ENSDARG00000016153


Danio rerio

Features
Gene ID: ENSDARG00000016153
  
Biological name :dag1
  
Synonyms : dag1 / dystroglycan 1
  
Possible biological names infered from orthology : Dystroglycan Alpha-dystroglycan Beta-dystroglycan / Q14118 / Q62165
  
Species: Danio rerio
  
Chr. number: 22
Strand: 1
Band:
Gene start: 33131891
Gene end: 33194802
  
Corresponding Affymetrix probe sets: Dr.21837.1.A1_at (Zebrafish Array)   Dr.4988.1.S1_at (Zebrafish Array)   NM_173274_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000020759
Ensembl peptide - ENSDARP00000106371
NCBI entrez gene - 286829     See in Manteia.
RefSeq - NM_173274
RefSeq - XM_005170544
RefSeq - XM_009296487
RefSeq Peptide - NP_775381
swissprot - F1QMH7
ZFIN ID - ZDB-GENE-021223-1
Ensembl - ENSDARG00000016153
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 DAG1ENSGALG00000037784Gallus gallus
 DAG1ENSG00000173402Homo sapiens
 Dag1ENSMUSG00000039952Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR006644  Dystroglycan-type cadherin-like
 IPR008465  Dystroglycan
 IPR013783  Immunoglobulin-like fold
 IPR015919  Cadherin-like
 IPR027468  Alpha-dystroglycan domain 2
 IPR030398  DG-type SEA domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007016 cytoskeletal anchoring at plasma membrane IEA
 biological_processGO:0007519 skeletal muscle tissue development IMP
 biological_processGO:0007525 somatic muscle development IMP
 biological_processGO:0016203 muscle attachment IMP
 biological_processGO:0033292 T-tubule organization IMP
 biological_processGO:0043113 receptor clustering IGI
 biological_processGO:0048741 skeletal muscle fiber development IMP
 biological_processGO:0048747 muscle fiber development IMP
 cellular_componentGO:0016010 dystrophin-associated glycoprotein complex IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0042383 sarcolemma IDA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0043236 laminin binding IDA


Pathways (from Reactome)
Pathway description
ECM proteoglycans
O-linked glycosylation
Regulation of expression of SLITs and ROBOs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000014 dorsal aorta dorsal aorta intersegmental vessel separated from dorsal longitudinal anastomotic vessel , abnormal
Show

 ZFA:0000035 lens lens malformed , abnormal
Show

 ZFA:0000076 swim bladder swim bladder absent , abnormal
Show

 ZFA:0000152 retina retina malformed , abnormal
Show

 ZFA:0000155 somite somite myoseptum deformed , abnormal
somite intersegmental vessel absent , abnormal
somite intersegmental vessel disorganized , abnormal
Show

 ZFA:0000358 granular layer corpus cerebelli granular layer corpus cerebelli disorganized , abnormal
Show

 ZFA:0000445 optic tectum optic tectum disorganized , abnormal
Show

 ZFA:0000473 trunk musculature trunk musculature dystrophic , abnormal
trunk musculature skeletal muscle cell retracted , abnormal
Show

 ZFA:0000610 vertical myoseptum vertical myoseptum deformed , abnormal
vertical myoseptum increased width , abnormal
vertical myoseptum malformed , abnormal
vertical myoseptum physical object quality , abnormal
vertical myoseptum basement membrane irregular spatial pattern , abnormal
Show

 ZFA:0000640 cornea cornea absent , abnormal
Show

 ZFA:0001056 myotome myotome refractivity , abnormal
myotome skeletal muscle degenerate , abnormal
myotome muscle cell detached from myotome muscle tendon junction, abnormal
myotome basement membrane morphology , ameliorated
myotome basement membrane malformed , abnormal
myotome muscle cell attached to myotome muscle tendon junction, ameliorated
myotome muscle tendon junction malformed , abnormal
myotome muscle tendon junction disorganized , abnormal
Show

 ZFA:0001058 caudal fin caudal fin kinked , abnormal
Show

 ZFA:0001069 ventral fin fold ventral fin fold decreased size , abnormal
Show

 ZFA:0001089 myoseptum myoseptum broken , abnormal
Show

 ZFA:0001094 whole organism whole organism dead , abnormal
whole organism decreased speed , abnormal
whole organism dystrophic , abnormal
Show

 ZFA:0001117 post-vent region post-vent region decreased length , abnormal
post-vent region increased curvature , abnormal
post-vent region muscle cell morphology , abnormal
Show

 ZFA:0005145 muscle muscle damaged , abnormal
muscle dystrophic , abnormal
muscle morphology , abnormal
muscle necrotic , abnormal
muscle disorganized , abnormal
muscle sarcoplasmic reticulum unstructured , abnormal
muscle sarcomere morphology , abnormal
muscle sarcomere decreased amount , abnormal
Show

 ZFA:0005277 skeletal muscle skeletal muscle dystrophic , abnormal
Show

 ZFA:0009114 muscle cell muscle cell detached from muscle cell , abnormal
muscle cell detached from vertical myoseptum , abnormal
Show

 ZFA:0009115 skeletal muscle cell skeletal muscle cell detached from myoseptum , abnormal
skeletal muscle cell terminal cisterna malformed , abnormal
skeletal muscle cell T-tubule malformed , abnormal
skeletal muscle cell sarcolemma separated from skeletal muscle cell sarcolemma, abnormal
Show

 ZFA:0009116 slow muscle cell slow muscle cell detached from myoseptum , abnormal
Show

 ZFA:0009117 fast muscle cell fast muscle cell detached from myoseptum , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000016153 dag1 / dystroglycan 1 / Q14118* / Q62165* / Dystroglycan Alpha-dystroglycan Beta-dystroglycan*  / complex
 ENSDARG00000004246 slit2 / slit homolog 2 (Drosophila) / O94813* / Q9R1B9* / slit guidance ligand 2*  / reaction / complex
 ENSDARG00000052025 pomgnt1 / protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-) / Q8WZA1* / Q91X88* / Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1 *  / reaction
 ENSDARG00000055027 pomt2 / F1Q8R9 / protein-O-mannosyltransferase 2 / Q9UKY4* / Q8BGQ4* / Protein O-mannosyl-transferase 2 *  / reaction
 ENSDARG00000003208 pomk / Q5U3W1 / protein-O-mannose kinase / Q3TUA9* / Q9H5K3*  / reaction
 ENSDARG00000067670 pomt1 / F1QF89 / protein-O-mannosyltransferase 1 / Q9Y6A1* / Q8R2R1* / Protein O-mannosyl-transferase 1 *  / reaction
 ENSDARG00000010941 Q5NDE5 / pomgnt2 / protein O-linked mannose N-acetylglucosaminyltransferase 2 (beta 1,4-) / Q8NAT1*  / reaction






 

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