ENSDARG00000002587


Danio rerio

Features
Gene ID: ENSDARG00000002587
  
Biological name :dpysl3
  
Synonyms : dihydropyrimidinase-like 3 / dpysl3 / Q52PJ5
  
Possible biological names infered from orthology : Dihydropyrimidinase-related protein 3 / Q14195 / Q62188
  
Species: Danio rerio
  
Chr. number: 21
Strand: -1
Band:
Gene start: 42970983
Gene end: 43022048
  
Corresponding Affymetrix probe sets: Dr.16753.2.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000112829
Ensembl peptide - ENSDARP00000065096
NCBI entrez gene - 553166     See in Manteia.
RefSeq - NM_001020512
RefSeq Peptide - NP_001018348
swissprot - E9QDU7
swissprot - Q52PJ5
ZFIN ID - ZDB-GENE-050720-2
Ensembl - ENSDARG00000002587
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 DPYSL3ENSGALG00000007582Gallus gallus
 DPYSL3ENSG00000113657Homo sapiens
 Dpysl3ENSMUSG00000024501Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
DPYSL2 (1 of many) / dihydropyrimidinase like 2 / DPYSL2* / Q16555*ENSDARG0000003897470
dpysl2b / dihydropyrimidinase-like 2b / Q16555* / DPYSL2* / O08553* / dihydropyrimidinase like 2* / Dihydropyrimidinase-related protein 2 *ENSDARG0000003208366
crmp1 / collapsin response mediator protein 1 / Q14194*ENSDARG0000005674266
dpysl4 / dihydropyrimidinase-like 4 / O14531*ENSDARG0000010349065
dpys / dihydropyrimidinase / Q14117* / Q9EQF5*ENSDARG0000007954353
dpysl5b / dihydropyrimidinase-like 5bENSDARG0000005931148
dpysl5a / dihydropyrimidinase-like 5aENSDARG0000001114147
zgc:103559ENSDARG0000003829318


Protein motifs (from Interpro)
Interpro ID Name
 IPR006680  Amidohydrolase-related
 IPR011059  Metal-dependent hydrolase, composite domain superfamily
 IPR011778  Hydantoinase/dihydropyrimidinase
 IPR030628  Dihydropyrimidinase-related protein 3
 IPR032466  Metal-dependent hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0010975 regulation of neuron projection development IEA
 biological_processGO:0030334 regulation of cell migration IEA
 biological_processGO:0048678 response to axon injury IEA
 biological_processGO:0048936 peripheral nervous system neuron axonogenesis IMP
 biological_processGO:0051017 actin filament bundle assembly IEA
 biological_processGO:0051491 positive regulation of filopodium assembly IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0030426 growth cone IEA
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds IEA


Pathways (from Reactome)
Pathway description
CRMPs in Sema3A signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0009150 Rohon-Beard neuron Rohon-Beard neuron displaced to spinal cord axis, abnormal
Rohon-Beard neuron axon decreased amount , abnormal
Show

 ZFA:0009165 neural crest cell neural crest cell displaced to spinal cord lateral margin, abnormal
Show

 ZFA:0009243 CaP motoneuron CaP motoneuron mislocalised , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000017803 gsk3b / glycogen synthase kinase 3 beta / P49841* / Q9WV60*  / reaction
 ENSDARG00000019328 plxna4 / plexin A4 / Q80UG2* / Q9HCM2*  / reaction / complex
 ENSDARG00000007172 plxna3 / plexin A3 / P51805* / P70208*  / reaction / complex
 ENSDARG00000025319 fynb / F1RDG9 / FYN proto-oncogene, Src family tyrosine kinase b / FYN* / P39688* / P06241* / Tyrosine-protein kinase Fyn * / FYN proto-oncogene, Src family tyrosine kinase*  / reaction / complex
 ENSDARG00000011370 fyna / Q6EWH2 / FYN proto-oncogene, Src family tyrosine kinase a / FYN* / P06241* / P39688* / Tyrosine-protein kinase Fyn * / FYN proto-oncogene, Src family tyrosine kinase*  / complex / reaction
 ENSDARG00000103490 dpysl4 / dihydropyrimidinase-like 4 / O14531*  / complex
 ENSDARG00000102153 nrp1a / neuropilin 1a / NRP1* / O14786* / P97333* / neuropilin 1*  / complex / reaction
 ENSDARG00000011449 fes / FES proto-oncogene, tyrosine kinase / P07332* / P16879* / Tyrosine-protein kinase Fes/Fps *  / reaction / complex
 ENSDARG00000056683 cdk5 / cyclin-dependent kinase 5 / P49615* / Q00535* / Cyclin-dependent-like kinase 5 *  / complex / reaction
 ENSDARG00000045087 cdk5r1b / cyclin-dependent kinase 5, regulatory subunit 1b (p35) / Q15078* / P61809* / CDK5R1* / cyclin dependent kinase 5 regulatory subunit 1* / Cyclin-dependent kinase 5 activator 1 Cycl...  / complex / reaction
 ENSDARG00000037916 cdk5r1a / cyclin-dependent kinase 5, regulatory subunit 1a (p35) / Q15078* / P61809* / CDK5R1* / cyclin dependent kinase 5 regulatory subunit 1* / Cyclin-dependent kinase 5 activator 1 Cycl...  / complex / reaction
 ENSDARG00000002587 dpysl3 / Q52PJ5 / dihydropyrimidinase-like 3 / Q14195*  / complex
 ENSDARG00000052468 si:dkeyp-80c12.7 / GSK3B (1 of many) / GSK3B* / P49841* / Q9WV60* / glycogen synthase kinase 3 beta*  / reaction






 

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