a3336SB Genetic Background: involves: BALB/cRl
Allelic Composition: Myo7a4494SB/Myo7a4494SB Genetic Background: involves: BALB/cRl
Allelic Composition: Myo7a816SB/Myo7a816SB Genetic Background: involves: BALB/cRl
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MP:0001967 | deafness | "inability to hear" [J:57651] |
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Allelic Composition: Aprttm1Dwm/Aprttm1Dwm Genetic Background: 129P2/OlaHsd-Aprttm1Dwm
Allelic Composition: Myo7ash1-6J/Myo7ash1-6J Genetic Background: involves: C57BLKS/J
Allelic Composition: Myo7ash1-7J/Myo7ash1-7J Genetic Background: STOCK Myo7ash1-7J/J
Allelic Composition: Myo7ash1-9J/Myo7ash1-9J Genetic Background: involves: C3.MRL-Faslpr/J
Allelic Composition: Cdh23v/Cdh23+,Myo7ash1/Myo7a+ Genetic Background: involves: BALB
Allelic Composition: Myo7ampc142H/Myo7ampc142H Genetic Background: involves: BALB/c * C3H/HeH * C57BL/6J
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MP:0002068 | abnormal parental behavior | "altered behavior of animals towards offspring" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Hrrh/Hrrh Genetic Background: RHJ/LeJ
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MP:0002183 | gliosis | "increased growth pattern of neuroglia in a damaged area of the brain or spinal cord" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Aprttm1Dwm/Aprttm1Dwm Genetic Background: 129P2/OlaHsd-Aprttm1Dwm
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MP:0002622 | abnormal cochlear hair cell morphology | "malformation of the sensory epithelial cells of the cochlea; these cells are in synaptic contact with the auditory nerve" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Aprttm1Dwm/Aprttm1Dwm Genetic Background: 129P2/OlaHsd-Aprttm1Dwm
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MP:0002730 | head shaking | "compulsive movement of the head in the horizontal plane" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:274] |
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Allelic Composition: Myo7ash1-7J/Myo7ash1-7J Genetic Background: STOCK Myo7ash1-7J/J
Allelic Composition: Myo7ash1-13J/Myo7ash1-13J Genetic Background: C.Cg-Myo7ash1-13J/GrsrJ
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MP:0002857 | cochlear ganglion degeneration | "loss of neural cell bodies in the group of nerve cell bodies that conveys auditory sensation from the organ of Corti to the hindbrain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Aprttm1Dwm/Aprttm1Dwm Genetic Background: 129P2/OlaHsd-Aprttm1Dwm
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MP:0003382 | straub tail | "condition in which an animal carries its tail in an erect (vertical or nearly vertical) position; often seen upon opioid and other drug treatment" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Myo7ash1-13J/Myo7ash1-13J Genetic Background: C.Cg-Myo7ash1-13J/GrsrJ
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MP:0003878 | abnormal ear physiology | "anomolous function of the ear, not due to an anatomical defect" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:100987] |
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Allelic Composition: Aprttm1Dwm/Aprttm1Dwm Genetic Background: 129P2/OlaHsd-Aprttm1Dwm
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MP:0003961 | decreased lean body mass | "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator] |
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Allelic Composition: Myo7atm1a(EUCOMM)Wtsi/Myo7atm1a(EUCOMM)Wtsi Genetic Background: C57BL/6N-Myo7atm1a(EUCOMM)Wtsi/Wtsi
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MP:0004331 | saccular macula degeneration | "degeneration or loss of the oval neuroepithelial sensory receptor in the anterior wall of the saccule" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Aprttm1Dwm/Aprttm1Dwm Genetic Background: 129P2/OlaHsd-Aprttm1Dwm
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MP:0004362 | cochlear hair cell degeneration | "degeneration or loss of the sensory epithelial cells of the cochlea; these cells are in synaptic contact with the auditory nerve" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Aprttm1Dwm/Aprttm1Dwm Genetic Background: 129P2/OlaHsd-Aprttm1Dwm
