ENSDARG00000099871


Danio rerio

Features
Gene ID: ENSDARG00000099871
  
Biological name :myo7aa
  
Synonyms : myo7aa / myosin VIIAa
  
Possible biological names infered from orthology : MYO7A / myosin VIIA / P97479 / Q13402 / Unconventional myosin-VIIa
  
Species: Danio rerio
  
Chr. number: 18
Strand: -1
Band:
Gene start: 3367779
Gene end: 3473081
  
Corresponding Affymetrix probe sets: Dr.10454.1.S1_at (Zebrafish Array)   NM_152983_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000134410
Ensembl peptide - ENSDARP00000143601
Ensembl peptide - ENSDARP00000135754
NCBI entrez gene - 252846     See in Manteia.
RefSeq - NM_152983
RefSeq - XM_021467573
RefSeq Peptide - NP_694515
swissprot - A0A286Y9F5
swissprot - Q9DGG8
swissprot - A0A0R4IM58
ZFIN ID - ZDB-GENE-020709-1
Ensembl - ENSDARG00000099871
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 MYO7AENSGALG00000031450Gallus gallus
 MYO7AENSG00000137474Homo sapiens
 Myo7aENSMUSG00000030761Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
myo7ab / myosin VIIAb / MYO7A* / P97479* / Q13402* / myosin VIIA* / Unconventional myosin-VIIa *ENSDARG0000004463282
si:ch73-194h10.2 / MYO7B* / Q6PIF6* / Q99MZ6* / myosin VIIB* / Unconventional myosin-VIIb *ENSDARG0000004444154
myo7bb / myosin VIIBb / MYO7B* / Q6PIF6* / Q99MZ6* / myosin VIIB* / Unconventional myosin-VIIb *ENSDARG0000007720149
myo10 / myosin X / F8VQB6* / Q9HD67* / Mus musculus myosin X (Myo10), transcript variant 3, mRNA.*ENSDARG0000001700425
myo10l1 / myosin X-like 1ENSDARG0000007472324
myo5aa / myosin VAa / MYO5A* / Q99104* / Q9Y4I1* / myosin VA* / Unconventional myosin-Va *ENSDARG0000006163521
myo5ab / myosin VAb / MYO5A* / Q99104* / Q9Y4I1* / myosin VA* / Unconventional myosin-Va *ENSDARG0000002521820
myo9aa / myosin IXAa / MYO9A* / B2RTY4* / myosin IXA*ENSDARG0000007672920
myo5b / myosin VB / Q9ULV0* / AC090227.1*ENSDARG0000006200320
myo5c / myosin VC / Q9NQX4*ENSDARG0000010423520
MYO9B / si:zfos-588f8.1 / Q13459* / myosin IXB*ENSDARG0000007831319
myo9b / myosin IXb / Q13459*ENSDARG0000007741018
myo9ab / myosin IXAb / MYO9A* / Q8C170* / B2RTY4* / myosin IXA* / Unconventional myosin-IXa *ENSDARG0000007384318
myo6b / myosin VIb / MYO6* / Q9UM54* / myosin VI*ENSDARG0000004214115
myo6a / myosin VIa / MYO6* / Q9UM54* / myosin VI*ENSDARG0000004401615
mbd3b / si:dkey-110c1.10ENSDARG0000006181015
myo10l3 / myosin X-like 3ENSDARG0000007414313


Protein motifs (from Interpro)
Interpro ID Name
 IPR000048  IQ motif, EF-hand binding site
 IPR000299  FERM domain
 IPR000857  MyTH4 domain
 IPR001452  SH3 domain
 IPR001609  Myosin head, motor domain
 IPR011993  PH-like domain superfamily
 IPR014352  FERM/acyl-CoA-binding protein superfamily
 IPR019748  FERM central domain
 IPR019749  Band 4.1 domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR029071  Ubiquitin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006897 endocytosis IMP
 biological_processGO:0007018 microtubule-based movement IEA
 biological_processGO:0007423 sensory organ development IMP
 biological_processGO:0035315 hair cell differentiation IMP
 biological_processGO:0050974 detection of mechanical stimulus involved in sensory perception IMP
 biological_processGO:0060122 inner ear receptor cell stereocilium organization IMP
 biological_processGO:0061512 protein localization to cilium IMP
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0016459 myosin complex IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003774 motor activity IEA
 molecular_functionGO:0003777 microtubule motor activity IEA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008017 microtubule binding IEA
 molecular_functionGO:0051015 actin filament binding IEA


Pathways (from Reactome)
Pathway description
The canonical retinoid cycle in rods (twilight vision)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000144 retinal pigmented epithelium retinal pigmented epithelium cell death increased process quality , abnormal
Show

 ZFA:0000168 anterior macula anterior macula stereocilium bundle bent , abnormal
anterior macula stereocilium bundle splayed , abnormal
Show

 ZFA:0000678 hair cell anterior macula hair cell anterior macula stereocilium decreased amount , abnormal
Show

 ZFA:0001094 whole organism whole organism unbalanced , abnormal
whole organism decreased behavioural activity , abnormal
whole organism circling , abnormal
whole organism shape , abnormal
Show

 ZFA:0001464 retinal outer nuclear layer retinal outer nuclear layer apoptotic process increased process quality , abnormal
retinal outer nuclear layer cell death increased process quality , abnormal
Show

 ZFA:0009121 auditory receptor cell auditory receptor cell stereocilium bundle splayed , abnormal
auditory receptor cell stereocilium bundle shape , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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