ENSMUSG00000024501


Mus musculus

Features
Gene ID: ENSMUSG00000024501
  
Biological name :Dpysl3
  
Synonyms : Dihydropyrimidinase-related protein 3 / Dpysl3 / Q62188
  
Possible biological names infered from orthology : dihydropyrimidinase like 3 / Q14195
  
Species: Mus musculus
  
Chr. number: 18
Strand: -1
Band: B3
Gene start: 43320979
Gene end: 43438286
  
Corresponding Affymetrix probe sets: 10458663 (MoGene1.0st)   1415877_at (Mouse Genome 430 2.0 Array)   1438789_s_at (Mouse Genome 430 2.0 Array)   1454613_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000113604
Ensembl peptide - ENSMUSP00000114981
Ensembl peptide - ENSMUSP00000113711
Ensembl peptide - ENSMUSP00000025379
Ensembl peptide - ENSMUSP00000112928
NCBI entrez gene - 22240     See in Manteia.
MGI - MGI:1349762
RefSeq - NM_001136086
RefSeq - NM_001291455
RefSeq - NM_009468
RefSeq Peptide - NP_001129558
RefSeq Peptide - NP_001278384
RefSeq Peptide - NP_033494
swissprot - Q62188
swissprot - D3Z567
swissprot - D3YUS0
swissprot - Q3TT92
swissprot - E9PWE8
Ensembl - ENSMUSG00000024501
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dpysl3ENSDARG00000002587Danio rerio
 DPYSL3ENSGALG00000007582Gallus gallus
 DPYSL3ENSG00000113657Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Crmp1 / P97427 / Dihydropyrimidinase-related protein 1 / Q14194* / collapsin response mediator protein 1*ENSMUSG0000002912169
Dpysl2 / O08553 / Dihydropyrimidinase-related protein 2 / Q16555* / dihydropyrimidinase like 2*ENSMUSG0000002204862
Dpysl4 / dihydropyrimidinase like 4 / O14531*ENSMUSG0000002547858
Dpys / Q9EQF5 / Dihydropyrimidinase / Q14117*ENSMUSG0000002230444
Dpysl5 / Q9EQF6 / Mus musculus dihydropyrimidinase-like 5 (Dpysl5), transcript variant 2, mRNA. / Q9BPU6* / dihydropyrimidinase like 5*ENSMUSG0000002916842


Protein motifs (from Interpro)
Interpro ID Name
 IPR006680  Amidohydrolase-related
 IPR011059  Metal-dependent hydrolase, composite domain superfamily
 IPR011778  Hydantoinase/dihydropyrimidinase
 IPR030628  Dihydropyrimidinase-related protein 3
 IPR032466  Metal-dependent hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007399 nervous system development IDA
 biological_processGO:0010975 regulation of neuron projection development IEA
 biological_processGO:0010976 positive regulation of neuron projection development ISS
 biological_processGO:0010977 negative regulation of neuron projection development ISS
 biological_processGO:0030334 regulation of cell migration IEA
 biological_processGO:0030336 negative regulation of cell migration ISS
 biological_processGO:0048666 neuron development IEA
 biological_processGO:0048678 response to axon injury IEA
 biological_processGO:0051017 actin filament bundle assembly IEA
 biological_processGO:0051260 protein homooligomerization ISS
 biological_processGO:0051491 positive regulation of filopodium assembly IEA
 biological_processGO:0051764 actin crosslink formation ISS
 biological_processGO:0071345 cellular response to cytokine stimulus ISS
 cellular_componentGO:0005615 extracellular space ISS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol ISS
 cellular_componentGO:0030027 lamellipodium ISS
 cellular_componentGO:0030426 growth cone ISS
 cellular_componentGO:0031941 filamentous actin ISS
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0044297 cell body ISS
 cellular_componentGO:0070382 exocytic vesicle ISS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds IEA
 molecular_functionGO:0017124 SH3 domain binding ISS
 molecular_functionGO:0031005 filamin binding ISO
 molecular_functionGO:0035374 chondroitin sulfate binding ISS
 molecular_functionGO:0051219 phosphoprotein binding IPI


Pathways (from Reactome)
Pathway description
CRMPs in Sema3A signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0003651 abnormal axon outgrowth "defect/abnormality in the ability of an axon to extend from a neuron cell body" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:96121]
Show

Allelic Composition: Arhgap28tm2b(KOMP)Wtsi/Arhgap28tm2b(KOMP)Wtsi
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0004768 abnormal axonal transport "any functional anomaly of the directed movement of organelles or vesicles along microtubules in nerve cell axons" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Arhgap28tm2b(KOMP)Wtsi/Arhgap28tm2b(KOMP)Wtsi
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0008143 abnormal dendrite morphology "any structural anomaly of the highly branched tree-like process of a neuron that serves as a receptive field and conducts impulses toward the cell body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rgs18m1H/Rgs18m1H
Genetic Background: BALB/cAnN-Rgs18m1H/H

 MP:0009937 abnormal neuron differentiation "abnormal growth or development of the cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Arhgap28tm2b(KOMP)Wtsi/Arhgap28tm2b(KOMP)Wtsi
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0009940 abnormal hippocampus pyramidal cell morphology "any structural anomaly of the projection neuron in the pyramidal layer of the hippocampus" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rgs18m1H/Rgs18m1H
Genetic Background: BALB/cAnN-Rgs18m1H/H

 MP:0009970 increased hippocampus pyramidal cell number "increased number of the projection neurons in the pyramidal layer of the hippocampus" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rgs18m1H/Rgs18m1H
Genetic Background: BALB/cAnN-Rgs18m1H/H

Allelic Composition: Dpysl3tm1Gosh/Dpysl3+,Tg(Thy1-EGFP)MJrs/0
Genetic Background: involves: C57BL/6J * C57BL/6NCrlj * CBA * CBA/JNCrlj

 MP:0012458 decreased hippocampus pyramidal cell length "reduced length of a multipolar projection neuron in the hippocampus pyramidal cell layer" [MGI:csmith]
Show

Allelic Composition: Rgs18m1H/Rgs18m1H
Genetic Background: BALB/cAnN-Rgs18m1H/H

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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