Allelic Composition: Myo7aewaso/Myo7aewaso Genetic Background: involves: C57BL/6J
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MP:0004363 | stria vascularis degeneration | "degeneration or loss of the stratified, secretory epithelium which lines the upper part of the cochlear spiral ligament and maintains potassium ion homeostasis in the endolymph" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Aprttm1Dwm/Aprttm1Dwm Genetic Background: 129P2/OlaHsd-Aprttm1Dwm
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MP:0004399 | abnormal cochlear outer hair cell morphology | "any structural abnormality in the sensory cells of the organ of Corti which are in synaptic contact with sensory as well as efferent fibers of the auditory nerve; there are three rows of columnar outer hair cells largely surrounded by cortilymph and supporting phalangeal cells; the apical end of each cell is anchored to the cuticular plate and about 100 stereocilia arranged in a V-shaped pattern extend from the cell s surface through the cuticular plate into the tectorial membrane" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Meox2tm1(cre)Sor/0,Pcsk5tm2Prat/Pcsk5tm2.1Prat Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * SJL
Allelic Composition: Myo7aewaso/Myo7aewaso Genetic Background: involves: C57BL/6J
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MP:0004402 | decreased cochlear outer hair cell number | "decreased number (or less than the expected 3 rows) of the columnar outer hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Cdh23v/Cdh23+ Genetic Background: involves: BALB/cRl * 47BS/Rl * CBA/Ca
Allelic Composition: Cdh23v/Cdh23+,Myo7a4626SB/Myo7a+ Genetic Background: involves: BALB/cRl * 47BS/Rl * CBA/Ca
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MP:0004404 | cochlear outer hair cell degeneration | "degeneration or loss of the columnar outer hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Meox2tm1(cre)Sor/0,Pcsk5tm2Prat/Pcsk5tm2.1Prat Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * SJL
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MP:0004413 | absent cochlear microphonics | "absence or loss of the bioelectric potentials produced by the hair cells of the organ of Corti in response to sound" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Myo7a816SB/Myo7a816SB Genetic Background: involves: BALB/cRl
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MP:0004415 | abnormal cochlear nerve compound action potential | "anomaly in the combined potentials resulting from activation of the auditory division of the eighth cranial nerve; these potentials represent the summed activity of multiple cochlear afferent fibers discharging synchronously and thus assess the combined functional state of OHCs, IHCs, and their primary afferent innervation" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Cdh23v/Cdh23+ Genetic Background: involves: BALB/cRl * 47BS/Rl * CBA/Ca
Allelic Composition: Cdh23v/Cdh23+,Myo7a4626SB/Myo7a+ Genetic Background: involves: BALB/cRl * 47BS/Rl * CBA/Ca
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MP:0004466 | short cochlear outer hair cells | |
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Allelic Composition: Meox2tm1(cre)Sor/0,Pcsk5tm2Prat/Pcsk5tm2.1Prat Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * SJL
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MP:0004491 | abnormal orientation of outer hair cell stereociliary bundles | "misorientation or rotation of outer hair cell (OHC) stereociliary bundles, resulting in defective planar cell polarity of the inner ear sensory epithelium " [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Pex11atm1Itl/Pex11atm1Itl Genetic Background: C57BL/6-Pex11atm1Itl
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MP:0004492 | abnormal orientation of inner hair cell stereociliary bundles | "misorientation or rotation of inner hair cell (IHC) stereociliary bundles, resulting in defective planar cell polarity of the inner ear sensory epithelium" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Myo7aewaso/Myo7aewaso Genetic Background: involves: C57BL/6J
