ENSDARG00000060081


Danio rerio

Features
Gene ID: ENSDARG00000060081
  
Biological name :crb2b
  
Synonyms : crb2b / crumbs family member 2b
  
Possible biological names infered from orthology : 2 / CRB2 / crumbs 2, cell polarity complex component / Q5IJ48 / Q80YA8
  
Species: Danio rerio
  
Chr. number: 8
Strand: 1
Band:
Gene start: 2878756
Gene end: 2906214
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000132145
swissprot - A0A0R4IBP9
ZFIN ID - ZDB-GENE-060610-1
Ensembl - ENSDARG00000060081
  
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CRB2ENSGALG00000001169Gallus gallus
 CRB2ENSG00000148204Homo sapiens
 2 ENSMUSG00000035403Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
crb2a / crumbs family member 2a / 2 * / CRB2* / Q5IJ48* / Q80YA8* / crumbs 2, cell polarity complex component*ENSDARG0000006010647
crb1 / crumbs family member 1, photoreceptor morphogenesis associated / 1 * / P82279* / Q8VHS2* / crumbs 1, cell polarity complex component*ENSDARG0000010050633
slit1b / slit homolog 1b (Drosophila) / SLIT1* / Q80TR4* / O75093* / slit guidance ligand 1* / Slit homolog 1 protein *ENSDARG0000009944614
slit1a / slit homolog 1a (Drosophila) / SLIT1* / Q80TR4* / O75093* / slit guidance ligand 1* / Slit homolog 1 protein *ENSDARG0000004495414
slit2 / slit homolog 2 (Drosophila) / O94813* / Q9R1B9* / slit guidance ligand 2*ENSDARG0000000424614
slit3 / slit homolog 3 (Drosophila) / Q9WVB4* / O75094* / slit guidance ligand 3* / Slit homolog 3 protein *ENSDARG0000003426813
dner / delta/notch-like EGF repeat containing / Q8NFT8*ENSDARG0000006103111
CR456624.1 / DLL3* / O88516* / Q9NYJ7* / Delta-like protein 3 * / delta like canonical Notch ligand 3*ENSDARG000000795197
dlk2 / delta-like 2 homolog (Drosophila) / 2 * / Q6UY11* / Q8K1E3* / delta like non-canonical Notch ligand 2*ENSDARG000000762476
CABZ01102109.1 / DLK1* / P80370* / delta like non-canonical Notch ligand 1*ENSDARG000001142264


Protein motifs (from Interpro)
Interpro ID Name
 IPR000152  EGF-type aspartate/asparagine hydroxylation site
 IPR000742  EGF-like domain
 IPR001791  Laminin G domain
 IPR001881  EGF-like calcium-binding domain
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR013032  EGF-like, conserved site
 IPR013320  Concanavalin A-like lectin/glucanase domain superfamily
 IPR018097  EGF-like calcium-binding, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003094 glomerular filtration IMP
 biological_processGO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules IPI
 biological_processGO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IPI
 biological_processGO:0032835 glomerulus development IMP
 biological_processGO:0036060 slit diaphragm assembly IMP
 biological_processGO:0042462 eye photoreceptor cell development IMP
 biological_processGO:0045197 establishment or maintenance of epithelial cell apical/basal polarity IGI
 biological_processGO:0048793 pronephros development IMP
 biological_processGO:0060042 retina morphogenesis in camera-type eye IMP
 biological_processGO:0060271 cilium assembly IMP
 biological_processGO:0072015 glomerular visceral epithelial cell development IMP
 biological_processGO:0072104 glomerular capillary formation IMP
 biological_processGO:0098609 cell-cell adhesion IDA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005509 calcium ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000054 pericardium pericardium edematous , abnormal
Show

 ZFA:0000107 eye eye decreased size , abnormal
Show

 ZFA:0000151 pronephros pronephros cystic , abnormal
Show

 ZFA:0000166 lateral crista lateral crista cilium increased length , abnormal
Show

 ZFA:0000554 olfactory epithelium olfactory epithelium cilium increased length , abnormal
Show

 ZFA:0001288 renal glomerulus renal glomerulus disorganized , abnormal
Show

 ZFA:0001557 pronephric glomerulus pronephric glomerulus cystic , abnormal
pronephric glomerulus permeability , abnormal
pronephric glomerulus slit diaphragm decreased amount , abnormal
pronephric glomerulus physical object quality , abnormal
Show

 ZFA:0001673 pronephric podocyte pronephric podocyte morphology , abnormal
pronephric podocyte cell projection disorganized , abnormal
Show

 ZFA:0005284 glomerular capillary glomerular capillary fused with glomerular capillary , abnormal
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 ZFA:0009285 podocyte podocyte attached to pronephric glomerulus , abnormal
podocyte apical plasma membrane protruding into pronephric capsular space , abnormal
podocyte slit diaphragm morphology , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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