ENSMUSG00000022048


Mus musculus

Features
Gene ID: ENSMUSG00000022048
  
Biological name :Dpysl2
  
Synonyms : Dihydropyrimidinase-related protein 2 / Dpysl2 / O08553
  
Possible biological names infered from orthology : dihydropyrimidinase like 2 / Q16555
  
Species: Mus musculus
  
Chr. number: 14
Strand: -1
Band: D1
Gene start: 66802864
Gene end: 66868688
  
Corresponding Affymetrix probe sets: 10420988 (MoGene1.0st)   1433770_at (Mouse Genome 430 2.0 Array)   1450502_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000022629
NCBI entrez gene - 12934     See in Manteia.
MGI - MGI:1349763
RefSeq - NM_009955
RefSeq - XM_006518508
RefSeq Peptide - NP_034085
swissprot - O08553
Ensembl - ENSMUSG00000022048
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 DPYSL2 (1 of many)ENSDARG00000038974Danio rerio
 dpysl2bENSDARG00000032083Danio rerio
 DPYSL2ENSGALG00000000227Gallus gallus
 DPYSL2ENSG00000092964Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Crmp1 / P97427 / Dihydropyrimidinase-related protein 1 / Q14194* / collapsin response mediator protein 1*ENSMUSG0000002912175
Dpysl4 / dihydropyrimidinase like 4 / O14531*ENSMUSG0000002547874
Dpysl3 / Q62188 / Dihydropyrimidinase-related protein 3 / Q14195* / dihydropyrimidinase like 3*ENSMUSG0000002450174
Dpys / Q9EQF5 / Dihydropyrimidinase / Q14117*ENSMUSG0000002230452
Dpysl5 / Q9EQF6 / Mus musculus dihydropyrimidinase-like 5 (Dpysl5), transcript variant 2, mRNA. / Q9BPU6* / dihydropyrimidinase like 5*ENSMUSG0000002916850


Protein motifs (from Interpro)
Interpro ID Name
 IPR006680  Amidohydrolase-related
 IPR011059  Metal-dependent hydrolase, composite domain superfamily
 IPR011778  Hydantoinase/dihydropyrimidinase
 IPR030615  Dihydropyrimidinase-related protein 2
 IPR032466  Metal-dependent hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001975 response to amphetamine IEA
 biological_processGO:0006897 endocytosis ISO
 biological_processGO:0007010 cytoskeleton organization IDA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0007411 axon guidance IEA
 biological_processGO:0007420 brain development IEA
 biological_processGO:0010975 regulation of neuron projection development IGI
 biological_processGO:0014049 positive regulation of glutamate secretion IEA
 biological_processGO:0021510 spinal cord development IEA
 biological_processGO:0021772 olfactory bulb development IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030516 regulation of axon extension IEA
 biological_processGO:0042220 response to cocaine IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0045664 regulation of neuron differentiation IEA
 biological_processGO:0048489 synaptic vesicle transport IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005829 cytosol ISS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005874 microtubule ISO
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane ISO
 cellular_componentGO:0030424 axon IDA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0030426 growth cone IEA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0043195 terminal bouton IEA
 cellular_componentGO:0043209 myelin sheath IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008017 microtubule binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds IEA
 molecular_functionGO:0019901 protein kinase binding IPI
 molecular_functionGO:0042802 identical protein binding ISO


Pathways (from Reactome)
Pathway description
CRMPs in Sema3A signaling
Recycling pathway of L1


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0008143 abnormal dendrite morphology "any structural anomaly of the highly branched tree-like process of a neuron that serves as a receptive field and conducts impulses toward the cell body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4tm1Jfm,Bmp7tm1Jfm/Bmp7+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

Allelic Composition: Crmp1tm1Pako/Crmp1tm1Pako,Dpysl2tm1.1Gosh/Dpysl2tm1.1Gosh
Genetic Background: involves: 129 * C57BL/6J * FVB/N

Allelic Composition: Crmp1tm1Pako/Crmp1tm1Pako,Dpysl2tm1.1Gosh/Dpysl2tm1.1Gosh,Tg(Thy1-YFP)HJrs/0
Genetic Background: involves: 129 * C57BL/6J * CBA * FVB/N

Allelic Composition: Dpysl2tm1.1Gosh/Dpysl2tm1.1Gosh,Tg(Thy1-YFP)HJrs/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CBA * FVB/N

 MP:0009969 abnormal cerebral cortex pyramidal cell morphology "any structural anomaly of the projection neurons in the pyramidal cell layer of the cerebral cortex" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Crmp1tm1Pako/Crmp1tm1Pako,Dpysl2tm1.1Gosh/Dpysl2tm1.1Gosh,Tg(Thy1-YFP)HJrs/0
Genetic Background: involves: 129 * C57BL/6J * CBA * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000002957 Ap2a2 / P17427 / Mus musculus adaptor-related protein complex 2, alpha 2 subunit (Ap2a2), transcript variant 1, mRNA. / O94973* / adaptor related protein complex 2 alpha 2 subunit*  / complex
 ENSMUSG00000021224 Numb / Q9QZS3 / NUMB, endocytic adaptor protein / P49757*  / complex
 ENSMUSG00000060279 Ap2a1 / P17426 / AP-2 complex subunit alpha-1 / O95782* / adaptor related protein complex 2 alpha 1 subunit*  / complex






 

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