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MP:0004515 | abnormal vestibular hair cell stereociliary bundle morphology | "any structural anomaly or disruption of the typical staircase-like arrangement of the mechanosensitive hair bundles which are composed of thick long microvilli (stereocilia) and are located at the apical end of vestibular hair cells of the utricle and saccule" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Myo7aHdb/Myo7a+ Genetic Background: C3HeB/FeJ-Myo7aHdb/Ieg
Allelic Composition: Myo7ash1-8J/Myo7ash1-8J Genetic Background: B6.Cg-Myo7ash1-8J/J
Allelic Composition: Myo7aewaso/Myo7aewaso Genetic Background: involves: C57BL/6J
Allelic Composition: Myo7admbo2/Myo7admbo2 Genetic Background: involves: C57BL/6J
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MP:0004517 | decreased vestibular hair cell stereocilia number | "decreased number of the nonmotile, actin-filled specialized microvilli (stereocilia) normally arrayed on vestibular hair cells in a staircase-like pattern" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Myo7aewaso/Myo7aewaso Genetic Background: involves: C57BL/6J
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MP:0004521 | abnormal cochlear hair cell stereociliary bundle morphology | "any structural anomaly or disruption of the typical pattern of arrangement of mechanosensitive hair bundles which are composed of thick long microvilli (stereocilia) and are located at the apical end of cochlear inner and outer hair cells" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Myo7a816SB/Myo7a816SB Genetic Background: involves: BALB/cRl
Allelic Composition: Myo7apolka/Myo7apolka Genetic Background: involves: C57BL/6J
Allelic Composition: Myo7a4626SB/Myo7a4626SB Genetic Background: involves: 129S7/SvEvBrd * BALB/cRl * C3H * C57BL/6J * CBA/Ca
Allelic Composition: Myo7ash1-8J/Myo7ash1-8J Genetic Background: B6.Cg-Myo7ash1-8J/J
Allelic Composition: Myo7admbo2/Myo7admbo2 Genetic Background: involves: C57BL/6J
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MP:0004522 | abnormal orientation of cochlear hair cell stereociliary bundles | "misorientation or rotation of inner and/or outer hair cell stereociliary bundles, resulting in defective planar cell polarity of the inner ear sensory epithelium" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Myo7a816SB/Myo7a816SB Genetic Background: involves: BALB/cRl
Allelic Composition: Myo7a4626SB/Myo7a4626SB Genetic Background: involves: BALB/cRl
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MP:0004524 | short cochlear hair cell stereocilia | "reduced length of the nonmotile, actin-filled specialized microvilli (stereocilia) which are normally arrayed on cochlear inner and outer hair cells" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Myo7apolka/Myo7apolka Genetic Background: involves: C57BL/6J
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MP:0004527 | abnormal outer hair cell stereociliary bundle morphology | "any structural anomaly or disruption of the typical V or W-like pattern of arrangement of mechanosensitive hair bundles located at the apical end of cochlear OHCs; each hair bundle is normally composed of ~100 nonmotile, actin-filled microvilli (stereocilia) arranged in rows of increasing height and coupled to one another by morphologically distinct links: tip links, horizontal top connectors, shaft connectors, and ankle links; most hair bundles also possess a single motile kinocilium immediately adjacent to the tallest (outermost) row of stereocilia; a fifth link type, the kinocilial link, connects the kinocilium to its neighboring stereocilia" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Myo7aHdb/Myo7aHdb Genetic Background: C3HeB/FeJ-Myo7aHdb/Ieg
Allelic Composition: Myo7aHdb/Myo7a+ Genetic Background: C3HeB/FeJ-Myo7aHdb/Ieg
Allelic Composition: Myo7aHdb/Myo7a4626SB Genetic Background: involves: BALB/c * 47BS/Rl * C3HeB/FeJ * CBA/Ca
Allelic Composition: Myo7a4626SB/Myo7a4626SB Genetic Background: involves: BALB/cRl * 47BS/Rl * C3Hf/Rl * C57BL/10Rl * CBA/Ca
