ENSG00000176919


Homo sapiens

Features
Gene ID: ENSG00000176919
  
Biological name :C8G
  
Synonyms : C8G / complement C8 gamma chain / P07360
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 9
Strand: 1
Band: q34.3
Gene start: 136945246
Gene end: 136946974
  
Corresponding Affymetrix probe sets: 210324_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000224181
Ensembl peptide - ENSP00000360697
NCBI entrez gene - 733     See in Manteia.
OMIM - 120930
RefSeq - NM_000606
RefSeq Peptide - NP_000597
swissprot - P07360
swissprot - Q5SQ08
Ensembl - ENSG00000176919
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 c8gENSDARG00000032098Danio rerio
 C8GENSGALG00000040644Gallus gallus
 C8gENSMUSG00000015083Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000566  Lipocalin/cytosolic fatty-acid binding domain
 IPR002345  Lipocalin
 IPR002968  Alpha-1-microglobulin
 IPR012674  Calycin
 IPR022272  Lipocalin family conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006957 complement activation, alternative pathway IEA
 biological_processGO:0006958 complement activation, classical pathway IEA
 biological_processGO:0019835 cytolysis IEA
 biological_processGO:0030449 regulation of complement activation TAS
 biological_processGO:0045087 innate immune response IEA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005579 membrane attack complex IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:0072562 blood microparticle HDA
 molecular_functionGO:0001848 complement binding IEA
 molecular_functionGO:0019841 retinol binding IEA
 molecular_functionGO:0036094 small molecule binding IEA


Pathways (from Reactome)
Pathway description
Terminal pathway of complement
Regulation of Complement cascade


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000113600 C9 / P02748 / complement C9  / complex / reaction
 ENSG00000085063 CD59 / P13987 / CD59 molecule (CD59 blood group)  / reaction / complex
 ENSG00000112936 C7 / P10643 / complement C7  / complex / reaction
 ENSG00000039537 C6 / P13671 / complement C6  / complex / reaction
 ENSG00000157131 C8A / P07357 / complement C8 alpha chain  / complex
 ENSG00000021852 C8B / P07358 / complement C8 beta chain  / complex
 ENSG00000106804 C5 / P01031 / complement C5  / complex / reaction
 ENSG00000109072 VTN / P04004 / vitronectin  / complex / reaction
 ENSG00000120885 CLU / P10909 / clusterin  / complex / reaction






 

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