ENSMUSG00000021365


Mus musculus

Features
Gene ID: ENSMUSG00000021365
  
Biological name :Nedd9
  
Synonyms : Nedd9 / neural precursor cell expressed, developmentally down-regulated gene 9 / O35177
  
Possible biological names infered from orthology : neural precursor cell expressed, developmentally down-regulated 9 / Q14511
  
Species: Mus musculus
  
Chr. number: 13
Strand: -1
Band: A4
Gene start: 41309581
Gene end: 41487362
  
Corresponding Affymetrix probe sets: 10408850 (MoGene1.0st)   1422818_at (Mouse Genome 430 2.0 Array)   1437132_x_at (Mouse Genome 430 2.0 Array)   1447885_x_at (Mouse Genome 430 2.0 Array)   1450767_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000125773
Ensembl peptide - ENSMUSP00000152937
Ensembl peptide - ENSMUSP00000021794
NCBI entrez gene - 18003     See in Manteia.
MGI - MGI:97302
RefSeq - NM_017464
RefSeq - XM_006516874
RefSeq - NM_001111324
RefSeq Peptide - NP_001104794
RefSeq Peptide - NP_059492
swissprot - A0A0R4J212
swissprot - O35177
swissprot - A0A286YCE4
Ensembl - ENSMUSG00000021365
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nedd9ENSDARG00000089878Danio rerio
 NEDD9ENSGALG00000012747Gallus gallus
 NEDD9ENSG00000111859Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Bcar1 / Q61140 / Breast cancer anti-estrogen resistance protein 1 / P56945* / BCAR1, Cas family scaffolding protein*ENSMUSG0000003195541
Cass4 / Q08EC4 / Cas scaffolding protein family member 4 / Q9NQ75*ENSMUSG0000007457024
Efs / Q64355 / Embryonal Fyn-associated substrate / O43281*ENSMUSG0000002220321


Protein motifs (from Interpro)
Interpro ID Name
 IPR001452  SH3 domain
 IPR014928  Serine rich protein interaction domain
 IPR021901  CAS family, C-terminal
 IPR035746  Enhancer of filamentation 1, SH3 domain
 IPR036028  SH3-like domain superfamily
 IPR037362  CAS family


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0040008 regulation of growth IEA
 biological_processGO:0051301 cell division IEA
 cellular_componentGO:0000922 spindle pole IDA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005938 cell cortex IEA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000694 spleen hypoplasia "small size due to reduced cell number in the spleen" [J:43971]
Show

Allelic Composition: Eif4ebp1tm1Pjb/Eif4ebp1tm1Pjb
Genetic Background: involves: 129P2/OlaHsd

 MP:0002444 abnormal T cell physiology "anomalous response of T lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Eif4ebp1tm1Pjb/Eif4ebp1tm1Pjb
Genetic Background: involves: 129P2/OlaHsd

 MP:0002458 abnormal B cell number "deviation from the normal number of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Eif4ebp1tm1Pjb/Eif4ebp1tm1Pjb
Genetic Background: involves: 129P2/OlaHsd

 MP:0003156 abnormal lymphocyte migration/homing "altered ability of blood lymphocytes to bind to high endothelial venules (HEV), tether and roll along the luminal aspects of HEV, and migrate into the lymph nodes" [acv:Alicia C. Valenzuela, Mouse Genome Informatics Curator, J:92231]
Show

Allelic Composition: Eif4ebp1tm1Pjb/Eif4ebp1tm1Pjb
Genetic Background: involves: 129P2/OlaHsd

 MP:0005016 decreased lymphocyte number "fewer than normal white blood cell numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Eif4ebp1tm1Pjb/Eif4ebp1tm1Pjb
Genetic Background: involves: 129P2/OlaHsd

 MP:0008101 lymph node hypoplasia "underdevelopment or reduced size, usually due to a reduced cell number, in the lymph nodes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Eif4ebp1tm1Pjb/Eif4ebp1tm1Pjb
Genetic Background: involves: 129P2/OlaHsd

 MP:0008143 abnormal dendrite morphology "any structural anomaly of the highly branched tree-like process of a neuron that serves as a receptive field and conducts impulses toward the cell body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cfap69tm1c(KOMP)Wtsi/Cfap69tm1c(KOMP)Wtsi,Omptm4(cre)Mom/Omp+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6N

 MP:0008173 increased follicular B cell number "greater number of resting mature B cells with distinct phenotypic characteristics (CD23-positive, CD21-positive) found typically in the B cell follicle region of the spleen and lymph nodes" [CL:0000843, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Eif4ebp1tm1Pjb/Eif4ebp1tm1Pjb
Genetic Background: involves: 129P2/OlaHsd

 MP:0008182 decreased marginal zone B cell number "reduced number of CD23-negative, CD21-positive B cells of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL" [CL:0000845, ISBN:0781735149]
Show

Allelic Composition: Eif4ebp1tm1Pjb/Eif4ebp1tm1Pjb
Genetic Background: involves: 129P2/OlaHsd

 MP:0008191 abnormal follicular B cell physiology "abnormal function of a resting mature B cell with distinct phenotypic characteristics (CD23-positive, CD21-positive) found typically in the B cell follicle region of the spleen" [CL:0000843, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Eif4ebp1tm1Pjb/Eif4ebp1tm1Pjb
Genetic Background: involves: 129P2/OlaHsd

 MP:0009936 abnormal dendritic spine morphology "any structural anomaly of the small membranous protrusion from the dendrite of a neuron that is involved in synaptic transmission; it typically receives input from a single synapse of an axon" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cfap69tm1c(KOMP)Wtsi/Cfap69tm1c(KOMP)Wtsi,Omptm4(cre)Mom/Omp+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6N

 MP:0009938 abnormal hippocampus granule cell morphology "any structural anomaly of the small neurons of the hippocampal granule cell layer" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cfap69tm1c(KOMP)Wtsi/Cfap69tm1c(KOMP)Wtsi,Omptm4(cre)Mom/Omp+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6N

 MP:0012307 impaired spatial learning "impaired ability to ascertain or acquire spatial location information in order to improve navigation or other behavior using such location cues" [MGI:csmith]
Show

Allelic Composition: Cfap69tm1c(KOMP)Wtsi/Cfap69tm1c(KOMP)Wtsi,Omptm4(cre)Mom/Omp+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6N

 MP:0020335 abnormal dentate gyrus neuron dendrite morphology "any structural anomaly of the highly branched tree-like process of a neuron in one of two interlocking gyri of the hippocampus formation" [ORCID: orcid.org/0000-0003-4606-0597]
Show

Allelic Composition: Cfap69tm1c(KOMP)Wtsi/Cfap69tm1c(KOMP)Wtsi,Omptm4(cre)Mom/Omp+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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