Allelic Composition: Cdh23v/Cdh23v,Myo7a4626SB/Myo7a+ Genetic Background: mixed
Allelic Composition: Cdh23v/Cdh23+,Myo7a4626SB/Myo7a4626SB Genetic Background: mixed
Allelic Composition: Cdh23v/Cdh23v,Myo7a4626SB/Myo7a4626SB Genetic Background: mixed
Allelic Composition: Myo7a4626SB/Myo7a+ Genetic Background: involves: BALB/cRl * 47BS/Rl * CBA/Ca
Allelic Composition: Cdh23v/Cdh23+,Myo7a4626SB/Myo7a+ Genetic Background: involves: BALB/cRl * 47BS/Rl * CBA/Ca
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MP:0004529 | decreased outer hair cell stereocilia number | "decreased number (or less than the expected 100 or so) of the nonmotile, actin-filled specialized microvilli (stereocilia) normally arrayed on cochlear outer hair cells" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Myo7aHdb/Myo7aHdb Genetic Background: C3HeB/FeJ-Myo7aHdb/Ieg
Allelic Composition: Myo7a4626SB/Myo7a+ Genetic Background: involves: BALB/cRl * 47BS/Rl * CBA/Ca
Allelic Composition: Cdh23v/Cdh23+,Myo7a4626SB/Myo7a+ Genetic Background: involves: BALB/cRl * 47BS/Rl * CBA/Ca
Allelic Composition: Myo7aewaso/Myo7aewaso Genetic Background: involves: C57BL/6J
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MP:0004532 | abnormal inner hair cell stereociliary bundle morphology | "any structural anomaly or disruption of the typically linear or U-shaped pattern of arrangement of mechanosensitive hair bundles located at the apical end of cochlear IHCs; each hair bundle is normally composed of ~100 nonmotile, actin-filled microvilli (stereocilia) arranged in rows of increasing height and coupled to one another by morphologically distinct links: tip links, horizontal top connectors, shaft connectors, and ankle links; most hair bundles also possess a single motile kinocilium immediately adjacent to the tallest row of stereocilia; a fifth link type, the kinocilial link, connects the kinocilium to its neighboring stereocilia" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Myo7aHdb/Myo7aHdb Genetic Background: C3HeB/FeJ-Myo7aHdb/Ieg
Allelic Composition: Myo7aHdb/Myo7a+ Genetic Background: C3HeB/FeJ-Myo7aHdb/Ieg
Allelic Composition: Myo7aHdb/Myo7a4626SB Genetic Background: involves: BALB/c * 47BS/Rl * C3HeB/FeJ * CBA/Ca
Allelic Composition: Myo7a4626SB/Myo7a4626SB Genetic Background: involves: BALB/cRl
Allelic Composition: Myo7aewaso/Myo7aewaso Genetic Background: involves: C57BL/6J
Allelic Composition: Myo7admbo2/Myo7admbo2 Genetic Background: involves: C57BL/6J
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MP:0004533 | fused inner hair cell stereocilia | "coalescence of the nonmotile, actin-filled specialized microvilli (stereocilia) normally arrayed on cochlear inner hair cells, often resulting in giant stereocilia" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Myo7aHdb/Myo7aHdb Genetic Background: C3HeB/FeJ-Myo7aHdb/Ieg
Allelic Composition: Myo7aHdb/Myo7a+ Genetic Background: C3HeB/FeJ-Myo7aHdb/Ieg
Allelic Composition: Myo7aHdb/Myo7a4626SB Genetic Background: involves: BALB/c * 47BS/Rl * C3HeB/FeJ * CBA/Ca
Allelic Composition: Myo7aewaso/Myo7aewaso Genetic Background: involves: C57BL/6J
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MP:0004534 | decreased inner hair cell stereocilia number | "decreased number (or less than the expected 100 or so) of the nonmotile, actin-filled specialized microvilli (stereocilia) normally arrayed on cochlear inner hair cells" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Myo7aHdb/Myo7aHdb Genetic Background: C3HeB/FeJ-Myo7aHdb/Ieg
Allelic Composition: Myo7aewaso/Myo7aewaso Genetic Background: involves: C57BL/6J
Allelic Composition: Myo7admbo2/Myo7admbo2 Genetic Background: involves: C57BL/6J
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MP:0004577 | abnormal cochlear hair cell inter-stereocilial links | "any structural abnormality in the morphologically and biochemically distinct link types that extend between the stereocilia of cochlear hair bundles; link types can be distinguished by their relative sensitivities to treatment with calcium chelators and the protease subtilisin; in the mature mouse cochlea, tip links and horizontal top connectors are the only inter-stereocilial links associated with the hair bundle; ankle links and transient lateral links are both prominent features of developing auditory hair bundles" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Myo7a4626SB/Myo7a4626SB Genetic Background: involves: BALB/cRl
