ENSMUSG00000019647


Mus musculus

Features
Gene ID: ENSMUSG00000019647
  
Biological name :Sema6a
  
Synonyms : O35464 / Sema6a / Semaphorin-6A
  
Possible biological names infered from orthology : Q9H2E6
  
Species: Mus musculus
  
Chr. number: 18
Strand: -1
Band: C
Gene start: 47235598
Gene end: 47368870
  
Corresponding Affymetrix probe sets: 10458843 (MoGene1.0st)   1421414_a_at (Mouse Genome 430 2.0 Array)   1425903_at (Mouse Genome 430 2.0 Array)   1436458_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000120249
Ensembl peptide - ENSMUSP00000120011
Ensembl peptide - ENSMUSP00000121442
Ensembl peptide - ENSMUSP00000019791
Ensembl peptide - ENSMUSP00000075420
Ensembl peptide - ENSMUSP00000111109
Ensembl peptide - ENSMUSP00000118655
NCBI entrez gene - 20358     See in Manteia.
MGI - MGI:1203727
RefSeq - XM_006525727
RefSeq - NM_001311097
RefSeq - NM_018744
RefSeq - XM_006525726
RefSeq Peptide - NP_061214
RefSeq Peptide - NP_001298026
swissprot - D3YZJ8
swissprot - O35464
swissprot - F6WLW8
swissprot - K3W4S5
swissprot - D3YWM8
Ensembl - ENSMUSG00000019647
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SEMA6AENSGALG00000002294Gallus gallus
 Q9H2E6ENSG00000092421Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q76KF0 / Sema6d / Semaphorin-6D / Q8NFY4*ENSMUSG0000002720047
O54951 / Sema6b / sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B / Q9H3T3* / semaphorin 6B*ENSMUSG0000000122741
Q9WTM3 / Sema6c / sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6C / Q9H3T2* / semaphorin 6C*ENSMUSG0000003877734
Q60519 / Sema5b / Semaphorin-5B / Q9P283*ENSMUSG0000005213324
Sema5a / sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A / Q13591* / semaphorin 5A*ENSMUSG0000002223124
Q9QUR8 / Sema7a / Semaphorin-7A / O75326* / semaphorin 7A (John Milton Hagen blood group)*ENSMUSG0000003826414


Protein motifs (from Interpro)
Interpro ID Name
 IPR001627  Sema domain
 IPR002165  Plexin repeat
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR027231  Semaphorin
 IPR036352  Sema domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001764 neuron migration IMP
 biological_processGO:0006915 apoptotic process NAS
 biological_processGO:0007166 cell surface receptor signaling pathway IDA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0007411 axon guidance NAS
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0051642 centrosome localization IMP
 biological_processGO:0071526 semaphorin-plexin signaling pathway IMP
 biological_processGO:1903671 negative regulation of sprouting angiogenesis ISO
 biological_processGO:2001224 positive regulation of neuron migration IMP
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030424 axon NAS
 molecular_functionGO:0004888 transmembrane signaling receptor activity IMP
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0030215 semaphorin receptor binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000783 abnormal forebrain morphology "malformed or absent anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857]
Show

Allelic Composition: Fgf8tm1.3Mrt/Fgf8tm1.4Mrt,Tg(Tbx1-cre)1Joe/0
Genetic Background: Not Specified

 MP:0000966 reduced sensory neuron number "fewer than normal numbers of cells that innervate an effector (muscle or glandular) tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
Show

Allelic Composition: Adora1tm1Bbf/Adora1tm1Bbf
Genetic Background: B6.129P2-Adora1tm1Bbf

 MP:0002761 abnormal hippocampal mossy fiber morphology "absence or misprojection of axons of neuronal cells in the dentate gyrus" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:4978]
Show

Allelic Composition: Plxna2tm1Hfu/Plxna2tm1Hfu,Plxna4tm1Hfu/Plxna4tm1Hfu
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Plxna2tm1Hfu/Plxna2tm1Hfu,Sema6aGt(KST069)Byg/Sema6aGt(KST069)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Sema6aGt(KST069)Byg/Sema6aGt(KST069)Byg,Sema6btm1Hfu/Sema6btm1Hfu
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6J

