ENSG00000092964


Homo sapiens

Features
Gene ID: ENSG00000092964
  
Biological name :DPYSL2
  
Synonyms : dihydropyrimidinase like 2 / DPYSL2 / Q16555
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 8
Strand: 1
Band: p21.2
Gene start: 26514022
Gene end: 26658178
  
Corresponding Affymetrix probe sets: 200762_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000309539
Ensembl peptide - ENSP00000431117
Ensembl peptide - ENSP00000427985
Ensembl peptide - ENSP00000427954
NCBI entrez gene - 1808     See in Manteia.
OMIM - 602463
RefSeq - NM_001197293
RefSeq - NM_001244604
RefSeq - NM_001386
RefSeq Peptide - NP_001184222
RefSeq Peptide - NP_001377
RefSeq Peptide - NP_001231533
swissprot - Q16555
swissprot - A0A1C7CYX9
swissprot - E5RFU4
Ensembl - ENSG00000092964
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 DPYSL2 (1 of many)ENSDARG00000038974Danio rerio
 dpysl2bENSDARG00000032083Danio rerio
 DPYSL2ENSGALG00000000227Gallus gallus
 Dpysl2ENSMUSG00000022048Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
DPYSL3 / Q14195 / dihydropyrimidinase like 3ENSG0000011365768
CRMP1 / Q14194 / collapsin response mediator protein 1ENSG0000007283267
DPYSL4 / O14531 / dihydropyrimidinase like 4ENSG0000015164063
DPYS / Q14117 / dihydropyrimidinaseENSG0000014764746
DPYSL5 / Q9BPU6 / dihydropyrimidinase like 5ENSG0000015785143


Protein motifs (from Interpro)
Interpro ID Name
 IPR006680  Amidohydrolase-related
 IPR011059  Metal-dependent hydrolase, composite domain superfamily
 IPR011778  Hydantoinase/dihydropyrimidinase
 IPR030615  Dihydropyrimidinase-related protein 2
 IPR032466  Metal-dependent hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001975 response to amphetamine IEA
 biological_processGO:0006139 nucleobase-containing compound metabolic process TAS
 biological_processGO:0006897 endocytosis IMP
 biological_processGO:0007010 cytoskeleton organization ISS
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development TAS
 biological_processGO:0007411 axon guidance IEA
 biological_processGO:0007420 brain development IEA
 biological_processGO:0010975 regulation of neuron projection development IEA
 biological_processGO:0014049 positive regulation of glutamate secretion IEA
 biological_processGO:0021510 spinal cord development IEA
 biological_processGO:0021772 olfactory bulb development IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030516 regulation of axon extension IEA
 biological_processGO:0042220 response to cocaine IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0045664 regulation of neuron differentiation IEA
 biological_processGO:0048489 synaptic vesicle transport IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005874 microtubule IDA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0030426 growth cone IEA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0043195 terminal bouton IEA
 cellular_componentGO:0043209 myelin sheath IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0004157 dihydropyrimidinase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008017 microtubule binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0042802 identical protein binding IPI


Pathways (from Reactome)
Pathway description
CRMPs in Sema3A signaling
Recycling pathway of L1


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000198910 L1CAM / P32004 / L1 cell adhesion molecule  / complex / reaction
 ENSG00000183020 AP2A2 / O94973 / adaptor related protein complex 2 alpha 2 subunit  / complex
 ENSG00000196961 AP2A1 / O95782 / adaptor related protein complex 2 alpha 1 subunit  / complex
 ENSG00000133961 NUMB / P49757 / NUMB, endocytic adaptor protein  / complex






 

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