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MP:0004582 | absent cochlear hair bundle ankle links | "absence of the long, single-stranded filaments that form a dense web or mesh around the base of cochlear hair bundles just above the region in which the stereocilia begin to taper down" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Myo7a4626SB/Myo7a4626SB Genetic Background: involves: BALB/cRl
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MP:0004598 | abnormal cochlear basement membrane | "any structural abnormality in the continuous basement membrane found within the membranous labyrinth of the cochlea, known to extend from the limbus, down to the inner sulcus, across the basilar membrane, up to the external sulcus to the spiral prominence and radiating into the spiral ligament enseathing the root cell processes" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Myo7aewaso/Myo7aewaso Genetic Background: involves: C57BL/6J
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MP:0004632 | abnormal cochlear OHC efferent innervation | "any changes in the morphology or number of efferent terminals, occurring as clusters, in the cochlear OHC region; normally, medial olivocochlear neurons, which are primarily found in rostral and ventral periolivary regions, project mainly to the contralateral cochlea, and terminate directly on OHCs" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Aprttm1Dwm/Aprttm1Dwm Genetic Background: 129P2/OlaHsd-Aprttm1Dwm
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MP:0004737 | absent distortion product otoacoustic emissions | "failure to create mechanical distortions in the inner ear when two primary tones are presented, indicating failure of outer hair cells to amplify basilar membrane motion" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Myo7apolka/Myo7apolka Genetic Background: involves: C57BL/6J
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MP:0004748 | increased susceptibility to age-related hearing loss | "greater than normal loss of hearing associated with advancing age, manifest as reduced ability to perceive or discriminate sounds; the pattern and age of onset vary" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Cdh23v-2J/Cdh23+ Genetic Background: mixed
Allelic Composition: Cdh23v-2J/Cdh23+,Myo7a4626SB/Myo7a+ Genetic Background: mixed
Allelic Composition: Myo7a4626SB/Myo7a+ Genetic Background: involves: BALB/cRl * 47BS/Rl * CBA/Ca
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MP:0004767 | increased cochlear nerve compound action potential | "greater combined potentials resulting from activation of the auditory division of the eighth cranial nerve" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Myo7aHdb/Myo7aHdb Genetic Background: C3HeB/FeJ-Myo7aHdb/Ieg
Allelic Composition: Myo7aHdb/Myo7a+ Genetic Background: C3HeB/FeJ-Myo7aHdb/Ieg
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MP:0004813 | absent linear vestibular evoked potential | "absence of the biphasic response elicited by linear acceleration transients (usually jerk pulses to an animal s head)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Myo7ash1/Myo7ash1 Genetic Background: SH1/LeJ
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MP:0004924 | abnormal behavior | "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Aprttm1Dwm/Aprttm1Dwm Genetic Background: 129P2/OlaHsd-Aprttm1Dwm
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MP:0005191 | head tilt | "condition in which the portion of the body containing the brain and organs of sight, hearing, taste, and smell lists to the side" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Myo7ash1-7J/Myo7ash1-7J Genetic Background: STOCK Myo7ash1-7J/J
Allelic Composition: Myo7ash1-11J/Myo7ash1-11J Genetic Background: C57BL/6J-Myo7ash1-11J/J