 MP:0002762 ectopic granule cells "granule cell body resides in a place other than the external or internal granule layer of the cerebellum" [J:4978]
Show

Allelic Composition: Plxna2tm1Hfu/Plxna2tm1Hfu,Sema6aGt(KST069)Byg/Sema6aGt(KST069)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Plxna2tm1Hfu/Plxna2+,Sema6aGt(KST069)Byg/Sema6a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0002945 abnormal inhibitory postsynaptic currents "defect in the size or duration of currents detected in postsynaptic cells when an inhibitory impulse arrives at the synapse causing hyperpolarization" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Chattm2(cre)Lowl/Chat+,Gt(ROSA)26Sortm9(CAG-tdTomato)Hze/Gt(ROSA)26Sor+,Sema6aGt(KST069)Byg/Sema6aGt(KST069)Byg
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6NCr

 MP:0003463 abnormal single cell response "altered values from controls obtained upon extra- or intracellular recordings from single cells" [Nmice:Neuromice Consortium Submission]
Show

Allelic Composition: Chattm2(cre)Lowl/Chat+,Gt(ROSA)26Sortm9(CAG-tdTomato)Hze/Gt(ROSA)26Sor+,Sema6aGt(KST069)Byg/Sema6aGt(KST069)Byg
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6NCr

 MP:0003734 abnormal inner plexiform layer morphology "malformation/anomalous structure of the retinal cell layer where bipolar and amacrine cell axons synapse with ganglion cell dendrites " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Plxna2tm1Hfu/Plxna2tm1Hfu,Plxna4tm1Hfu/Plxna4tm1Hfu
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Plxna2tm1Hfu/Plxna2tm1Hfu,Sema6aGt(KST069)Byg/Sema6aGt(KST069)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6NCrlj * CBA/JNCrlj

 MP:0005240 abnormal amacrine cell morphology "anomalous structure of the interneurons of the retina" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Plxna2tm1Hfu/Plxna2tm1Hfu,Plxna4tm1Hfu/Plxna4tm1Hfu
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Plxna2tm1Hfu/Plxna2tm1Hfu,Sema6aGt(KST069)Byg/Sema6aGt(KST069)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6NCrlj * CBA/JNCrlj

 MP:0008056 abnormal retinal ganglion cell morphology "any structural anomaly of ganglion neurons located in the innermost nuclear layer of the retina of that receive visual information from photoreceptors via various intermediate cells such as bipolar cells, amacrine cells, and horizontal cells; axons from these cells form the optic nerve and connect mainly to the lateral geniculate nucleus (LGN) and to the suprachiasmatic nucleus in the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Plxna2tm1Hfu/Plxna2tm1Hfu,Plxna4tm1Hfu/Plxna4tm1Hfu
Genetic Background: involves: C57BL/6 * CBA

 MP:0008143 abnormal dendrite morphology "any structural anomaly of the highly branched tree-like process of a neuron that serves as a receptive field and conducts impulses toward the cell body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Plxna2tm1Hfu/Plxna2tm1Hfu,Plxna4tm1Hfu/Plxna4tm1Hfu
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Plxna2tm1Hfu/Plxna2tm1Hfu,Sema6aGt(KST069)Byg/Sema6aGt(KST069)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6NCrlj * CBA/JNCrlj

 MP:0008415 abnormal neurite morphology "any structural anomaly of a neuronal process, either a dendrite or an axon in vivo, or a filamentous projection from a neuron such as is seen in tissue culture" [PMID:12951572]
Show

Allelic Composition: Plxna2tm1Hfu/Plxna2tm1Hfu,Plxna4tm1Hfu/Plxna4tm1Hfu
Genetic Background: involves: C57BL/6 * CBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000026640 P70207 / Plxna2 / Plexin-A2 / O75051*  / reaction / complex
 ENSMUSG00000029765 Plxna4 / Q80UG2 / plexin A4 / Q9HCM2*  / reaction / complex






 

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