ENSMUSG00000029168


Mus musculus

Features
Gene ID: ENSMUSG00000029168
  
Biological name :Dpysl5
  
Synonyms : Dpysl5 / Mus musculus dihydropyrimidinase-like 5 (Dpysl5), transcript variant 2, mRNA. / Q9EQF6
  
Possible biological names infered from orthology : dihydropyrimidinase like 5 / Q9BPU6
  
Species: Mus musculus
  
Chr. number: 5
Strand: 1
Band: B1
Gene start: 30711564
Gene end: 30799375
  
Corresponding Affymetrix probe sets: 10520527 (MoGene1.0st)   1441246_s_at (Mouse Genome 430 2.0 Array)   1449290_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000085400
Ensembl peptide - ENSMUSP00000098985
Ensembl peptide - ENSMUSP00000110377
NCBI entrez gene - 65254     See in Manteia.
MGI - MGI:1929772
RefSeq - XM_006504045
RefSeq - NM_001356948
RefSeq - NM_023047
RefSeq Peptide - NP_075534
RefSeq Peptide - NP_001343877
swissprot - Q3SYJ1
swissprot - Q9EQF6
Ensembl - ENSMUSG00000029168
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENSGALG00000041028Gallus gallus
 DPYSL5ENSG00000157851Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Dpys / Q9EQF5 / Dihydropyrimidinase / Q14117*ENSMUSG0000002230452
Dpysl3 / Q62188 / Dihydropyrimidinase-related protein 3 / Q14195* / dihydropyrimidinase like 3*ENSMUSG0000002450151
Dpysl2 / O08553 / Dihydropyrimidinase-related protein 2 / Q16555* / dihydropyrimidinase like 2*ENSMUSG0000002204851
Dpysl4 / dihydropyrimidinase like 4 / O14531*ENSMUSG0000002547850
Crmp1 / P97427 / Dihydropyrimidinase-related protein 1 / Q14194* / collapsin response mediator protein 1*ENSMUSG0000002912150


Protein motifs (from Interpro)
Interpro ID Name
 IPR006680  Amidohydrolase-related
 IPR011059  Metal-dependent hydrolase, composite domain superfamily
 IPR011778  Hydantoinase/dihydropyrimidinase
 IPR030626  Dihydropyrimidinase-related protein 5
 IPR032466  Metal-dependent hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0007411 axon guidance IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0030425 dendrite IDA
 cellular_componentGO:0043025 neuronal cell body IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008017 microtubule binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds IEA


Pathways (from Reactome)
Pathway description
CRMPs in Sema3A signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000877 abnormal Purkinje cell "any structural anomaly of the neurons located at the interface of the molecular and internal granule layers of the cerebellar cortex; these inhibitory neurons provide the output of the cerebellar cortex through axons that project into the white matter, and extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells" [J:46140, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Abi1tm1Pen/Abi1tm1Pen
Genetic Background: involves: C57BL/6

 MP:0001513 limb grasping "mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Abi1tm1Pen/Abi1tm1Pen
Genetic Background: involves: C57BL/6

 MP:0001899 absent long term depression "lack of the normal, persistent activity-dependent decrease in synaptic efficacy between neurons, often following slow, weak stimulation of CA1 neurons" [Principles of Neural Science:ISBN 0-8385-8034-3, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Abi1tm1Pen/Abi1tm1Pen
Genetic Background: involves: C57BL/6

 MP:0004811 abnormal neuron physiology "anomalous function of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:National Library of Medicine_Medical Subject Headings]
Show

Allelic Composition: Abi1tm1Pen/Abi1tm1Pen
Genetic Background: involves: C57BL/6

 MP:0008572 abnormal Purkinje cell dendrite morphology "any strucutral anomaly of the Purkinje cell body projections with hundreds of parallel spiny branches reaching up into the molecular layer" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Abi1tm1Pen/Abi1tm1Pen
Genetic Background: involves: C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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