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MP:0005201 | abnormal retinal pigment epithelium morphology | "anomaly in the epithelial layer of the retina composed of cells containing pigment granules " [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Myo7apolka/Myo7apolka Genetic Background: involves: C57BL/6J
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MP:0005307 | head tossing | "compulsive flailing of the head in multiple directions" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Aprttm1Dwm/Aprttm1Dwm Genetic Background: 129P2/OlaHsd-Aprttm1Dwm
Allelic Composition: Myo7ash1-6J/Myo7ash1-6J Genetic Background: involves: C57BLKS/J
Allelic Composition: Myo7ash1-13J/Myo7ash1-13J Genetic Background: C.Cg-Myo7ash1-13J/GrsrJ
Allelic Composition: Myo7am1Btlr/Myo7am1Btlr Genetic Background: C57BL/6J-Myo7am1Btlr
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MP:0005424 | jerky movement | "continuous, abrupt, faltering motions of the whole body or a portion of the body" [llw2:Linda Washburn , Mouse Genome Informatics Curator] |
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Allelic Composition: Aprttm1Dwm/Aprttm1Dwm Genetic Background: 129P2/OlaHsd-Aprttm1Dwm
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MP:0005551 | abnormal eye electrophysiology | "abnormal function of the eye as determined through electrophysiological recordings from single cells or summary recordings from multiple cells (e.g. electroretinogram)" [NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator] |
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Allelic Composition: Cdh23v/Cdh23v Genetic Background: involves: CBA/Ca
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MP:0005565 | increased blood urea nitrogen level | "high circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Myo7atm1a(EUCOMM)Wtsi/Myo7atm1a(EUCOMM)Wtsi Genetic Background: C57BL/6N-Myo7atm1a(EUCOMM)Wtsi/Wtsi
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MP:0005633 | increased circulating sodium level | "greater than the normal concentration in the blood of this metallic element, the most plentiful extracellular ion in the body and the principal determinant of extracellular fluid volume" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission] |
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Allelic Composition: Myo7atm1a(EUCOMM)Wtsi/Myo7atm1a(EUCOMM)Wtsi Genetic Background: C57BL/6N-Myo7atm1a(EUCOMM)Wtsi/Wtsi
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MP:0006325 | impaired hearing | "reduced ability to percieve auditory stimuli" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Myo7a4626SB/Myo7a+ Genetic Background: involves: BALB/cRl * 47BS/Rl * CBA/Ca
Allelic Composition: Myo7ash1-8J/Myo7a+ Genetic Background: B6.Cg-Myo7ash1-8J/J
Allelic Composition: Myo7aewaso/Myo7aewaso Genetic Background: involves: C57BL/6J
Allelic Composition: Myo7admbo2/Myo7admbo2 Genetic Background: involves: C57BL/6J
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MP:0006358 | absent pinna reflex | "complete failure to respond to an auditory stimulus by a characteristic ear twitch" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Aprttm1Dwm/Aprttm1Dwm Genetic Background: 129P2/OlaHsd-Aprttm1Dwm
Allelic Composition: Cdh23v/Cdh23+,Myo7a4626SB/Myo7a+ Genetic Background: mixed
Allelic Composition: Cdh23v-2J/Cdh23+,Myo7a4626SB/Myo7a+ Genetic Background: mixed
Allelic Composition: Myo7atm1a(EUCOMM)Wtsi/Myo7atm1a(EUCOMM)Wtsi Genetic Background: C57BL/6N-Myo7atm1a(EUCOMM)Wtsi/Wtsi
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MP:0006359 | absent startle reflex | "failure to respond to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Myo7ash1-7J/Myo7ash1-8J Genetic Background: B6.Cg-Myo7ash1-7J Myo7ash1-8J
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MP:0006388 | abnormal auditory summating potiential | "any anomaly in the dc shift in the waveform sustained for the duration of a toneburst stimulus that represents the depolarization of sensory hair cells in the cochlea; positive summating potentials (SPs) reflect activity of basal turn hair cells while negative SPs are derived from hair cell activity in the apical turn; negative SPs tend to be obtained at low frequencies and low intensities of stimulus, while positive SPs are recorded in response to high frequencies and high intensities " [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:1526886] |
