ENSGALG00000014233


Gallus gallus

Features
Gene ID: ENSGALG00000014233
  
Biological name :FBLN1
  
Synonyms : FBLN1 / fibulin-1 precursor
  
Possible biological names infered from orthology : fibulin 1 / Mus musculus fibulin 1 (Fbln1), transcript variant 2, mRNA. / P23142 / Q08879
  
Species: Gallus gallus
  
Chr. number: 1
Strand: 1
Band:
Gene start: 70545573
Gene end: 70627591
  
Corresponding Affymetrix probe sets: Gga.19964.1.S1_at (Chicken Array)   Gga.2679.1.S1_at (Chicken Array)   Gga.2679.2.S1_a_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000062325
Ensembl peptide - ENSGALP00000022972
NCBI entrez gene - 373979     See in Manteia.
RefSeq - XM_015289893
RefSeq - NM_204165
RefSeq - XM_015289892
RefSeq Peptide - NP_989496
swissprot - F1NX60
swissprot - A0A1L1RU28
Ensembl - ENSGALG00000014233
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 FBLN1ENSDARG00000103311Danio rerio
 FBLN1ENSG00000077942Homo sapiens
 Fbln1ENSMUSG00000006369Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ENSGALG0000003771130
FBN1 / fibrillin 1 / P35555* / Q61554* / Fibrillin-1 Asprosin*ENSGALG0000000496029
FBN2 / fibrillin 2 / P35556* / Q61555* / Fibrillin-2 Fibrillin-2 C-terminal peptide*ENSGALG0000001468629
ENSGALG0000003762529
LTBP1 / latent-transforming growth factor beta-binding protein 1 precursor / Q14766* / Q8CG19* / latent transforming growth factor beta binding protein 1*ENSGALG0000001044824
LTBP2 / latent transforming growth factor beta binding protein 2 / Q14767*ENSGALG0000001025824
FBLN5 / fibulin 5 / Q9UBX5* / Q9WVH9*ENSGALG0000001074723
EFEMP1 / EGF containing fibulin extracellular matrix protein 1 / Q12805* / Q8BPB5* / EGF-containing fibulin-like extracellular matrix protein 1 *ENSGALG0000003790121
ENSGALG000000051209


Protein motifs (from Interpro)
Interpro ID Name
 IPR000020  Anaphylatoxin/fibulin
 IPR000152  EGF-type aspartate/asparagine hydroxylation site
 IPR000742  EGF-like domain
 IPR001881  EGF-like calcium-binding domain
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR013032  EGF-like, conserved site
 IPR017048  Fibulin-1
 IPR018097  EGF-like calcium-binding, conserved site
 IPR026823  Complement Clr-like EGF domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001933 negative regulation of protein phosphorylation IEA
 biological_processGO:0007162 negative regulation of cell adhesion IEA
 biological_processGO:0010952 positive regulation of peptidase activity IEA
 biological_processGO:0030198 extracellular matrix organization IEA
 biological_processGO:0070373 negative regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:0072378 blood coagulation, fibrin clot formation IEA
 biological_processGO:1900025 negative regulation of substrate adhesion-dependent cell spreading IEA
 biological_processGO:2000146 negative regulation of cell motility IEA
 biological_processGO:2000647 negative regulation of stem cell proliferation IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005577 fibrinogen complex IEA
 cellular_componentGO:0005604 basement membrane IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0031012 extracellular matrix IEA
 cellular_componentGO:0071953 elastic fiber IEA
 molecular_functionGO:0001968 fibronectin binding IEA
 molecular_functionGO:0005201 extracellular matrix structural constituent IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0008022 protein C-terminus binding IEA
 molecular_functionGO:0016504 peptidase activator activity IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0044877 protein-containing complex binding IEA
 molecular_functionGO:0070051 fibrinogen binding IEA


Pathways (from Reactome)
Pathway description
Molecules associated with elastic fibres


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000004040 MFAP3 / microfibril-associated glycoprotein 3 precursor / P55082* / microfibril associated protein 3*  / complex / reaction
 ENSGALG00000003578 FN1 / fibronectin 1 / P02751* / P11276* / Fibronectin Anastellin*  / reaction / complex
 ENSGALG00000028295 MFAP1 / microfibril associated protein 1 / Mfap1b* / P55081* / C0HKD9* / Mfap1a* / C0HKD8* / Microfibrillar-associated protein 1A *  / reaction / complex






 

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