ENSGALG00000041121


Gallus gallus

Features
Gene ID: ENSGALG00000041121
  
Biological name :SLIT2
  
Synonyms : SLIT2 / slit homolog 2 protein precursor
  
Possible biological names infered from orthology : O94813 / Q9R1B9 / slit guidance ligand 2
  
Species: Gallus gallus
  
Chr. number: 4
Strand: -1
Band:
Gene start: 75487239
Gene end: 75766552
  
Corresponding Affymetrix probe sets: Gga.909.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000045198
Ensembl peptide - ENSGALP00000052436
Ensembl peptide - ENSGALP00000050197
Ensembl peptide - ENSGALP00000048398
Ensembl peptide - ENSGALP00000046258
Ensembl peptide - ENSGALP00000045864
NCBI entrez gene - 373967     See in Manteia.
RefSeq - NM_001267075
RefSeq - XM_015285716
RefSeq Peptide - NP_001254004
swissprot - A0A1D5P0S9
swissprot - A0A1D5PI04
swissprot - A0A1D5NXU8
swissprot - A0A1D5NZP6
swissprot - A0A1D5PBR7
swissprot - A0A1D5P6R8
Ensembl - ENSGALG00000041121
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 slit2ENSDARG00000004246Danio rerio
 SLIT2ENSG00000145147Homo sapiens
 Slit2ENSMUSG00000031558Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
SLIT1 / slit homolog 1 protein precursor / Q80TR4* / O75093* / slit guidance ligand 1* / Slit homolog 1 protein *ENSGALG0000004287167
SLIT3 / slit guidance ligand 3 / O75094* / Q9WVB4* / Slit homolog 3 protein *ENSGALG0000000191666
CRB2 / crumbs 2, cell polarity complex component / 2 * / Q5IJ48* / Q80YA8*ENSGALG0000000116914
DNER / delta/notch like EGF repeat containing / Q8JZM4* / Q8NFT8* / Delta and Notch-like epidermal growth factor-related receptor *ENSGALG0000000295810
CRB1 / crumbs 1, cell polarity complex component / 1 * / P82279* / Q8VHS2*ENSGALG000000022877
DLK2 / delta like non-canonical Notch ligand 2 / 2 * / Q6UY11* / Q8K1E3*ENSGALG000000103866
DLK1 / delta like non-canonical Notch ligand 1 / P80370*ENSGALG000000112446


Protein motifs (from Interpro)
Interpro ID Name
 IPR000152  EGF-type aspartate/asparagine hydroxylation site
 IPR000372  Leucine-rich repeat N-terminal domain
 IPR000483  Cysteine-rich flanking region, C-terminal
 IPR000742  EGF-like domain
 IPR001611  Leucine-rich repeat
 IPR001791  Laminin G domain
 IPR001881  EGF-like calcium-binding domain
 IPR003591  Leucine-rich repeat, typical subtype
 IPR003645  Follistatin-like, N-terminal
 IPR006207  Cystine knot, C-terminal
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR013032  EGF-like, conserved site
 IPR013320  Concanavalin A-like lectin/glucanase domain superfamily
 IPR018097  EGF-like calcium-binding, conserved site
 IPR032675  Leucine-rich repeat domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001657 ureteric bud development IEA
 biological_processGO:0001933 negative regulation of protein phosphorylation IEA
 biological_processGO:0002042 cell migration involved in sprouting angiogenesis IEA
 biological_processGO:0002689 negative regulation of leukocyte chemotaxis IEA
 biological_processGO:0007411 axon guidance IEA
 biological_processGO:0008045 motor neuron axon guidance IEA
 biological_processGO:0010593 negative regulation of lamellipodium assembly IEA
 biological_processGO:0010596 negative regulation of endothelial cell migration IEA
 biological_processGO:0014912 negative regulation of smooth muscle cell migration IEA
 biological_processGO:0021836 chemorepulsion involved in postnatal olfactory bulb interneuron migration IEA
 biological_processGO:0021972 corticospinal neuron axon guidance through spinal cord IEA
 biological_processGO:0030308 negative regulation of cell growth IEA
 biological_processGO:0030336 negative regulation of cell migration IEA
 biological_processGO:0030837 negative regulation of actin filament polymerization IEA
 biological_processGO:0031290 retinal ganglion cell axon guidance IEA
 biological_processGO:0032870 cellular response to hormone stimulus IEA
 biological_processGO:0035385 Roundabout signaling pathway IEA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0043116 negative regulation of vascular permeability IEA
 biological_processGO:0048754 branching morphogenesis of an epithelial tube IEA
 biological_processGO:0048846 axon extension involved in axon guidance IEA
 biological_processGO:0050919 negative chemotaxis IEA
 biological_processGO:0050929 induction of negative chemotaxis IEA
 biological_processGO:0051058 negative regulation of small GTPase mediated signal transduction IEA
 biological_processGO:0051414 response to cortisol IEA
 biological_processGO:0061364 apoptotic process involved in luteolysis IEA
 biological_processGO:0070100 negative regulation of chemokine-mediated signaling pathway IEA
 biological_processGO:0071504 cellular response to heparin IEA
 biological_processGO:0071672 negative regulation of smooth muscle cell chemotaxis IEA
 biological_processGO:0071676 negative regulation of mononuclear cell migration IEA
 biological_processGO:0090024 negative regulation of neutrophil chemotaxis IEA
 biological_processGO:0090260 negative regulation of retinal ganglion cell axon guidance IEA
 biological_processGO:0090288 negative regulation of cellular response to growth factor stimulus IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0005095 GTPase inhibitor activity IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0008201 heparin binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0043237 laminin-1 binding IEA
 molecular_functionGO:0043394 proteoglycan binding IEA
 molecular_functionGO:0048495 Roundabout binding IEA


Pathways (from Reactome)
Pathway description
Signaling by ROBO receptors
Role of ABL in ROBO-SLIT signaling
SLIT2:ROBO1 increases RHOA activity
Regulation of expression of SLITs and ROBOs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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