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Allelic Composition: Myo7a816SB/Myo7a816SB Genetic Background: involves: BALB/cRl
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MP:0006409 | vestibular ganglion hypoplasia | "underdevelopment or reduced size, usually due to a reduced number of cell bodies, in the group of bipolar sensory nerve cell bodies concerned with equilibration that form a swelling on the vestibular part of the eighth cranial nerve in the fundus of the internal acoustic meatus" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Aprttm1Dwm/Aprttm1Dwm Genetic Background: 129P2/OlaHsd-Aprttm1Dwm
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MP:0008039 | increased NK T cell number | "greater number of the distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments" [GO:0001865] |
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Allelic Composition: Myo7atm1a(EUCOMM)Wtsi/Myo7atm1a(EUCOMM)Wtsi Genetic Background: C57BL/6N-Myo7atm1a(EUCOMM)Wtsi/Wtsi
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MP:0008451 | retinal rod cell degeneration | "a retrogressive impairment of function or destruction of one of the photoreceptor cell types of the vertebrate retina, in which the photopigment is in stacks of membranous disks separate from the outer cell membrane" [MESH:A08.663.650.650.670.650] |
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Allelic Composition: Dnah11b2b598Clo/Dnah11b2b598Clo Genetic Background: C57BL/6J-Dnah11b2b598Clo
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MP:0008489 | postnatal slow weight gain | "the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Aprttm1Dwm/Aprttm1Dwm Genetic Background: 129P2/OlaHsd-Aprttm1Dwm
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MP:0010323 | retropulsion | "a tendency to step or walk backwards" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Myo7ash1-6J/Myo7ash1-6J Genetic Background: involves: C57BLKS/J
Allelic Composition: Myo7ash1-13J/Myo7ash1-13J Genetic Background: C.Cg-Myo7ash1-13J/GrsrJ
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MP:0011939 | increased food intake | "increase in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith] |
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Allelic Composition: Aprttm1Dwm/Aprttm1Dwm Genetic Background: 129P2/OlaHsd-Aprttm1Dwm
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MP:0011941 | increased fluid intake | "increase in the total amount of fluid taken in over time when compared to the normal state" [MGI:csmith] |
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Allelic Composition: Aprttm1Dwm/Aprttm1Dwm Genetic Background: 129P2/OlaHsd-Aprttm1Dwm
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MP:0011967 | increased or absent threshold for auditory brainstem response | "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith] |
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Allelic Composition: Myo7apolka/Myo7apolka Genetic Background: involves: C57BL/6J
Allelic Composition: Myo7ash1-8J/Myo7ash1-8J Genetic Background: B6.Cg-Myo7ash1-8J/J
Allelic Composition: Myo7ash1-8J/Myo7a+,Ush1gjs/Ush1g+ Genetic Background: B6.Cg-Myo7ash1-8J Ush1gjs
Allelic Composition: Cdh23v-2J/Cdh23+,Myo7ash1-8J/Myo7a+ Genetic Background: B6.Cg-Myo7ash1-8J Cdh23v-2J
Allelic Composition: Myo7ash1-8J/Myo7a+,Pcdh15av-3J/Pcdh15+ Genetic Background: B6.Cg-Myo7ash1-8J Pcdh15av-3J
Allelic Composition: Myo7aewaso/Myo7aewaso Genetic Background: involves: C57BL/6J
Allelic Composition: Myo7aewaso/Myo7a+ Genetic Background: involves: C57BL/6J
Allelic Composition: Myo7admbo2/Myo7admbo2 Genetic Background: involves: C57BL/6J
Allelic Composition: Myo7atm1a(EUCOMM)Wtsi/Myo7atm1a(EUCOMM)Wtsi Genetic Background: C57BL/6N-Myo7atm1a(EUCOMM)Wtsi/Wtsi
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