ENSMUSG00000022203


Mus musculus

Features
Gene ID: ENSMUSG00000022203
  
Biological name :Efs
  
Synonyms : Efs / Embryonal Fyn-associated substrate / Q64355
  
Possible biological names infered from orthology : O43281
  
Species: Mus musculus
  
Chr. number: 14
Strand: -1
Band: C2
Gene start: 54916535
Gene end: 54926126
  
Corresponding Affymetrix probe sets: 10419892 (MoGene1.0st)   1416716_at (Mouse Genome 430 2.0 Array)   1438114_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000022813
Ensembl peptide - ENSMUSP00000154047
Ensembl peptide - ENSMUSP00000154657
NCBI entrez gene - 13644     See in Manteia.
MGI - MGI:105311
RefSeq - XM_006518518
RefSeq - NM_010112
RefSeq - XM_006518516
RefSeq Peptide - NP_034242
swissprot - Q64355
Ensembl - ENSMUSG00000022203
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 efsENSDARG00000088835Danio rerio
 EFSENSG00000100842Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Bcar1 / Q61140 / Breast cancer anti-estrogen resistance protein 1 / P56945* / BCAR1, Cas family scaffolding protein*ENSMUSG0000003195536
Nedd9 / O35177 / neural precursor cell expressed, developmentally down-regulated gene 9 / Q14511* / neural precursor cell expressed, developmentally down-regulated 9*ENSMUSG0000002136531
Cass4 / Q08EC4 / Cas scaffolding protein family member 4 / Q9NQ75*ENSMUSG0000007457019


Protein motifs (from Interpro)
Interpro ID Name
 IPR001452  SH3 domain
 IPR021901  CAS family, C-terminal
 IPR035747  Embryonal Fyn-associated substrate, SH3 domain
 IPR036028  SH3-like domain superfamily
 IPR037362  CAS family


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007155 cell adhesion IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0017124 SH3 domain binding IDA
 molecular_functionGO:0019904 protein domain specific binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001846 increased inflammatory response "greater than expected response to injury, infection, or insult " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Abcb1atm1Bor/Abcb1atm1Bor
Genetic Background: FVBTac.129P2-Abcb1atm1Bor

Allelic Composition: Efstm1Kale/Efs+
Genetic Background: either: (involves: 129X1/SvJ) or (involves: 129X1/SvJ * C57BL/6J)

 MP:0001859 kidney inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Abcb1atm1Bor/Abcb1atm1Bor
Genetic Background: FVBTac.129P2-Abcb1atm1Bor

 MP:0001860 liver inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Abcb1atm1Bor/Abcb1atm1Bor
Genetic Background: FVBTac.129P2-Abcb1atm1Bor

 MP:0001861 lung inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Abcb1atm1Bor/Abcb1atm1Bor
Genetic Background: FVBTac.129P2-Abcb1atm1Bor

 MP:0002444 abnormal T cell physiology "anomalous response of T lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Abcb1atm1Bor/Abcb1atm1Bor
Genetic Background: FVBTac.129P2-Abcb1atm1Bor

 MP:0002461 increased circulating immunoglobulin concentration "greater than normal immunoglobulin level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Abcb1atm1Bor/Abcb1atm1Bor
Genetic Background: FVBTac.129P2-Abcb1atm1Bor

 MP:0002493 increased IgG "greater than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Abcb1atm1Bor/Abcb1atm1Bor
Genetic Background: FVBTac.129P2-Abcb1atm1Bor

Allelic Composition: Efstm1Kale/Efs+
Genetic Background: either: (involves: 129X1/SvJ) or (involves: 129X1/SvJ * C57BL/6J)

 MP:0002495 increased IgA "greater than normal immunoglobulin class A level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Abcb1atm1Bor/Abcb1atm1Bor
Genetic Background: FVBTac.129P2-Abcb1atm1Bor

Allelic Composition: Efstm1Kale/Efs+
Genetic Background: either: (involves: 129X1/SvJ) or (involves: 129X1/SvJ * C57BL/6J)

 MP:0003306 small intestinal inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the small intestine" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Abcb1atm1Bor/Abcb1atm1Bor
Genetic Background: FVBTac.129P2-Abcb1atm1Bor

Allelic Composition: Efstm1Kale/Efs+
Genetic Background: either: (involves: 129X1/SvJ) or (involves: 129X1/SvJ * C57BL/6J)

 MP:0008566 increased interferon-gamma secretion "increase in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
Show

Allelic Composition: Abcb1atm1Bor/Abcb1atm1Bor
Genetic Background: FVBTac.129P2-Abcb1atm1Bor

 MP:0008568 abnormal interleukin secretion "anomaly in the production or cellular release of soluble factors which stimulate growth-related activities of leukocytes and other cell types, that can act to enhance cell proliferation and differentiation, DNA synthesis, secretion of other biologically active molecules and responses to immune and inflammatory stimuli" [MESH:D12.644.276.374.465]
Show

Allelic Composition: Abcb1atm1Bor/Abcb1atm1Bor
Genetic Background: FVBTac.129P2-Abcb1atm1Bor

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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