ENSMUSG00000029121


Mus musculus

Features
Gene ID: ENSMUSG00000029121
  
Biological name :Crmp1
  
Synonyms : Crmp1 / Dihydropyrimidinase-related protein 1 / P97427
  
Possible biological names infered from orthology : collapsin response mediator protein 1 / Q14194
  
Species: Mus musculus
  
Chr. number: 5
Strand: 1
Band: B3
Gene start: 37241940
Gene end: 37292133
  
Corresponding Affymetrix probe sets: 10521498 (MoGene1.0st)   1448289_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000143895
Ensembl peptide - ENSMUSP00000144408
Ensembl peptide - ENSMUSP00000031004
Ensembl peptide - ENSMUSP00000109795
Ensembl peptide - ENSMUSP00000143847
NCBI entrez gene - 12933     See in Manteia.
MGI - MGI:107793
RefSeq - NM_001136058
RefSeq - NM_007765
RefSeq Peptide - NP_031791
RefSeq Peptide - NP_001129530
swissprot - A0A0J9YUZ1
swissprot - Q71H75
swissprot - A0A0J9YTX5
swissprot - P97427
swissprot - Q6P1J1
Ensembl - ENSMUSG00000029121
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 crmp1ENSDARG00000056742Danio rerio
 CRMP1ENSGALG00000041203Gallus gallus
 CRMP1ENSG00000072832Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Dpysl3 / Q62188 / Dihydropyrimidinase-related protein 3 / Q14195* / dihydropyrimidinase like 3*ENSMUSG0000002450168
Dpysl2 / O08553 / Dihydropyrimidinase-related protein 2 / Q16555* / dihydropyrimidinase like 2*ENSMUSG0000002204862
Dpysl4 / dihydropyrimidinase like 4 / O14531*ENSMUSG0000002547857
Dpys / Q9EQF5 / Dihydropyrimidinase / Q14117*ENSMUSG0000002230443
Dpysl5 / Q9EQF6 / Mus musculus dihydropyrimidinase-like 5 (Dpysl5), transcript variant 2, mRNA. / Q9BPU6* / dihydropyrimidinase like 5*ENSMUSG0000002916841


Protein motifs (from Interpro)
Interpro ID Name
 IPR006680  Amidohydrolase-related
 IPR011059  Metal-dependent hydrolase, composite domain superfamily
 IPR011778  Hydantoinase/dihydropyrimidinase
 IPR030612  Dihydropyrimidinase-related protein 4
 IPR030624  Dihydropyrimidinase-related protein 1
 IPR032466  Metal-dependent hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000226 microtubule cytoskeleton organization IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0007411 axon guidance IEA
 biological_processGO:0010977 negative regulation of neuron projection development ISO
 biological_processGO:0048666 neuron development IEA
 biological_processGO:0070997 neuron death IEA
 biological_processGO:0071526 semaphorin-plexin signaling pathway IGI
 biological_processGO:0097485 neuron projection guidance IEA
 biological_processGO:1904530 negative regulation of actin filament binding ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005813 centrosome ISO
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005819 spindle IEA
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0030425 dendrite IDA
 cellular_componentGO:0030426 growth cone IDA
 cellular_componentGO:0030496 midbody ISO
 cellular_componentGO:0031941 filamentous actin IDA
 cellular_componentGO:0043025 neuronal cell body IDA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds IEA
 molecular_functionGO:0031005 filamin binding ISO
 molecular_functionGO:0051219 phosphoprotein binding IPI


Pathways (from Reactome)
Pathway description
CRMPs in Sema3A signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000813 abnormal hippocampal laminar structure "malformed or missing layers of the laminar structure of the hippocampus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:38857]
Show

Allelic Composition: Gad1tm1Tama/?,Lhx6tm2Vpa/Lhx6tm2Vpa
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * CBA

 MP:0001463 abnormal spatial learning "defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University]
Show

Allelic Composition: Runx1tm8Spe/Runx1tm8Spe
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0002207 abnormal long term potentiation "alterations in a persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Runx1tm8Spe/Runx1tm8Spe
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Crmp1tm1.1Swl/Crmp1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004948 abnormal neuronal precursor proliferation "any anomaly in the ability of a neuroblast population to undergo rapid expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gad1tm1Tama/?,Lhx6tm2Vpa/Lhx6tm2Vpa
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * CBA

 MP:0006009 abnormal neuronal migration "defective or impaired movement of immature neurons from germinal zones to specific positions where they will reside as they mature" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Gad1tm1Tama/?,Lhx6tm2Vpa/Lhx6tm2Vpa
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * CBA

 MP:0008143 abnormal dendrite morphology "any structural anomaly of the highly branched tree-like process of a neuron that serves as a receptive field and conducts impulses toward the cell body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4tm1Jfm,Bmp7tm1Jfm/Bmp7+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

Allelic Composition: Crmp1tm1Pako/Crmp1tm1Pako,Dpysl2tm1.1Gosh/Dpysl2tm1.1Gosh,Tg(Thy1-YFP)HJrs/0
Genetic Background: involves: 129 * C57BL/6J * CBA * FVB/N

 MP:0009940 abnormal hippocampus pyramidal cell morphology "any structural anomaly of the projection neuron in the pyramidal layer of the hippocampus" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Runx1tm8Spe/Runx1tm8Spe
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0009969 abnormal cerebral cortex pyramidal cell morphology "any structural anomaly of the projection neurons in the pyramidal cell layer of the cerebral cortex" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Crmp1tm1Pako/Crmp1tm1Pako,Dpysl2tm1.1Gosh/Dpysl2tm1.1Gosh,Tg(Thy1-YFP)HJrs/0
Genetic Background: involves: 129 * C57BL/6J * CBA * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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