ENSMUSG00000025885


Mus musculus

Features
Gene ID: ENSMUSG00000025885
  
Biological name :Myo5b
  
Synonyms : Myo5b / myosin VB
  
Possible biological names infered from orthology : Q9ULV0
  
Species: Mus musculus
  
Chr. number: 18
Strand: 1
Band: E2
Gene start: 74440936
Gene end: 74771493
  
Corresponding Affymetrix probe sets: 10456653 (MoGene1.0st)   1437698_at (Mouse Genome 430 2.0 Array)   1441104_at (Mouse Genome 430 2.0 Array)   1452298_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000073790
Ensembl peptide - ENSMUSP00000112728
Ensembl peptide - ENSMUSP00000123123
Ensembl peptide - ENSMUSP00000135825
NCBI entrez gene - 17919     See in Manteia.
MGI - MGI:106598
RefSeq - XM_006525716
RefSeq - NM_201600
RefSeq - XM_006525714
RefSeq - XM_006525715
RefSeq Peptide - NP_963894
swissprot - D3Z135
swissprot - G5E8G6
swissprot - H3BLK6
swissprot - G3X9Y9
Ensembl - ENSMUSG00000025885
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 myo5bENSDARG00000062003Danio rerio
 ENSGALG00000012984Gallus gallus
 MYO5BENSG00000167306Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Myo5a / Q99104 / Unconventional myosin-Va / Q9Y4I1* / myosin VA*ENSMUSG0000003459362
Myo5c / myosin VC / Q9NQX4*ENSMUSG0000003359049
Myo7a / P97479 / Unconventional myosin-VIIa / Q13402* / myosin VIIA*ENSMUSG0000003076124
Myo9a / Q8C170 / Unconventional myosin-IXa / B2RTY4* / myosin IXA*ENSMUSG0000003958523
Myo7b / Q99MZ6 / Unconventional myosin-VIIb / Q6PIF6* / myosin VIIB*ENSMUSG0000002438823
Myo9b / myosin IXB / Q13459*ENSMUSG0000000467722
Myo10 / F8VQB6 / Mus musculus myosin X (Myo10), transcript variant 3, mRNA. / Q9HD67* / myosin X*ENSMUSG0000002227221
Myo6 / myosin VI / Q9UM54*ENSMUSG0000003357719


Protein motifs (from Interpro)
Interpro ID Name
 IPR000048  IQ motif, EF-hand binding site
 IPR001609  Myosin head, motor domain
 IPR002710  Dilute domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR036103  Class V myosin, motor domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007018 microtubule-based movement IEA
 biological_processGO:0016192 vesicle-mediated transport IEA
 biological_processGO:0016197 endosomal transport IEA
 cellular_componentGO:0016459 myosin complex IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 cellular_componentGO:0045179 apical cortex IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003774 motor activity IEA
 molecular_functionGO:0003777 microtubule motor activity IEA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008017 microtubule binding IEA
 molecular_functionGO:0017137 Rab GTPase binding IEA
 molecular_functionGO:0051015 actin filament binding IEA


Pathways (from Reactome)
Pathway description
Vasopressin regulates renal water homeostasis via Aquaporins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000189 hypoglycemia "low levels of plasma glucose in the circulating blood; this generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: GarsC201R/Gars+,Tg(Thy1-YFP)16Jrs/?
Genetic Background: involves: BALB/cAnN * C3H/HeH * C57BL/6J * CBA

 MP:0000479 abnormal intestinal cell "anomalous structure or development of the cells comprising the intestine" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: GarsC201R/Gars+,Tg(Thy1-YFP)16Jrs/?
Genetic Background: involves: BALB/cAnN * C3H/HeH * C57BL/6J * CBA

Allelic Composition: Myo5btm1.1Cle/Myo5btm1.1Cle,Tg(Vil-cre/ERT2)23Syr/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * DBA/2

 MP:0000488 abnormal intestinal epithelium morphology "anomalous structure or development of the cellular avascular layer of the digestive tube passing from the stomach to the anus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: GarsC201R/Gars+,Tg(Thy1-YFP)16Jrs/?
Genetic Background: involves: BALB/cAnN * C3H/HeH * C57BL/6J * CBA

