7057


Homo sapiens (NCBI)

Features
Gene ID: 7057
  
Biological name :
  
Synonyms : THBS1 / THBS|THBS-1|TSP|TSP-1|TSP1 / thrombospondin 1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens (NCBI)
  
Chr. number:
Strand:
Band:
Gene start:
Gene end:
  
Corresponding Affymetrix probe sets: 201107_s_at (Human Genome U133 Plus 2.0 Array)   201108_s_at (Human Genome U133 Plus 2.0 Array)   201109_s_at (Human Genome U133 Plus 2.0 Array)   201110_s_at (Human Genome U133 Plus 2.0 Array)   215775_at (Human Genome U133 Plus 2.0 Array)   235086_at (Human Genome U133 Plus 2.0 Array)   239336_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: RefSeq - 767985152
RefSeq - XP_011520273.1
RefSeq - NC_000015.10
RefSeq - 40317626
RefSeq - NP_003237.2
RefSeq - NM_003246.3
RefSeq - XM_011521971.2
  
See co-cited genes in PubMed
Warning: Please see the Ensembl gene model ENSG00000137801 to get all the annotations available for this gene.


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000187 activation of MAPK activity IMP
 biological_processGO:0001666 response to hypoxia NAS
 biological_processGO:0001937 negative regulation of endothelial cell proliferation IMP
 biological_processGO:0001953 negative regulation of cell-matrix adhesion IDA
 biological_processGO:0002040 sprouting angiogenesis IMP
 biological_processGO:0002544 chronic inflammatory response IEP
 biological_processGO:0002576 platelet degranulation TAS
 biological_processGO:0002581 negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II IDA
 biological_processGO:0002605 negative regulation of dendritic cell antigen processing and presentation IDA
 biological_processGO:0006954 inflammatory response IDA
 biological_processGO:0006955 immune response IEP
 biological_processGO:0006986 response to unfolded protein IEA
 biological_processGO:0007050 cell cycle arrest IDA
 biological_processGO:0007155 cell adhesion NAS
 biological_processGO:0008284 positive regulation of cell proliferation IDA
 biological_processGO:0009612 response to mechanical stimulus IEA
 biological_processGO:0009749 response to glucose IDA
 biological_processGO:0010595 positive regulation of endothelial cell migration IDA
 biological_processGO:0010596 negative regulation of endothelial cell migration IDA
 biological_processGO:0010748 negative regulation of plasma membrane long-chain fatty acid transport IDA
 biological_processGO:0010751 negative regulation of nitric oxide mediated signal transduction IDA
 biological_processGO:0010754 negative regulation of cGMP-mediated signaling IDA
 biological_processGO:0010757 negative regulation of plasminogen activation IDA
 biological_processGO:0010759 positive regulation of macrophage chemotaxis ISS
 biological_processGO:0010763 positive regulation of fibroblast migration IDA
 biological_processGO:0016477 cell migration IDA
 biological_processGO:0016525 negative regulation of angiogenesis IMP
 biological_processGO:0018149 peptide cross-linking IDA
 biological_processGO:0030194 positive regulation of blood coagulation IDA
 biological_processGO:0030198 extracellular matrix organization TAS
 biological_processGO:0030335 positive regulation of cell migration IMP
 biological_processGO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway IDA
 biological_processGO:0032026 response to magnesium ion IDA
 biological_processGO:0032570 response to progesterone TAS
 biological_processGO:0032695 negative regulation of interleukin-12 production IDA
 biological_processGO:0032914 positive regulation of transforming growth factor beta1 production ISS
 biological_processGO:0033574 response to testosterone IEA
 biological_processGO:0034605 cellular response to heat NAS
 biological_processGO:0034976 response to endoplasmic reticulum stress ISS
 biological_processGO:0040037 negative regulation of fibroblast growth factor receptor signaling pathway IDA
 biological_processGO:0042327 positive regulation of phosphorylation IMP
 biological_processGO:0042493 response to drug IEP
 biological_processGO:0042535 positive regulation of tumor necrosis factor biosynthetic process IDA
 biological_processGO:0043032 positive regulation of macrophage activation IDA
 biological_processGO:0043066 negative regulation of apoptotic process IDA
 biological_processGO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IDA
 biological_processGO:0043536 positive regulation of blood vessel endothelial cell migration IDA
 biological_processGO:0043537 negative regulation of blood vessel endothelial cell migration IDA
 biological_processGO:0043652 engulfment of apoptotic cell IDA
 biological_processGO:0045652 regulation of megakaryocyte differentiation TAS
 biological_processGO:0045727 positive regulation of translation IDA
 biological_processGO:0045766 positive regulation of angiogenesis IMP
 biological_processGO:0048266 behavioral response to pain ISS
 biological_processGO:0048661 positive regulation of smooth muscle cell proliferation IDA
 biological_processGO:0050921 positive regulation of chemotaxis IDA
 biological_processGO:0051592 response to calcium ion IDA
 biological_processGO:0051895 negative regulation of focal adhesion assembly TAS
 biological_processGO:0051897 positive regulation of protein kinase B signaling IDA
 biological_processGO:0051918 negative regulation of fibrinolysis IDA
 biological_processGO:0071356 cellular response to tumor necrosis factor IEA
 biological_processGO:0071363 cellular response to growth factor stimulus IEA
 biological_processGO:0090051 negative regulation of cell migration involved in sprouting angiogenesis IMP
 biological_processGO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors IDA
 biological_processGO:1903588 negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis IMP
 biological_processGO:1903671 negative regulation of sprouting angiogenesis IGI
 biological_processGO:2000353 positive regulation of endothelial cell apoptotic process IDA
 biological_processGO:2000379 positive regulation of reactive oxygen species metabolic process IDA
 biological_processGO:2001027 negative regulation of endothelial cell chemotaxis IDA
 biological_processGO:2001237 negative regulation of extrinsic apoptotic signaling pathway TAS
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005577 fibrinogen complex IDA
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0005783 endoplasmic reticulum ISS
 cellular_componentGO:0005788 endoplasmic reticulum lumen TAS
 cellular_componentGO:0009897 external side of plasma membrane IDA
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0016529 sarcoplasmic reticulum ISS
 cellular_componentGO:0030141 secretory granule IDA
 cellular_componentGO:0031012 extracellular matrix IDA
 cellular_componentGO:0031091 platelet alpha granule IDA
 cellular_componentGO:0031093 platelet alpha granule lumen TAS
 cellular_componentGO:0062023 collagen-containing extracellular matrix TAS
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0001786 phosphatidylserine binding IDA
 molecular_functionGO:0001968 fibronectin binding IDA
 molecular_functionGO:0005178 integrin binding IMP
 molecular_functionGO:0005509 calcium ion binding NAS
 molecular_functionGO:0005515 protein binding NAS
 molecular_functionGO:0008201 heparin binding IDA
 molecular_functionGO:0017134 fibroblast growth factor binding IDA
 molecular_functionGO:0030169 low-density lipoprotein particle binding IDA
 molecular_functionGO:0042802 identical protein binding NAS
 molecular_functionGO:0043236 laminin binding IDA
 molecular_functionGO:0043394 proteoglycan binding TAS
 molecular_functionGO:0050431 transforming growth factor beta binding TAS
 molecular_functionGO:0070051 fibrinogen binding IDA
 molecular_functionGO:0070052 collagen V binding IDA


Pathways (from Reactome)
Pathway description
No match


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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