ENSMUSG00000022231


Mus musculus

Features
Gene ID: ENSMUSG00000022231
  
Biological name :Sema5a
  
Synonyms : Sema5a / sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
  
Possible biological names infered from orthology : Q13591 / semaphorin 5A
  
Species: Mus musculus
  
Chr. number: 15
Strand: 1
Band: B3.1
Gene start: 32244810
Gene end: 32696341
  
Corresponding Affymetrix probe sets: 10423520 (MoGene1.0st)   1422167_at (Mouse Genome 430 2.0 Array)   1434776_at (Mouse Genome 430 2.0 Array)   1437422_at (Mouse Genome 430 2.0 Array)   1459109_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000069024
NCBI entrez gene - 20356     See in Manteia.
MGI - MGI:107556
RefSeq - XM_011245340
RefSeq - NM_009154
RefSeq - XM_006520043
RefSeq Peptide - NP_033180
swissprot - Q3UPZ0
Ensembl - ENSMUSG00000022231
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sema5aENSDARG00000058821Danio rerio
 SEMA5AENSGALG00000028685Gallus gallus
 Q13591ENSG00000112902Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q60519 / Sema5b / Semaphorin-5B / Q9P283*ENSMUSG0000005213358
O35464 / Sema6a / Semaphorin-6A / Q9H2E6*ENSMUSG0000001964723
O54951 / Sema6b / sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B / Q9H3T3* / semaphorin 6B*ENSMUSG0000000122721
Q9WTM3 / Sema6c / sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6C / Q9H3T2* / semaphorin 6C*ENSMUSG0000003877721
Q76KF0 / Sema6d / Semaphorin-6D / Q8NFY4*ENSMUSG0000002720021
Q9QUR8 / Sema7a / Semaphorin-7A / O75326* / semaphorin 7A (John Milton Hagen blood group)*ENSMUSG0000003826414


Protein motifs (from Interpro)
Interpro ID Name
 IPR000884  Thrombospondin type-1 (TSP1) repeat
 IPR001627  Sema domain
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR016201  PSI domain
 IPR027231  Semaphorin
 IPR036352  Sema domain superfamily
 IPR036383  Thrombospondin type-1 (TSP1) repeat superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
Other semaphorin interactions
O-glycosylation of TSR domain-containing proteins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001614 abnormal vasculature "anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Drd2tm1Mok/Drd2tm1Mok
Genetic Background: involves: 129S/SvEv

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lats2tm1Dgen/Lats2tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003227 abnormal vascular branching morphogenesis "increase, decrease or anomaly in the process by which new vessels sprout off pre-existing vessels" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93157]
Show

Allelic Composition: Drd2tm1Mok/Drd2tm1Mok
Genetic Background: involves: 129S/SvEv

 MP:0003733 abnormal inner nuclear layer morphology "malformation/anomalous structure of the retinal layer which contains the cell bodies of bipolar, horizontal, and amacrine cells" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Etv6tm1.1(RUNX1,hsb5)Lvdw/Etv6+,TgTn(sb-T2/Onc)76Dla/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J * FVB/N

 MP:0003734 abnormal inner plexiform layer morphology "malformation/anomalous structure of the retinal cell layer where bipolar and amacrine cell axons synapse with ganglion cell dendrites " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Etv6tm1.1(RUNX1,hsb5)Lvdw/Etv6+,TgTn(sb-T2/Onc)76Dla/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J * FVB/N

 MP:0004021 abnormal rod electrophysiology "anomaly in the function of dark adapted vision mediated by the rods" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Etv6tm1.1(RUNX1,hsb5)Lvdw/Etv6+,TgTn(sb-T2/Onc)76Dla/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J * FVB/N

 MP:0005240 abnormal amacrine cell morphology "anomalous structure of the interneurons of the retina" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Etv6tm1.1(RUNX1,hsb5)Lvdw/Etv6+,TgTn(sb-T2/Onc)76Dla/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J * FVB/N

 MP:0005253 abnormal eye physiology "anomalous function and/or activity of the ocular system or any of its parts" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Etv6tm1.1(RUNX1,hsb5)Lvdw/Etv6+,TgTn(sb-T2/Onc)76Dla/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J * FVB/N

 MP:0006069 abnormal retinal neuronal layer morphology "malformation in any of the neuronal layers that make up the retina, including the ganglion cell, inner plexiform, inner nuclear, outer plexiform, outer nuclear layers, the inner and outer segments" [smb:Susan M Bello, Mouse Genome Informatics Curator, Gray s Anatomy:ISBN 0-914294-08-3]
Show

Allelic Composition: Etv6tm1.1(RUNX1,hsb5)Lvdw/Etv6+,TgTn(sb-T2/Onc)76Dla/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J * FVB/N

 MP:0006073 abnormal retinal bipolar cell morphology "anomalous structure of the cells that transmit signals from the photoreceptors to retinal amacrine and ganglion cells" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:92623:]
Show

Allelic Composition: Etv6tm1.1(RUNX1,hsb5)Lvdw/Etv6+,TgTn(sb-T2/Onc)76Dla/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J * FVB/N

 MP:0008056 abnormal retinal ganglion cell morphology "any structural anomaly of ganglion neurons located in the innermost nuclear layer of the retina of that receive visual information from photoreceptors via various intermediate cells such as bipolar cells, amacrine cells, and horizontal cells; axons from these cells form the optic nerve and connect mainly to the lateral geniculate nucleus (LGN) and to the suprachiasmatic nucleus in the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Etv6tm1.1(RUNX1,hsb5)Lvdw/Etv6+,TgTn(sb-T2/Onc)76Dla/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J * FVB/N

Allelic Composition: Sema5atm1.2Alk/Sema5atm1.2Alk,Sema5btm1.2Alk/Sema5btm1.2Alk,Tg(Thy1-EGFP)MJrs/0
Genetic Background: involves: 129 * BALB/cJ * C57BL/6 * CBA

 MP:0008143 abnormal dendrite morphology "any structural anomaly of the highly branched tree-like process of a neuron that serves as a receptive field and conducts impulses toward the cell body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Etv6tm1.1(RUNX1,hsb5)Lvdw/Etv6+,TgTn(sb-T2/Onc)76Dla/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J * FVB/N

Allelic Composition: Sema5atm1.2Alk/Sema5atm1.2Alk,Sema5btm1.2Alk/Sema5btm1.2Alk,Tg(Thy1-EGFP)MJrs/0
Genetic Background: involves: 129 * BALB/cJ * C57BL/6 * CBA

 MP:0008415 abnormal neurite morphology "any structural anomaly of a neuronal process, either a dendrite or an axon in vivo, or a filamentous projection from a neuron such as is seen in tissue culture" [PMID:12951572]
Show

Allelic Composition: Sema5atm1.2Alk/Sema5atm1.2Alk,Sema5btm1.2Alk/Sema5btm1.2Alk
Genetic Background: involves: 129 * BALB/cJ * C57BL/6

 MP:0009772 abnormal retinal development "anomaly in any of the steps during embryogenesis that produce the nerve layer lining in the back of the eye which senses light, and creates impulses that travel through the optic nerve to the brain" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sema5atm1.2Alk/Sema5atm1.2Alk,Sema5btm1.2Alk/Sema5btm1.2Alk
Genetic Background: involves: 129 * BALB/cJ * C57BL/6

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Drd2tm1Mok/Drd2tm1Mok
Genetic Background: involves: 129S/SvEv

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000031385 Plxnb3 / Q9QY40 / Plexin-B3 / Q9ULL4*  / reaction / complex






 

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