Allelic Composition: Myo5btm1.1Cle/Myo5btm1.1Cle,Tg(Vil-cre/ERT2)23Syr/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * DBA/2

 MP:0001211 wrinkled skin "irregular folds and/or indentations on the skin" [J:19212]
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Allelic Composition: GarsC201R/Gars+,Tg(Thy1-YFP)16Jrs/?
Genetic Background: involves: BALB/cAnN * C3H/HeH * C57BL/6J * CBA

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: GarsC201R/Gars+,Tg(Thy1-YFP)16Jrs/?
Genetic Background: involves: BALB/cAnN * C3H/HeH * C57BL/6J * CBA

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
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Allelic Composition: Efna1tm1a(EUCOMM)Wtsi/Efna1tm1a(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0001429 dehydration "excessive water loss from the body or from an organ or bodily part" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:50053]
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Allelic Composition: Efna1tm1a(EUCOMM)Wtsi/Efna1tm1a(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0005036 diarrhea "abnormally frequent discharge of semi-solid or fluid fecal matter from the bowel" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: GarsC201R/Gars+,Tg(Thy1-YFP)16Jrs/?
Genetic Background: involves: BALB/cAnN * C3H/HeH * C57BL/6J * CBA

Allelic Composition: Myo5btm1.1Cle/Myo5btm1.1Cle,Tg(Vil-cre/ERT2)23Syr/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * DBA/2

 MP:0008108 abnormal small intestinal villus morphology "any structural anomaly of the tiny hair-like projections that protrude from the inside of the small intestine that contain blood vessels that capture digested nutrients that are absorbed through the intestinal wall; the villi increase the absorptive surface area of the small intestine by approximately 30-fold" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Myo5btm1.1Cle/Myo5btm1.1Cle,Tg(Vil-cre/ERT2)23Syr/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * DBA/2

 MP:0008109 abnormal small intestinal microvillus morphology "any structural anomaly of the additional extensions of the villi of the small intestine which protrude from the apical surface of the epithelial cells lining the villi; the microvilli increase the absorptive surface area of the small intestine by approximately 600-fold" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: GarsC201R/Gars+,Tg(Thy1-YFP)16Jrs/?
Genetic Background: involves: BALB/cAnN * C3H/HeH * C57BL/6J * CBA

Allelic Composition: Myo5btm1.1Cle/Myo5btm1.1Cle,Tg(Vil-cre/ERT2)23Syr/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * DBA/2

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
Show

Allelic Composition: GarsC201R/Gars+,Tg(Thy1-YFP)16Jrs/?
Genetic Background: involves: BALB/cAnN * C3H/HeH * C57BL/6J * CBA

 MP:0014078 small intestinal villus atrophy "erosion or abnormal flattening of the surface secondary to the shortening and blunting of the small intestinal villi; villus atrophy is a non-specific reaction of the intestinal mucosa to a variety of injuries; the pathogenesis is either associated with a hyper-regenerative increase in crypt cell mitoses leading to crypt elongation or it results from hyporegeneration, that is, reduced mitotic rate with shortened crypts" [MGI:Anna, PMID:16679353]
Show

Allelic Composition: Myo5btm1.1Cle/Myo5btm1.1Cle,Tg(Vil-cre/ERT2)23Syr/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * DBA/2

 MP:0014080 fused small intestinal villi "partial or complete fusion of the tiny hair-like projections which protrude from the inside of the small intestine and contain blood vessels that capture digested nutrients that are absorbed through the intestinal wall" [MGI:Anna, PMID:16679353]
Show

Allelic Composition: Myo5btm1.1Cle/Myo5btm1.1Cle,Tg(Vil-cre/ERT2)23Syr/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * DBA/2

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000004771 P62492 / Rab11a / RAB11A, member RAS oncogene family / P62491*  / complex
 ENSMUSG00000040022 G3XA57 / Rab11fip2 / RAB11 family interacting protein 2 (class I) / Q7L804* / RAB11 family interacting protein 2*  / complex






 

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